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| 1 | Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions显示文摘Peripheral nerve regeneration remains a significant clinical challenge due to the unsatisfactory functional recovery and public health burden.Exosomes,especially those derived from mesenchymal stem cells(MSCs),are promising as potential cell-free therapeutics and gene therapy vehicles for promoting neural regeneration.In this study,we reported the differentiation of human adipose derived MSCs(hADMSCs)towards the Schwann cell(SC)phenotype(hADMSC-SCs)and then isolated exosomes from hADMSCs with and without differentiation(i.e.,dExo vs uExo).We assessed and compared the effects of uExo and dExo on antioxidative,angiogenic,anti-inflammatory,and axon growth promoting properties by using various peripheral nerve-related cells.Our results demonstrated that hADMSC-SCs secreted more neurotrophic factors and other growth factors,compared to hADMSCs without differentiation.The dExo isolated from hADMSC-SCs protected rat SCs from oxidative stress and enhanced HUVEC migration and angiogenesis.Compared to uExo,dExo also had improved performances in downregulating pro-inflammatory gene expressions and cytokine secretions and promoting axonal growth of sensory neurons differentiated from human induced pluripotent stem cells.Furthermore,microRNA(miRNA)sequencing analysis revealed that exosomes and their parent cells shared some similarities in their miRNA profiles and exosomes displayed a distinct miRNA signature.Many more miRNAs were identified in dExo than in uExo.Several upregulated miRNAs,like miRNA-132-3p and miRNA-199b-5p,were highly related to neuroprotection,anti-inflammation,and angiogenesis.The dExo can effectively modulate various peripheral nerve-related cellular functions and is promising for cell-free biological therapeutics to enhance neural regeneration. | Bo Liu Yunfan Kong Wen Shi Mitchell Kuss Ke Liao Guoku Hu Peng Xiao Jagadesan Sankarasubramanian Chittibabu Guda Xinglong Wang Yuguo Lei Bin Duan | 2022 | Bioactive Materials2022，7，8： | 3 |
| 2 | Electrochemical,spectroelectrochemical and spectroscopic evidences for copolymer formation between diphenylamine and m-toluidine显示文摘 | Santhosh P Sankarasubramanian M Thanneermalai M | 2004 | Materials Chemistry and Physics2004，85，： | 1 |
| 3 | A capacity fade model for lithium-ion batteries including diffusion and kinetics 显示文摘 | SANKARASUBRAMANIAN S KRISHNAMURTHY B | 2012 | Electrochimica Acta2012，70，： | 1 |
| 4 | A survey of sensor networks显示文摘 | Akyldiz F Su W Sankarasubramanian Y | 2002 | IEEE Communications Magazine2002，40，8： | 1 |
| 5 | Climate elasticity of streamflow in the United States 显示文摘 | SANKARASUBRAMANIAN A VOGEL R M LIMBRUNNER J F | 2001 | Water Resources Research2001，37，6： | 1 |
| 6 | Wheless sensor networks:A survey显示文摘 | Akyildiz I F Sankarasubramanian Y | 2002 | Computer Networks Journal2002，38，4： | 1 |
| 7 | Wireless sensor networks: A survey 显示文摘 | IAKYILDIZ I F SU W SANKARASUBRAMANIAN Y | 2002 | Computer Networks2002，38，4： | 1 |
| 8 | A Survey on Sensor Networks显示文摘 | AKYILDIZ I F SU W L SANKARASUBRAMANIAN Y | 2007 | In IEEE Communication Magazine2007，40，8： | 1 |
| 9 | Thermal fracture of zirconia - mullite composite thermal barrier coatings under thermal shock: An experimental study 显示文摘 | Gilbert Anna Kokini Klod Sankarasubramanian Santosh | 2008 | Surface & Coatings Technology2008，202，： | 1 |
| 10 | Electrochem- ical, spectroelectrochemical and spectroscopic evidences for copolymer formation between diphenylamine and m-toluidine 显示文摘 | SANTHOSH P SANKARASUBRAMANIAN M THANNEERMALAI M GOPALAN A VASUDEVAN T | 2004 | Mater Chem Phys2004，85，23： | 1 |
| 11 | Thermal fracture of zirconia–mullite composite thermal barrier coatings under thermal shock: A numerical study显示文摘 | Anna Gilbert Klod Kokini Santosh Sankarasubramanian | 2008 | Surface & Coatings Technology2008，，1： | 1 |
| 12 | Wireless sensor networks:a survey显示文摘 | Akyildiz F Su W Sankarasubramanian Y | 2002 | Computer Networks2002，38，4： | 1 |
| 13 | A survey on sensor networks显示文摘 | Akyildiz F Su W Sankarasubramanian Y | 2002 | IEEE Communications Magazine2002，40，8： | 1 |
| 14 | A survey of sensor networks 显示文摘 | AKULDIZ F SU W SANKARASUBRAMANIAN Y | 2002 | IEEE Communications Magazine2002，40，8： | 1 |
| 15 | Wireless sensor networks:A survey显示文摘 | AKYLDIZ IF SU W SANKARASUBRAMANIAN Y | | 0，，04： | 1 |
| 16 | Integration and calibration of a multi slit spectropolarimeter显示文摘 | R. Devaraj K. Sankarasubramanian Surekha Kamath | 2013 | Advances in Space Research2013，，1： | 1 |
| 17 | A survey on sensor networks显示文摘 | Akyildiz I F Su W L Sankarasubramanian Y A | | 0，，08： | 1 |
| 18 | Optimal Order Quantity for Pre-determined Level of Profit显示文摘 | Sankarasubramanian E Kumaraswamy S | 1983 | Management Science1983，29，4： | 1 |
| 19 | Thermal fracture of zirconia-mullite composite thermal barri- er coatings under thermal shock : An experimental study 显示文摘 | Anna Gilbert Klod Kokini Santosh Sankarasubramanian | 2008 | Surface and Coatings Technology2008，202，10： | 1 |
| 20 | Wireless sensor networks:A survey显示文摘 | AKYILDIZ I F SU W SANKARASUBRAMANIAN Y | 2002 | Computer Networks2002，38，4： | 1 |
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