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| 1 | Circulating tumor and cancer stem cells in hepatitis C virusassociated liver disease显示文摘AIM:To assess the role of circulating tumor cells(CTCs)and cancer stem cells(CSCs)in hepatitis C virus(HCV)-associated liver disease.METHODS:Blood and/or tissue samples were obtained from HCV(genotype 4)-associated hepatocellularcarcinoma patients(HCC;n=120),chronic hepatitis C patients(CH;n=30)and 33 normal control subjects(n=33).Serum levels of alpha-fetoprotein(AFP),alkaline phosphatase,and alanine and aspartate aminotransferases were measured.Cytokeratin 19(CK19)monoclonal antibody was used to enumerate CTCs,and CD133 and CD90 were used to enumerate CSCs by flow cytometry.The expression levels of the CSCs markers(CD133 and CD90)as well as telomerase,melanoma antigen encoding gene 1(MAGE1)and MAGE3 were assessed by RTPCR and quantitative real-time polymerase chain reactions.The number of CTCs and/or the expression levels of CK19,CD133,telomerase,MAGE1 and MAGE3 were correlated to the standard clinicopathologic prognostic factors and disease progression.RESULTS:Levels of AFP,alkaline phosphatase and aspartate aminotransferase were significantly different among the HCC,CH and control groups(P<0.001),whereas alanine aminotransferase differed significantly between patient(HCC and CH)and control groups(P<0.001).At the specified cutoff values determine by flow cytometry,CK19(49.8),CD90(400)and CD133(73)were significantly higher in the blood of HCC patients compared to those in the CH and control groups(P<0.001).On the other hand,CD133 at a 69.5 cutoff was significantly higher in the CH compared to the control group(P≤0.001).Telomerase,MAGE1 and MAGE3RNA were expressed in 55.71%,60.00%and 62.86%of the HCC patients,respectively,but were not detected in patients in the CH or control groups,which were statistically significant(Ps<0.001).The expression levels of telomerase,CD90,MAGE3,CD133 and CK19 were all significantly associated with high tumor grade and advanced stage in HCC patients(all P s<0.05).CONCLUSION:CTC counts and AFP,CK19,telomerase,and MAGE1/MAGE3 expression predict disease progression in patients with HCV,whereas telomerase,MAGE3,CD90,CD133 and CK19 are prognostic mark- | Abeer A Bahnassy Abdel-Rahman N Zekri Ahmed El-Bastawisy Amal Fawzy Marwa Shetta Nehal Hussein Dalia Omran Abdallah A S Ahmed Samir S El-Labbody | 2014 | World Journal of Gastroenterology2014，20，48： | 9 |
| 2 | 含酒精的肝炎的管理: 当前的概念显示文摘 Alcoholic hepatitis is a devastating form of acute liver injury seen in chronic alcohol abusers with significant morbidity and mortality.It is a multisystem disease that is precipitated by ingesting large quantities of alcohol with genetic and environmental factors playing a role.Prognostic criteria have been developed to predict disease severity and these criteria can serve as indicators to initiate medical therapy.Primary therapy remains abstinence and supportive care,as continued alcohol abuse is the most important risk factor for disease progression.The cornerstone of supportive care remains aggressive nutritional support,and although acute alcoholic hepatitis has been extensively studied,few specific medical therapies have been successful.Corticosteroids remain the most effective medical therapy available in improving short term survival in a select group of patients with alcoholic hepatitis;however,the long-term outcome of drug therapies is still not entirely clear and further clinical investigation is necessary.While liver transplantation for acute alcoholic hepatitis have demonstrated promising results,this practice remains controversial and has not been advocated universally,with most transplant centers requiring a prolonged period of abstinence before considering transplantation.Extracorporeal liver support devices,although still experimental,have been developed as a form of liver support to give additional time for liver regeneration.These have the potential for a significant therapeutic option in the future for this unfortunately dreadful disease. | Hetal A Karsan Samir Parekh | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 3 | Simulation in endoscopy:Practical educational strategies to improve learning显示文摘In gastrointestinal endoscopy, simulation-based training can help endoscopists acquire new skills and accelerate the learning curve. Simulation creates an ideal environment for trainees, where they can practice specific skills, perform cases at their own pace, and make mistakes with no risk to patients. Educators also benefit from the use of simulators, as they can structure training according to learner needs and focus solely on the trainee. Not all simulation-based training,however, is effective. To maximize benefits from this instructional modality,educators must be conscious of learners' needs, the potential benefits of training,and associated costs. Simulation should be integrated into training in a manner that is grounded in educational theory and empirical data. In this review, we focus on four best practices in simulation-based education: deliberate practice with mastery learning, feedback and debriefing, contextual learning, and innovative educational strategies. For each topic, we provide definitions,supporting evidence, and practical tips for implementation. | Rishad Khan Michael A Scaffidi Samir C Grover Nikko Gimpaya Catharine M Walsh | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，3： | 3 |
| 4 | Animal models of ex vivo lung perfusion as a platform for transplantation research显示文摘Ex vivo lung perfusion(EVLP) is a powerful experimental model for isolated lung research. EVLP allows for the lungs to be manipulated and characterized in an external environment so that the effect of specific ventilation/perfusion variables can be studied independent of other confounding physiologic contributions. At the same time,EVLP allows for normal organ level function and real-time monitoring of pulmonary physiology and mechanics. As a result,this technique provides uniqueadvantages over in vivo and in vitro models. Small and large animal models of EVLP have been developed and each of these models has their strengths and weaknesses. In this manuscript,we provide insight into the relative strengths of each model and describe how the development of advanced EVLP protocols is leading to a novel experimental platform that can be used to answer critical questions in pulmonary physiology and transplant medicine. | Kevin Nelson Christopher Bobba Samir Ghadiali Don Hayes Jr Sylvester M Black Bryan A Whitson | 2014 | World Journal of Experimental Medicine2014，4，2： | 2 |
| 5 | End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients显示文摘AIM To determine if end-stage renal disease (ESRD) is a risk factor for post endoscopic retrograde cholangio-pancreatography (ERCP) adverse events (AEs). METHODS We performed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of Diseases 9^(th) Revision (ICD-9-CM). Included patients were divided into three groups: ESRD, chronic kidney disease (CKD), and control. The primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICD-9-CM codes. Secondary outcomes were length of hospital stay, in-hospital mortality, and admission cost. AEs and mortality were compared using multivariate logistic regression analysis.RESULTS There were 492175 discharges that underwent ERCP during the 3 years. The ESRD and CKD groups contained 7347 and 39403 hospitalizations respectively, whereas the control group had 445424 hospitalizations. Post-ERCP pancreatitis (PEP) was significantly higher in the ESRD group (8.3%) compared to the control group (4.6%) with adjusted odd ratio (aOR) = 1.7 (95% CI: 1.4-2.1, ~aP < 0.001). ESRD was associated with significantly higher ERCP-related bleeding (5.1%) compared to the control group 1.5% (aOR = 1.86, 95%CI: 1.4-2.4, ~aP < 0.001). ESRD had increased hospital mortality 7.1% vs 1.15% in the control OR = 6.6 (95%CI: 5.3-8.2, ~aP < 0.001), longer hospital stay with adjusted mean difference (aMD) = 5.9 d (95% CI: 5.0-6.7 d, ~aP < 0.001) and higher hospitalization charges aMD = $+82064 (95%CI: $68221-$95906, ~aP < 0.001). CONCLUSION ESRD is a risk factor for post-ERCP AEs and is associated with higher hospital mortality. Careful selection and close monitoring is warranted to improve outcomes. | Tarek Sawas Fateh Bazerbachi Samir Haffar Won K Cho Michael J Levy John A Martin Bret T Petersen Mark D Topazian Vinay Chandrasekhara Barham K Abu Dayyeh | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 6 | Multicarrier PWM with DC-link ripple feedforward for multilevel inverters 显示文摘 | SAMIR K PABLO L MAURICIO A | 2008 | IEEE Trans Power Electron2008，23，1： | 1 |
| 7 | Review of recent research into cellulosic whiskers,their properties and their application in nanocomposite field显示文摘 | Samir M Alloin F Dufresne A | | 0，，2： | 1 |
| 8 | Effect of topical povidone-iodine versus topical ofloxacin on experimental Staphylococcus keratitis显示文摘 | Samir A Melki | 2000 | Lab investn2000，238，： | 1 |
| 9 | Review of recent research into cellulosic whiskers,their properties and their application in nanocomposite field显示文摘 | Samir M A S A Alloin F Dufresne A | 2005 | Biomacromolecules2005，6，： | 1 |
| 10 | Delayed sternal closure : a life - sav- ing measure in neonatal open heart surgery could it be predictable 显示文摘 | Samir K Riberi A Ghez O | 2002 | Eur J Cardiothorac Surg2002，21，5： | 1 |
| 11 | Isothiocyanate from the Tunisian radish (Raphanus sativus) prevents genotoxieity of Zearalenone in vivo and in vitro 显示文摘 | Jalila B S A Samir A Zouhour O | 2009 | Mutation Research2009，677，： | 1 |
| 12 | Nanocomposite polymer electrolytes based on poly(oxyethylene) and cellulose nanocrystals显示文摘 | Samir M A S A Alloin F Gorecki W | 2004 | J Phys Chem B2004，108，10： | 1 |
| 13 | Tangling effect in fibrillated cellulose reinforced nanocomposites 显示文摘 | Azizi Samir M A S AUoin F Paillet M | 2004 | Macromolecules2004，37，11： | 1 |
| 14 | A Fast Elitist Non-dominated Sorting Genetic Algorithm for Multiobjective Optimization:NSGA-II显示文摘 | Kalyanmoy D Samir A Amrit P | 2002 | IEEE Transactions on Evolutionary Computation2002，6，2： | 1 |
| 15 | Preparation of cellulose whiskers reinforced nanocomposites from an organic medium dispersion显示文摘 | Samir M A S A Alloin F Sanchez J-Y | 2004 | Macromolecules2004，37，： | 1 |
| 16 | p53-dependentexpression of the stress-induced protein ( SIP) 显示文摘 | Tomasini R Samir A A Pebusque M J ef al | 2002 | Eur J CellBiol2002，81，5： | 1 |
| 17 | High performance nanocomposite polymer electrolytes显示文摘 | Samir MASA Alloin F Dufresne A | 2006 | Composite Interfaces2006，13，46： | 1 |
| 18 | Biomimefic foams of high mechanical performance based on nanostrnctured cell walls reinforced by native cellulose nanofibrils 显示文摘 | Svagan A J Samir M A S Berglund L A | 2008 | Advanced Materials2008，20，7： | 1 |
| 19 | Review of Recent Research into CelluloSic Whiskers, Their Properties and Their Application in Nanocomposites Field显示文摘 | SAMIR MYASA ALLOIN F DUFRESNE A | 2005 | Biomacromolecules2005，6，2： | 1 |
| 20 | Delayed sternal closure:a life-saving measure in neonatal open heart surgery;could it be predictable?显示文摘 | Samir K Riberi A Ghez O | 2002 | Eur J Cardiothorae Surg2002，21，5： | 1 |
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