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| 1 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 2 | Multiple sclerosing hemangiomas of the lung显示文摘 | Soumil VJ Navin B Sangeeta D Na J | 2004 | Asian Cardiovasc Thorac Ann2004，12，4： | 1 |
| 3 | Multiple sclemsing hemangi- omas d the lung显示文摘 | SoumilVI Navin B Sangeeta D et 81 | 2004 | Asian Cardiovase Thorac Ann2004，12，4： | 1 |
| 4 | Probing the Cytotoxicity of Semiconductor Quantum Dots 显示文摘 | Austin M D Warren C W C Sangeeta N B | 2004 | Nano Letters2004，4，1： | 1 |
| 5 | Role of Cbfal in Ameloblastin gene transcription显示文摘 | Sangeeta D Paul HK | 2001 | J Biol Chem2001，276，35： | 1 |
| 6 | Neutron flux measurements with a Li2B407 crystal 显示文摘 | SANGEETA CHENNAKESAVULU K DESAI D G | 2007 | Nucl Instrum Meth A2007，571，： | 1 |
| 7 | Multiple sclerosing hemangiomas of the lung显示文摘 | Soumil VJ Navin B Sangeeta D | 2004 | Asian Cardiovasc Thorac Ann2004，12，： | 1 |
| 8 | Isoflavonoid biosynthesis and accumulation in developing soybean seeds 显示文摘 | SANGEETA D BRIAN D M RUTHANNE W | 2003 | Plant Molecular Biology2003，53，6： | 1 |
| 9 | Effect of Non-stichiometry on Some Properties of Lead Tungstate Single Crystals显示文摘 | Sabharwal S C Sangeeta Desai D G | 1996 | Journal of Crystal Growth1996，169，： | 1 |
| 10 | Approach to Short Stature显示文摘 | Sangeeta Y Aashima D | 2015 | The Indian Journal of Pediatrics2015，82，5： | 1 |
| 11 | Bmi-1 regulates the Ink4a/Arf locus to control pancreatic β-cell proliferation 显示文摘 | Sangeeta D Shuen Ing T Anil B | 2009 | Genes Dev2009，23，8： | 1 |
| 12 | A SERVQUAL and QFD Approach to Total Quality Education-A Student Perspective显示文摘 | Banwet D K Karunes S | 2004 | International Journal of Productivity and Performance Management2004，53，12： | 1 |
| 13 | Formulation of PEG-based hydrogel affects tissueengineered cartilage construct characteristics显示文摘 | SANGEETA D REBECCA D L | 2001 | Materials Science:Materials in Medicine2001，12，12： | 1 |
| 14 | Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock显示文摘 | James A. Russell Keith R. Walley Anthony C. Gordon D James Cooper Paul C. Hébert Joel Singer Cheryl L. Holmes Sangeeta Mehta John T. Granton Michelle M. Storms Deborah J. Cook Jeffrey J. Presneill | 2009 | Critical Care Medicine2009，，3： | 1 |
| 15 | Relative effects of Mo and B on ferrite and bainite kinetics in strong steels显示文摘 | Sangeeta Khare Kyooyoung Leeb H K D H | 2009 | International Journal of Materials Research2009，100，： | 1 |
| 16 | Metabolic sta- bility of plants regenerated from cryopreserved shoot tips of Dioscorea deltoidea Science Horticulturae an endangered medicinal plant显示文摘 | Sonali D S Sangeeta A G Binay B M | 2005 | Scientia Horticulturae2005，105，： | 1 |
| 17 | Molecular, pheno- typic and biosynthetic stability in Dioscorea floribunda plants derived from cryopreserved shoot tips显示文摘 | Sangeeta A Binay B M Sonali D | 2002 | plant sci- ence2002，163，： | 1 |
| 18 | Nanometersized ZrO2 particles prepared by a sol-emulsion-gel method显示文摘 | SANGEETA D RAMAMURT H | 1990 | American Ceramic Society1990，73，9： | 1 |
| 19 | A review of the higheoncentration capsacin patch and experience in its use in the management of neuropathic pain显示文摘 | GANESAN B SANGEETA D ARUN B | 2013 | Ther Adv Neurol Disord2013，6，： | 1 |
| 20 | Nanometer-sized ZrO2 paticles prepared by a sol-emulsion-gel method显示文摘 | | 1990 | J Am Ceram Soc1990，73，9： | 1 |
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