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| 1 | Complications of hip fractures: A review显示文摘Nowadays, fracture surgery represents a big part of the orthopedic surgeon workload, and usually has associated major clinical and social cost implications. These fractures have several complications. Some of these are medical, and other related to the surgical treatment itself. Medical complications may affect around 20% of patients with hip fracture. Cognitive and neurological alterations, cardiopulmonary affections(alone or combined), venous thromboembolism, gastrointestinal tract bleeding, urinary tract complications, perioperative anemia, electrolytic and metabolic disorders, and pressure scars are the most important medical complications after hip surgery in terms of frequency, increase of length of stay and perioperative mortality. Complications arising from hip fracture surgery are fairly common, and vary depending on whether the fracture is intracapsular or extracapsular. The main problems in intracapsular fractures are biological: vascularization of the femoral head, and lack of periosteum-a major contributor to fracture healing- in the femoral neck. In extracapsularfractures, by contrast, the problem is mechanical, and relates to load-bearing. Early surgical fixation, the role of anti-thromboembolic and anti-infective prophylaxis, good pain control at the perioperative, detection and management of delirium, correct urinary tract management, avoidance of malnutrition, vitamin D supplementation, osteoporosis treatment and advancement of early mobilization to improve functional recovery and falls prevention are basic recommendations for an optimal maintenance of hip fractured patients. | Pedro Carpintero Jose Ramón Caeiro Rocío Carpintero Angela Morales Samuel Silva Manuel Mesa | 2014 | World Journal of Orthopedics2014，5，4： | 31 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 4 | Optimization and kinetic studies for enzymatic hydrolysis and fermentation of colocynthis vulgaris Shrad seeds shell for bioethanol production显示文摘The key process parameters for the hydrolysis and fermentation of Colocynthis vulgaris Shrad seeds shell(CVSSS)were optimized using the Box-Behnken Design(BBD)of Response Surface Methodology(RSM).Kinetic study was also carried out.The proximate analysis of the CVSSS was done by the method of the Association of Organic and Applied Chemistry(AOAC).Enzymatic hydrolysis was experimented by using Aspergillus Niger as a crude enzyme isolated from soil at sawdust dump site and screened for cellulosic activities.Factors that affected the hydrolysis of the CVSSS were screened by using the Greco-Latin square design of experiment.However,for Saccharomyces cerevisiae,factors that affected the fermentation of the CVSSS were screened by using the same Greco-Latin square design of experiment.Meanwhile,the result of the proximate analysis revealed that the CVSSS had 73.54%cellulose which could be converted to bioethanol.It was established that temperature,pH and time had significant effect on hydrolysis,while the optimum results were obtained at 46.8℃,3.32 d,5.68 and 59.87%for temperature,time,pH and glucose yield,respectively.Temperature,yeast dosage,pH and time had significant effect on fermentation,while the optimum results from optimization were found to be 33.58℃,7.0,3.55 d,1.65 g per 50 mL and 25.6%for temperature,pH,time,yeast dosage and ethanol yield,respectively.The kinetics of both the enzymatic hydrolysis and fermentation agreed with the Michealis-Menten kinetic model with the correlation coefficients(R^(2))of 0.9708 and 0.8773,respectively.However,from the error analysis,the experimental and predicted values had a very good relationship as described by Michaelis-Menten model. | Igwilo Christopher Nnaemeka Egbuna Samuel O Onoh Maxwell I Asadu OChristain Onyekwulu Chinelo S | 2021 | Journal of Bioresources and Bioproducts2021，6，1： | 3 |
| 5 | Effect of Cold-Water Immersion on Skeletal Muscle Contractile Properties in Soccer Players显示文摘 | Juan Manuel García-Manso Darío Rodríguez-Matoso David Rodríguez-Ruiz Samuel Sarmiento Yves de Saa Javier Calderón | 2011 | American Journal of Physical Medicine & Rehabilitation2011，，5： | 2 |
| 6 | Neurotrophic fragments as therapeutic alternatives to ameliorate brain aging显示文摘Aging is a global phenomenon and a complex biological process of all living beings that introduces various changes.During this physiological process,the brain is the most affected organ due to changes in its structural and chemical functions,such as changes in plasticity and decrease in the number,diameter,length,and branching of dendrites and dendritic spines.Likewise,it presents a great reduction in volume resulting from the contraction of the gray matter.Consequently,aging can affect not only cognitive functions,including learning and memory,but also the quality of life of older people.As a result of the phenomena,various molecules with notable neuroprotective capacity have been proposed,which provide a therapeutic alternative for people under conditions of aging or some neurodegenerative diseases.It is important to indicate that in recent years the use of molecules with neurotrophic activity has shown interesting results when evaluated in in vivo models.This review aims to describe the neurotrophic potential of molecules such as resveratrol(3,5,4′-trihydroxystilbene),neurotrophins(brain-derived neurotrophic factor),and neurotrophic-type compounds such as the terminal carboxyl domain of the heavy chain of tetanus toxin,cerebrolysin,neuropeptide-12,and rapamycin.Most of these molecules have been evaluated by our research group.Studies suggest that these molecules exert an important therapeutic potential,restoring brain function in aging conditions or models of neurodegenerative diseases.Hence,our interest is in describing the current scientific evidence that supports the therapeutic potential of these molecules with active neurotrophic. | Itzel Ortiz Flores Samuel Treviño Alfonso Díaz | 2023 | Neural Regeneration Research2023，18，1： | 2 |
| 7 | Polycyclic aromatic hydrocarbons in sediments and soils from oil exploration areas of the Niger Delta, Nigeria显示文摘 | SAMUEL S O S WANG J Z SONIBARE O O | 2010 | Journal of hazardous materials2010，174，1： | 1 |
| 8 | ASPP proteins specificially stimulate the apoptotic function of p53 显示文摘 | SAMUELS LEV Y O'CONNOR D J BERGAMASCHI D | 2001 | Mol Cell2001，8，4： | 1 |
| 9 | Sonochemica| removal of nitric oxide from flue gases显示文摘 | SAMUEL O O YUSUF G A | 2006 | Ind Eng Chem Res2006，，45： | 1 |
| 10 | A standardized method for measuring intraeranial arterial stenosis显示文摘 | Samuels O B Joseph G J Lynn M J | 2000 | AJNR Am J Neuroradiol2000，21，4： | 1 |
| 11 | A morpho- logical and molecular perspective of Trichoderma viride: is it one or two species 显示文摘 | Lieckfeldt E Samuels G J Nirenberg H I Petrin O | 1999 | Appl Environ Microbiol1999，65，： | 1 |
| 12 | Fate ofpolybrominated diphenyl ethers in the environment of the Pearl RiverEstuary, South China显示文摘 | GUAN Y F SAMUEL SOJINU O S LI S M | 2009 | Environmental Pollution2009，157，7： | 1 |
| 13 | ASPP proteins specifically stimulate the apoptotic function of p53 显示文摘 | SAMUELS - LEV Y O 'CONNOR D J BERGAMASCHI D | 2001 | Mol Cell2001，8，： | 1 |
| 14 | Mutant PIK3CA promotes cell growth and invasion of human cancer ceils 显示文摘 | Samuels Y Diaz LA Jr Schmidt Kittler O | 2005 | Cancer Cell2005，7，6： | 1 |
| 15 | iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human显示文摘 | Bergamaschi D Samuels Y O'Neil N J | 2003 | Nat Genet2003，33，2： | 1 |
| 16 | When Outgroups Fail; Phylogenomics of Rooting the Emerging Pathogen, Coxiella burnetii显示文摘 | Talima Pearson Heidie M. Hornstra Jason W. Sahl Sarah Schaack James M. Schupp Stephen M. Beckstrom-Sternberg Matthew W. O’Neill Rachael A. Priestley Mia D. Champion James S. Beckstrom-Sternberg Gilbert J. Kersh James E. Samuel Robert F. Massung Paul Keim | 2013 | Systematic Biology2013，，5： | 1 |
| 17 | Red blood cell hemolysis during pro cessing 显示文摘 | Sowemino C Samuel O | 2002 | Transfuse Med Rev2002，16，1： | 1 |
| 18 | Personality disorders and normal personality dimensions in obsessive-compulsive disorder显示文摘 | Samuels J Nestadt G Bienvenu O J | 2000 | The British Journal of Psychiatry: The Journal of Mental Science2000，177，： | 1 |
| 19 | Regulation for conservatives : behavioral economics and the case for 'asymmetric paternalism' ( Preferences and Rational Choice : New Perspectives and Legal Implications) 显示文摘 | Colin Camerer Samuel Issacharoff George Loewenstein Ted O' Donoghue and Matthew Rabin | 2003 | University of Pennsylvania Law Review2003，，151： | 1 |
| 20 | 黄粉虫替代蛋白质饲料对太平洋白虾(凡纳滨对虾)消化性能的影响显示文摘试验旨在评估黄粉虫粉(MM)作为凡纳滨对虾养殖中蛋白质来源的可行性。饲料分为正常饲料和试验饲粮,试验饲料中包含正常饲料85%和MM 15%,两种饲料中均含有氧化铬0.5%作为惰性标记,试验采用表观消化率系数(ADC)对两种饲料进行检测。为评估MM消化价值,对虾饲料中采用鱼粉替代MM,替代比例分别为0%、25%、50%、75%和100%,在清水中饲养6周后,对生长参数和整个虾体成分进行评估。干物质ADC为45.9%,能量ADC为66.5%,粗蛋白质ADC为76.1%,必须氨基酸ADC为72%~86%。MM中蛋氨酸为第一限制性氨基酸。饲料中添加MM后,各组间对虾的体增重、特定生长率、采食量、饲料转化率、存活率和蛋白质合成率均无显著变化(P>0.05),虾体蛋白质含量无显著差异(P>0.05)。而随着鱼粉替代比例上升,虾体脂含量从1.13%升至1.88%。结果表明,黄粉虫粉可作为凡纳滨对虾饲料中的替代蛋白质饲料,但添加时应注意补充蛋氨酸。 | Panini R L Freitas L E L Guimarǎes A M Rios C da Silva M F O Vieira F N Fracalossi D M Samuels R I | 2017 | 饲料博览2017，0，7： | 1 |
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