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| 1 | Bone mineral density and disorders of mineral metabolism in chronic liver disease显示文摘AIM:To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with cirrhosis.METHODS:The study was performed on 72 Indian patients with cirrhosis(63 male, 9 female;aged < 50 years).Etiology of cirrhosis was alcoholism(n = 37), hepatitis B(n = 25) and hepatitis C(n = 10).Twenty-three patients belonged to Child class A, while 39 were in class B and 10 in class C.Secondary causes for metabolic bone disease and osteoporosis were ruled out.Sunlight exposure, physical activity and dietary constituents were calculated.Complete metabolic profiles were derived, and bone mineral density(BMD) was measured using dual energy X ray absorptiometry.Low BMD was defined as a Z score below-2.RESULTS:Low BMD was found in 68% of patients.Lumbar spine was the most frequently and severely affected site.Risk factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body mass.Calcium intake was adequate, with unfavorable calcium:protein ratio and calcium:phosphorus ratio.Vitamin D deficiency was highly prevalent(92%).There was a high incidence of hypogonadism(41%).Serum estradiol level was elevated significantly in patients with normal BMD.Insulin-like growth factor(IGF) 1 and IGF binding protein 3 levels were below the age-related normal range in both groups.IGF-1 was signiflcantly lower in patients with low BMD.Serum osteocalcin level was low(68%) and urinary deoxypyridinoline to creatinine ratio was high(79%), which demonstrated low bone formation with high resorption.CONCLUSION:Patients with cirrhosis have low BMD.Contributory factors are reduced physical activity, low lean body mass, vitamin D def iciency and hypogonadism and low IGF-1 level. | Joe George Hosahithlu K Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane Anjana Karvat Shobna J Bhatia Samir Shah Padmavathy S Menon Nalini Shah | 2009 | World Journal of Gastroenterology2009，15，28： | 15 |
| 2 | Circulating tumor and cancer stem cells in hepatitis C virusassociated liver disease显示文摘AIM:To assess the role of circulating tumor cells(CTCs)and cancer stem cells(CSCs)in hepatitis C virus(HCV)-associated liver disease.METHODS:Blood and/or tissue samples were obtained from HCV(genotype 4)-associated hepatocellularcarcinoma patients(HCC;n=120),chronic hepatitis C patients(CH;n=30)and 33 normal control subjects(n=33).Serum levels of alpha-fetoprotein(AFP),alkaline phosphatase,and alanine and aspartate aminotransferases were measured.Cytokeratin 19(CK19)monoclonal antibody was used to enumerate CTCs,and CD133 and CD90 were used to enumerate CSCs by flow cytometry.The expression levels of the CSCs markers(CD133 and CD90)as well as telomerase,melanoma antigen encoding gene 1(MAGE1)and MAGE3 were assessed by RTPCR and quantitative real-time polymerase chain reactions.The number of CTCs and/or the expression levels of CK19,CD133,telomerase,MAGE1 and MAGE3 were correlated to the standard clinicopathologic prognostic factors and disease progression.RESULTS:Levels of AFP,alkaline phosphatase and aspartate aminotransferase were significantly different among the HCC,CH and control groups(P<0.001),whereas alanine aminotransferase differed significantly between patient(HCC and CH)and control groups(P<0.001).At the specified cutoff values determine by flow cytometry,CK19(49.8),CD90(400)and CD133(73)were significantly higher in the blood of HCC patients compared to those in the CH and control groups(P<0.001).On the other hand,CD133 at a 69.5 cutoff was significantly higher in the CH compared to the control group(P≤0.001).Telomerase,MAGE1 and MAGE3RNA were expressed in 55.71%,60.00%and 62.86%of the HCC patients,respectively,but were not detected in patients in the CH or control groups,which were statistically significant(Ps<0.001).The expression levels of telomerase,CD90,MAGE3,CD133 and CK19 were all significantly associated with high tumor grade and advanced stage in HCC patients(all P s<0.05).CONCLUSION:CTC counts and AFP,CK19,telomerase,and MAGE1/MAGE3 expression predict disease progression in patients with HCV,whereas telomerase,MAGE3,CD90,CD133 and CK19 are prognostic mark- | Abeer A Bahnassy Abdel-Rahman N Zekri Ahmed El-Bastawisy Amal Fawzy Marwa Shetta Nehal Hussein Dalia Omran Abdallah A S Ahmed Samir S El-Labbody | 2014 | World Journal of Gastroenterology2014，20，48： | 9 |
| 3 | Multiple evolutionary origins of knockdown resistance ( kdr ) in pyrethroid-resistant Colorado potato beetle, Leptinotarsa decemlineata显示文摘 | Frank D. Rinkevich Cathy Su Tomás A. Lazo David J. Hawthorne Ward M. Tingey Samir Naimov Jeffrey G. Scott | 2012 | Pesticide Biochemistry and Physiology2012，，3： | 2 |
| 4 | Resonance energy transfer and ligand binding studies on pH-induced folded states of human serum albumin显示文摘 | AJAY K S SAMIR K P | 2008 | J Photochem Photobiol B2008，90，3： | 1 |
| 5 | Review of recent research into cellulosic whiskers,their properties and their application in nanocomposite field显示文摘 | Samir M A S A Alloin F Dufresne A | 2005 | Biomacromolecules2005，6，： | 1 |
| 6 | Computational study of natural ventilation 显示文摘 | Ayad Samir S | 1999 | Journal of Wind Engineering and Industrial Aerodynamics1999，82，8： | 1 |
| 7 | Lower Endoscopy and Prevention of Colon Cancer显示文摘 | Brigid S. Boland Jesús Rivera–Nieves Samir Gupta | 2014 | Gastroenterology2014，，： | 1 |
| 8 | Isothiocyanate from the Tunisian radish (Raphanus sativus) prevents genotoxieity of Zearalenone in vivo and in vitro 显示文摘 | Jalila B S A Samir A Zouhour O | 2009 | Mutation Research2009，677，： | 1 |
| 9 | Nanocomposite polymer electrolytes based on poly(oxyethylene) and cellulose nanocrystals显示文摘 | Samir M A S A Alloin F Gorecki W | 2004 | J Phys Chem B2004，108，10： | 1 |
| 10 | Tangling effect in fibrillated cellulose reinforced nanocomposites 显示文摘 | Azizi Samir M A S AUoin F Paillet M | 2004 | Macromolecules2004，37，11： | 1 |
| 11 | Temperature-dependent behaviour of dielectric properties of bound water in grain at microwave frequencies 显示文摘 | Trabelsi Samir Nelson S 0 | 2006 | Measurement Science and Tech- nology2006，17，： | 1 |
| 12 | Preparation of cellulose whiskers reinforced nanocomposites from an organic medium dispersion显示文摘 | Samir M A S A Alloin F Sanchez J-Y | 2004 | Macromolecules2004，37，： | 1 |
| 13 | Influence of non equilibratedwater on microwave dielectric properties of wheat and related errors in moisture sensing 显示文摘 | Trabelsi Samir Nelson S O | 2007 | IEEE Transactions on Instrumenta- tion and Measurement2007，56，1： | 1 |
| 14 | Model Predictive Control of Multilevel Cascaded H-Bridge Inverters显示文摘 | Patricio Cortés Alan Wilson Samir Kouro | | 0，，08： | 1 |
| 15 | Scar burden by myocardial perfusion imaging predicts echocardiographic response to cardiac resynchronization therapy in ischemic cardiomyopathy显示文摘 | Samir S | 2007 | Am Heart J2007，153，1： | 1 |
| 16 | Biomimefic foams of high mechanical performance based on nanostrnctured cell walls reinforced by native cellulose nanofibrils 显示文摘 | Svagan A J Samir M A S Berglund L A | 2008 | Advanced Materials2008，20，7： | 1 |
| 17 | A new cell secreting insulin显示文摘 | Sib S R Mohua M Samir B | 2003 | Endocrinology2003，4，144： | 1 |
| 18 | Effect of moisture and temperature on the mechanical properties of concrete显示文摘 | Samir N S Gergis W W Brian D | 2011 | Construction and Building Materials2011，25，2： | 1 |
| 19 | Finite element analysis of automotive cushion discs显示文摘 | Samir S Emmanuel B Fortin J | 2009 | Thin-Walled Structures2009，47，4： | 1 |
| 20 | Review of recent research into cellulosic whiskers, their properties and their application in nanocomposite field 显示文摘 | Samir M A S A Alloin F Dufresne A | 2005 | Biomacromole- curies2005，6，： | 1 |
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