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| 1 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 2 | Lymph node imaging in initial staging of prostate cancer:An overview and update显示文摘Accurate nodal staging at the time of diagnosis of prostate cancer is crucial in determining a treatment plan for the patient.Pelvic lymph node dissection is the most reliable method,but is less than perfect and has increased morbidity.Cross sectional imaging with computed tomography(CT) and magnetic resonance imaging(MRI) are non-invasive tools that rely on morphologic characteristics such as shape and size of the lymph nodes.However,lymph nodes harboring metastatic disease may be normal sized and non-metastatic lymph nodes may be enlarged due to reactive hyperplasia.The optimal strategy for preoperative staging remains a topic of ongoing research.Advanced imaging techniques to assess lymph nodes in the setting of prostate cancer utilizing novel MRI contrast agents as well as positron emission tomography(PET) tracers have been developed and continue to be studied.Magnetic resonance lymphography utilizing ultra-small super paramagnetic iron oxide has shown promising results in detection of metastatic lymph nodes.Combining MRL with diffusion-weighted imaging may also improve accuracy.Considerable efforts are being made to develop effective PET radiotracers that are performed using hybrid-imaging systems that combine PET with CT or MRI.PET tracers that will be reviewed in this article include [^(18)F]fluoro-D-glucose,sodium [^(18)F]fluoride,[^(18)F]choline,[^(11)C]choline,prostate specific membrane antigen binding ligands,[^(11)C]acetate,[^(18)F]fluciclovine,gastrin releasing peptide receptor ligands,and androgen binding receptors.This article will review these advanced imaging modalities and ability to detect prostate cancer metastasis to lymph nodes.While more research isneeded,these novel techniques to image lymph nodes in the setting of prostate cancer show a promising future in improving initial lymph node staging. | Jessica G Zarzour Sam Galgano Jonathan McConathy John V Thomas Soroush Rais-Bahrami | 2017 | World Journal of Radiology2017，9，10： | 5 |
| 3 | Primary phacoemulsification for uncontrolled angle-closure glaucoma 1 1 None of the authors has a financial or proprietary interest in any material or method mentioned.显示文摘 | Timothy V Roberts Ian C Francis Sam Lertusumitkul Medduma B Kappagoda Minas T Coroneo | 2000 | Journal of Cataract & Refractive Surgery2000，，7： | 3 |
| 4 | Quantitative trait loci controlling sulfur containing amino acids,methionine and cysteine,in soybean seeds显示文摘 | Panthee D R Pantalone V R Sams C E | 2006 | Theoretical and Applied Genetics2006，112，： | 1 |
| 5 | Seed quality QTL in a prominent soybean population显示文摘 | Hyten D L Pantalone V R Sams C E | 2004 | Theor App Genet2004，109，： | 1 |
| 6 | Quantitative trait loci controlling sulfur contsining amino acids,methionine and cysteine,in soybean seeds显示文摘 | Panthee D R Pantalone V R Sams C E | 2005 | Theor App Genet2005，112，： | 1 |
| 7 | Self cleaning photoactive TiO2 coatings on SLS glasses by sol-gel dip coating显示文摘 | Sam E D Urgen M Tepehan F Z Gunay V | 2004 | Key Engineering Materials2004，，： | 1 |
| 8 | Overexpression of the Bacillus thuringiensis (Bt) Cry2Aa2 protein in chloroplast confers resistance to plants against susceptible and Bt resistant insects 显示文摘 | MADHURI K HENRY D SAM V | 1999 | Proc NatlAcadSci USA1999，96，： | 1 |
| 9 | Dynamics of a stochastic Lotka - Volterra model perturbed by white noise 显示文摘 | Du N H Sam V H | 2006 | J Math Anal Appl2006，324，： | 1 |
| 10 | The shock index and the simplified PESI for identification of low-risk patients with acute pulmonary embolism 显示文摘 | Sam A Sanchez D G6mez V | 2011 | Eur Respir J2011，37，4： | 1 |
| 11 | Oxidative dehydro genation of propane over V-Mg-O catalysts显示文摘 | Slew Hew Sam D Soenen V Volta J C | 1990 | J Catal1990，123，2： | 1 |
| 12 | Seed quality QTL in a prominent soybean population显示文摘 | Hyten D L Pantalone V R Sams C E | 2004 | Theoretical and Applied ( enet- ies2004，109，： | 1 |
| 13 | Oxidative hydrogenation of propane over V-Mg-O catalysts显示文摘 | Sam DSH Soenen V Volta J C | 1990 | J Catal1990，123，： | 1 |
| 14 | Analysis of nozzle condensation dryingCycle 显示文摘 | Sam V Shelton Peter J Christiansen | 1999 | Applied Thermal Engineer- ing1999，19，： | 1 |
| 15 | Seed quality QTL in a prominent soybean population显示文摘 | Hyten D L Pantalone V R Sams C E | 2004 | Theoretical and Applied Genetics2004，109，： | 1 |
| 16 | Bioavailability of apomorphine following intranasal administration of mu_ coadhesive drug delivery systems in rabbits显示文摘 | Michael IU Sam E Norbert V | 1999 | Eur J Pharm Sci1999，9，： | 1 |
| 17 | Analysis of nozzle condensation drying cycle 显示文摘 | Sam V Shelton Peter J Christiansen | 1999 | Applied Thermal Engineering1999，19，： | 1 |
| 18 | Enzyme immunoassay of ampicillin in milk 显示文摘 | Sam sonova z V Shchelokova O S Ivanova N L | 2005 | Prlkl Biokhim Mikrobi-ol2005，41，6： | 1 |
| 19 | A Fourier-transform infrared spectroscopic analysis of organic matter degradation in a bench-scale solid substrate fermentation (composting) system 显示文摘 | Tseng D V Rahul V Sam J T | 1996 | Biotechnology and Bioengineering1996，52，6： | 1 |
| 20 | Seed quality QTL in a prominent soybean population显示文摘 | Hyten D L Pantalone V R Sams C E | 2004 | Theoretical and Applied Ge- netics2004，109，3： | 1 |
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