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| 1 | Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice显示文摘Background:Acetaminophen(APAP)overdose can cause liver injury and liver failure,which is one of the most common causes of drug-induced liver injury in the United States.Pharmacological activation of autophagy by inhibiting mechanistic target of rapamycin(mTOR)protects against APAP-induced liver injury likely via autophagic removal of APAP-adducts and damaged mitochondria.In the present study,we aimed to investigate the role of genetic ablation of mTOR pathways in mouse liver in APAP-induced liver injury and liver repair/regeneration.Methods:Albumin-Cre(Alb-Cre)mice,mTOR^(f/f) and Raptor^(f/f) mice(C57BL/6J background)were crossbred to produce liver-specific mTOR knockout(L-mTOR KO,Alb Cret/-,mTOR^(f/f))and liver-specific Raptor KO(L-Raptor,Alb Cret/-,Raptor^(f/f))mice.Alb-Cre littermates were used as wild-type(WT)mice.These mice were treated with APAP for various time points for up to 48 h.Liver injury,cell proliferation,autophagy and mTOR activation were determined.Results:We found that genetic deletion of neither Raptor,an important adaptor protein in mTOR complex 1,nor mTOR,in the mouse liver significantly protected against APAP-induced liver injury despite increased hepatic autophagic flux.Genetic deletion of Raptor or mTOR in mouse livers did not affect APAP metabolism and APAP-induced c-Jun N-terminal kinase(JNK)activation,but slightly improved mouse survival likely due to increased hepatocyte proliferation.Conclusions:Our results indicate that genetic ablation of mTOR in mouse livers does not protect against APAP-induced liver injury but may slightly improve liver regeneration and mouse survival after APAP overdose. | Hua Sun Hong-Min Ni Jennifer M.McCracken Jephte Y Akakpo Sam Fulte Tara McKeen Hartmut Jaeschke Hua Wang Wen-Xing Ding | 2021 | Liver Research2021，5，2： | 3 |
| 2 | Numerical simulations of morphological changes in barrier islands induced by storm surges and waves using a supercritical flow model显示文摘在这份报纸,一个先进明确的有限体积流动模型在二尺寸为模仿 supercritical 被介绍在一个潮汐 / 沿海的入口和障碍岛的沿海的流动和词法变化由于暴风雨巨浪和波浪。这个流动模型被结合存在波浪行动模型和沉积运输模型。结果综合沿海的过程模型能够模仿象快速的沿海的水流导致的波浪和波浪那样的极端条件导致的流动。这个发达 supercritical 流动模型与 Coriolis 力量,不平的深测术,风压力,和波浪放射压力的效果基于非线性的浅水方程的保守形式的答案。前面的 Euler 计划被用于不稳定的条款;并且对流条款是用与不一致的直线格子上的 HLL Riemann 解答者一起的 Godunov 类型 shockcapturing 计划的 discretized。发达模型的精确性被解决一个试验性的水坝裂缝测试用例调查。由于严重暴风雨攻击的突破的障碍岛,溢出和冲洗被模仿,联系到事件的预言的词法变化被分析在所有物理力量是在场的海岸调查模型的适用性。 | Soumendra Nath KUIRY Yan DING Sam S Y WANG | 2014 | Frontiers of Structural and Civil Engineering2014，8，1： | 2 |
| 3 | High expression of S-phase kinase-interacting protein 2,human F box protein,correlates with poor prognosis in oral squamous cell carcinomas显示文摘 | Kudo Y Kitajima S Sam S | 2001 | Cancer Research2001，61，19： | 1 |
| 4 | Heuristic approaches to vehicle routing with backhauls and time windows显示文摘 | Sam R T Jean Y P Tong S | 1996 | Computers and Operations Research1996，23，11： | 1 |
| 5 | An ionic liquid coating for determination of sildenafil and UK-103,320 in human serum by capillary zone electrophoresis-ion trap mass spectrometry显示文摘 | Qin Weidong Li Sam F Y | 2002 | Electrophoresis2002，23，24： | 1 |
| 6 | Preliminary Studies into the Behaviour of Knee Braced Frames Subject to Seismic Loading显示文摘 | Sam M T Liaw C Y | 1991 | Engineering Structures1991，13，： | 1 |
| 7 | A class of proportional in tegral sliding mode control with application to active suspension system显示文摘 | Sam Y M Osman H S Ghani M R | 2004 | Systems & Control Letters2004，51，3： | 1 |
| 8 | Structural stability of aluminum stabilized α nickel hydroxide as a positive electrode material for alkaline secondary batteries显示文摘 | DAI J X SAM LI Y | 2000 | Journal of Power Sources2000，89，： | 1 |
| 9 | Phylogenetic designa- tion of enterovirus 71 genotypes and subgenotypes using complete genome sequences 显示文摘 | Chan Y F Sam I C Abubakar S | 2010 | Infect Genet Evol2010，10，3： | 1 |
| 10 | Movable bed roughness in alluvial rivers 显示文摘 | Wu W M Wang Sam S Y | 1999 | Journal of Hydraulic Engineering ASCE1999，125，12： | 1 |
| 11 | Combining yeasts or a bacterial biocontrol agent and heat treatment to reduce postharvest decay of 'Gala'apples显示文摘 | Leverentz B Janisiewicz WJ Conway WS Saftner RA Fuchs Y Sams CE | 2000 | Postharvest biology and technology2000，21，1： | 1 |
| 12 | Autonomous Vehicle Positioning with GPS in Urban Canyon Environments 显示文摘 | CUI Y SAM S | 2003 | IEEE Transactions on RoBotics and Automation2003，19，1： | 1 |
| 13 | Rhoptry organdies of the apicomplexa: Their role in host cell invasion and intraeellular survival 显示文摘 | Sam - Yellowe T Y | 1996 | Parasitol Today1996，12，8： | 1 |
| 14 | Aptamer-mediated inhibition of Mycobacterium tuberculosis polyphosphate kinase 2显示文摘 | Shum K T Lui E L Wong S C Yeung P Sam L Wang Y | | 0，，： | 1 |
| 15 | Structural stability of aluminum stabilized alpha nickel hydroxide as a positive electrode material for alkaline secondary batteries显示文摘 | Jinxiang D Sam F Y L Danny X | 2000 | J Power Sources2000，89，1： | 1 |
| 16 | Low-temperature synthesized LiV3O8 as a cathode material for rechargeable lithium batteries显示文摘 | DAI J X SAM F Y L GAO Z Q SlOW K S | 1998 | J Electrochemical Society1998，145，9： | 1 |
| 17 | Key observations of liquefied batural gas vapor dispersion field test with expansion foam application显示文摘 | GEUNWOONG Y DEDY N SAM M M | 2011 | Industrial & Engineering Chemistry Research2011，50，： | 1 |
| 18 | Structural stability of aluminum stabilized alpha nickel hydroxide as a positive electrode material for alkaline secondary batteries显示文摘 | Dai Jin-xiang Li Sam F Y Xiao T D | 2000 | J Power Sources2000，89，： | 1 |
| 19 | Nonuniform sediment transport in alluvial rivers显示文摘 | Wu Weiming Wang Sam S Y Jia Yafei | 2000 | Journal of Hydraulic Research2000，38，6： | 1 |
| 20 | One dimensional modeling of dam-break flow over movable beds显示文摘 | Wu Weiming Sam S Y | 2005 | Journal of Hydraulic Engineering2005，133，1： | 1 |
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