|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin显示文摘AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients. | Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C Espinós Josep M Viver Antonio Salas Fernando Fernández-Baares | 2013 | World Journal of Gastroenterology2013，19，26： | 13 |
| 2 | SYBR GreenⅠ染料法定量PCR检测疟原虫感染及显示文摘目的评价一种可以快速定量检测疟原虫及虫种鉴别的荧光定量PCR法。方法将SYBR Green Ⅰ法与TaqMan探针法检测疟原虫进行比对,评价定量的准确性及方法的敏感度。以PCR-DNA测序法为金标准,评价SYBR Green Ⅰ法分型的准确性。结果两个方法的定量拷贝检测数无显著性差异(P>0.05)。SYBR Green Ⅰ法检测疟原虫的最低检测下限为1×102copy/mL至5×102copy/mL之间。与PCR-DNA测序法比较,SYBR Green Ⅰ法能准确的对感染的疟原虫虫种做准确的鉴定。结论 SYBR Green I染料法定量可同时进行人体疟原虫的定量检测和虫种鉴别,且成本低廉,操作简便快速,可以在疟疾的高发地区推广使用。 | 陈江涛 刘配芬 钟德善 潘雪峰 杨辉 杨立业 陆志为 杨惠钿 林敏 Santiago-m Monte-Nguba Juan Carlos Salas Ehapo Urbano Monsuy Eyi | 2013 | 分子诊断与治疗杂志2013，5，4： | 11 |
| 3 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 4 | Updates in advanced diffusion-weighted magnetic resonance imaging techniques in the evaluation of prostate cancer显示文摘Diffusion-weighted magnetic resonance imaging(DWMRI) is considered part of the standard imaging protocol for the evaluation of patients with prostate cancer.It has been proven valuable as a functional tool for qualitative and quantitative analysis of prostate cancer beyond anatomical MRI sequences such as T2-weighted imaging. This review discusses ongoing controversies in DW-MRI acquisition, including the optimal number of b-values to be used for prostate DWI, and summarizes the current literature on the use of advanced DWMRI techniques. These include intravoxel incoherent motion imaging, which better accounts for the nonmono-exponential behavior of the apparent diffusion coefficient as a function of b-value and the influence of perfusion at low b-values. Another technique is diffusion kurtosis imaging(DKI). Metrics from DKI reflect excess kurtosis of tissues, representing its deviation from Gaussian diffusion behavior. Preliminary results suggest that DKI findings may have more value than findings from conventional DW-MRI for the assessment of prostate cancer. | Hebert Alberto Vargas Edward Malnor Lawrence Yousef Mazaheri Evis Sala | 2015 | World Journal of Radiology2015，7，8： | 11 |
| 5 | Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice显示文摘AIM: To study whether matrix metalloproteinase-9 (MMP-9) is a key factor in epithelial damage in the dextran sodium sulphate (DSS) model of colitis in mice.METHODS: MMP-9-deficient and wild-type (wt) mice were given 5% DSS in drinking water for 5 d followed by recovery up to 7 d. On d 5 and 12 after induction of colitis, gelatinases, MMP-2 and MMP-9, were measured in homogenates of colonic tissue by zymography and Western blot, whereas tissue inhibitor of metalloproteinases (TIMPs) were measured by reverse zymography. The gelatinolytic activity was also determined in supernatants of polymorphonuclear leukocytes (PMN) isolated from mice blood. Moreover, intestinal epithelial cells were stimulated with TNF-α to study whether these cells were able to produce MMPs. Finally, colonic mucosal lesions were measured by microscopic examination. RESULTS: On d 5 of colitis, the activity of MMP-9 was increased in homogenates of colonic tissues (0.24 ± 0.1 vs 21.3 ± 6.4, P < 0.05) and PMN from peripheral blood in wt (0.5 ± 0.1 vs 10.4 ± 0.7, P < 0.05), but not in MMP-9-deficient animals. The MMP-9 activity was also up-regulated by TNF-α in epithelial intestinal cells (2.5 ± 0.5 vs 14.7 ± 3.0, P < 0.05). Although colitis also led to increase of TIMP-1 activity, the MMP-9/TIMP-1 balance remained elevated. Finally, in the MMP-9-deficient colitic mice both the extent and severity of intestinal epithelialinjury were significantly attenuated when compared with wt mice. CONCLUSION: We conclude that DSS induced colitis is markedly attenuated in animals lacking MMP-9. This suggests that intestinal injury induced by DSS is modu-lated by MMP-9 and that inhibition of this gelatinase may reduce inflammation. | Alfredo Santana Carlos Medina Maria Cristina Paz-Cabrera Federico Díaz-Gonzalez Esther Farré Antonio Salas Marek W Radomski Enrique Quintero | 2006 | World Journal of Gastroenterology2006，12，40： | 9 |
| 6 | 抗草甘膦大豆的遗传研究显示文摘以 3个大面积推广的春大豆品种 (宁镇 3号、灰荚 2号和日本晴 3号 )为母本与 3个转基因抗草甘膦品种 (ARG4、ARG5和ARG6 )杂交 ,对杂交后代F1 、F2 、F3和BC1 的抗除草剂特性进行遗传分析 ,结果表明大豆对除草剂的抗性受一对显性核基因控制。 | 陈新 朱成松 顾和平 Francisco Firpo Carlos Sala | 2002 | 江苏农业科学2002，30，6： | 7 |
| 7 | 尿酸与新发左心室肥厚:来自PAMELA人群的发现显示文摘血清尿酸水平与左心室肥厚(left ventricular hypertrophy,LVH)的相关性存在争议,血尿酸预测LVH发生的作用目前尚不清楚。本研究对PAMELA(pressioni arteriose monitorate E loro associazioni)研究的受试者进行为期10年的随访以评估血清尿酸与新发LVH的关系。 | Cuspidi C Facchetti R Bombelli M Sala C Tadic M Grassi G Mancia G 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 6 |
| 8 | Inflammatory bowel diseases and human reproduction:A comprehensive evidence-based review显示文摘To evaluate the effects of inflammatory bowel diseases(IBDs)on human reproduction,we reviewed the current literature using a systematic search for published studies(articles and/or abstracts)without limits for English language.We searched on Medline(through PubMed),the Institute for Scientific Information,the Web of Science and the websites for the registration of controlled trials(http://gffzz872f90091fd340c7hf5vp0qcckbkv6kp6.ffgz.tsg.suse.edu.cn/).Bibliographies of retrieved articles,books,expert opinion review articles and reviewed bibliographies from subject experts were manually searched.Titles and abstracts were screened initially,and potential relevant articles were identified and reviewed.Whenever possible,data were analyzed by comparing IBD patients vs healthy controls,and patients with active IBDs vs those with disease in remission.The effects of IBDs on female fertility,fertility in infertile couples,pregnancy and male infertility were examined separately.Patients with IBDs in remission have normal fertility.At the moment,there is no established guideline for the preservation of fertility in women with IBD undergoing surgery.Further data are needed regarding guidelines for the management of these patients.Data regarding IBDs and infertility are currently completely lacking.Considering the prevalence of intestinal pathology in young adults of childbearing age,this field is of great scientific and clinical interest,opening up important future perspectives.Another important and as yet unexplored point is the response to treatments for infertility in patients with IBDs.In particular,the question is whether the reproductive outcomes(clinical and biological)can be influenced by the IBD of one of the partners.The goals for successful reproductive outcomes in IBD population are correct counseling and disease remission.IBDs significantly affect several reproductive aspects of human(female,male,couple)reproduction.Further data are needed to develop guidelines for the clinical management of subjects of reproductive age with IBDs. | Stefano Palomba Giuliana Sereni Angela Falbo Marina Beltrami Silvia Lombardini Maria Chiara Boni Giovanni Fornaciari Romano Sassatelli Giovanni Battista La Sala | 2014 | World Journal of Gastroenterology2014，20，23： | 6 |
| 9 | Potential advantages of acute kidney injury management by mesenchymal stem cells显示文摘Mesenchymal stem cells are currently considered as a promising tool for therapeutic application in acute kidney injury(AKI) management. AKI is characterized by acute tubular injury with rapid loss of renal function. After AKI, inflammation, oxidative stress and excessive deposition of extracellular matrix are the molecular events that ultimately cause the end-stage renal disease. Despite numerous improvement of supportive therapy, the mortality and morbidity among patients remain high. Therefore, exploring novel therapeutic options to treat AKI is mandatory. Numerous evidence in animal models has demonstrated the capability of mesenchymal stem cells(MSCs) to restore kidney function after induced kidney injury. After infusion, MSCs engraft in the injured tissue and release soluble factors and microvesicles that promote cell survival and tissue repairing. Indeed, the main mechanism of action of MSCs in tissue regeneration is the paracrine/endocrine secretion of bioactive molecules. MSCs can be isolated from several tissues, including bone marrow, adipose tissue, and blood cord; pre-treatment procedures to improve MSCs homing and their paracrine function have been also described. This review will focus on the application of cell therapy in AKI and it will summarize preclinical studies in animal models and clinical trials currently ongoing about the use of mesenchymal stem cells after AKI. | Francesca Bianchi Elisa Sala Chiara Donadei Irene Capelli Gaetano La Manna | 2014 | World Journal of Stem Cells2014，6，5： | 5 |
| 10 | 几种转基因植物体细胞克隆变异的多样性研究显示文摘分析了杨树、水稻和甘蔗转基因植株体细胞克隆的表型变异和基因组DNA多态性。探讨了以下问题 :转基因植株体细胞克隆的 1 )表型多样性 ,2 )基因组DNA多样性 ,3)二者的相关性 ,4)表型变异和DNA变异的可遗传特性 ,5)产生的可能原因 ,以及 6)在农业生产上的应用。 | 郑易之 Sala F | 2001 | 植物研究2001，21，2： | 5 |
| 11 | Gastric Cancer: Epidemiologic Aspects显示文摘 | Carlos A. González Núria Sala Theodore Rokkas | 2013 | Helicobacter2013，，： | 4 |
| 12 | G6PD缺陷症对恶性疟疾感染风险的影响显示文摘目的:观察葡萄糖-6-磷酸脱氢酶(G6PD)缺陷症不同表型对恶性疟原虫感染的影响。方法:采用横断面研究的方式,将2012年雨季到马拉博地区医院就诊的2 690名比奥克岛当地居民纳入研究。用显微镜镜检、荧光定量PCR结合熔解曲线法检测疟原虫。用荧光斑点法及PCR-DNA测序鉴定G6PD缺陷症。采用Logistic回归进行关联性分析。结果:该人群的G6PD缺陷症的总发生率为9.22%,基因型均为G6PD*A-(c.202 G>A/c.376 A>G)。G6PD缺陷症体现出强烈的疟疾保护作用(P<0.05);不同性别和表型的G6PD缺陷者中,只有男性半合子对疟疾有保护作用(P<0.05),而女性杂合子组与女性纯合子组均无统计学差异(P>0.05)。结论:G6PD缺陷症的男性半合子表型能够减低恶性疟疾感染的风险,但是其机制尚未明确,有待更深入的研究。 | 陈江涛 林敏 刘配芬 钟德善 谢东德 Santiago-m Monte-Nguba Juan Carlos Salas Ehapo Urbano Monsuy Eyi 杨立业 杨辉 詹小芬 杨惠钿 | 2014 | 实用医学杂志2014，30，21： | 4 |
| 13 | 伴有或不伴有肝实质侵犯的卵巢癌周围性转移CT检出的敏感性与特异性研究显示文摘目的回顾性确定由不同经验水平的放射医生读片时,伴有或不伴肝实质侵犯(LPI)的卵巢癌病人肝周围性转移CT鉴别的敏感性与特异性。研究以剖腹探查分期及病理检查为参考标准。方法学院医学伦理委员会批准此项研究不必签署知情同意书,研究符合HIPAA要求。121例卵巢癌病人(年龄29~94岁,平均57.8岁)纳入本研究。2位放射医生(放射医生1:6个月专业经验;放射医生2:2年6个月专业经验)在不知道病人临床资料情况下,相互独立地回顾性记录CT显示是否有周围性转移, | O. Akin E. Sala C.S. Moskowitz N. Ishill R.A. Soslow D.S. Chi 唐光健(译) | 2008 | 国际医学放射学杂志2008，31，5： | 4 |
| 14 | High density lipoproteins and atherosclerosis: emerging aspects显示文摘High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant anti-atherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis,includingmonocyte-macrophages, B and T lymphocytes.Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis. | Federica Sala Alberico Luigi Catapano Giuseppe Danilo Norata | 2012 | Journal of Geriatric Cardiology2012，9，4： | 4 |
| 15 | RAR Claus尾气处理工艺——能够满足最苛刻的炼厂环境要求的技术显示文摘由Technip KTI公司开发的RAR尾气处理技术是一种广为采用的还原型尾气处理技术,能够将炼厂的硫回收率提高到99.9%以上。基于RAR工艺改进的RAR MULTIPURPOSE技术将酸气富集技术与Claus尾气处理技术相结合,适用于处理硫化氢含量极低或含有Claus装置无法处理的杂质的原料。RAR MULTIPURPOSE技术能够提高贫酸气的硫化氢浓度,经富集后的气体便可用常规配置的Claus装置进行处理。重点描述了该工艺的主要特点、优点及在炼厂中的应用,并就如何将该工艺与现有的炼厂设备进行整合以优化投资和运营成本进行了探讨。 | Luciano Sala 尚珂 黄兴山 | 2009 | 中外能源2009，14，6： | 3 |
| 16 | Mapping paddy rice agriculture in southern China using multi-temporal MODIS images显示文摘 | Xiangming Xiao Stephen Boles Jiyuan Liu Dafang Zhuang Steve Frolking Changsheng Li William Salas Berrien Moore | 2005 | Remote Sensing of Environment2005，，4： | 3 |
| 17 | Intelligent windows for electricity generation: A technologies review显示文摘Buildings are responsible for over 40% of total primary energy consumption in the US and EU and therefore improving building energy efficiency has significant potential for obtaining net-zero energy buildings reducing energy consumption. The concurrent demands of environmental comfort and the need to improve energy efficiency for both new and existing buildings have motivated research into finding solutions for the regulation of incoming solar radiation, as well as ensuring occupant thermal and visual comfort whilst generating energy onsite. Windows as building components offer the opportunity of addressing these issues in buildings. Building integration of photovoltaics permits building components such as semi-transparent façade, skylights and shading devices to be replaced with PV. Much progress has been made in photovoltaic material science, where smart window development has evolved in areas such as semi-transparent PV, electrochromic and thermochromic materials, luminescent solar concentrator and the integration of each of the latter technologies to buildings, specifically windows. This paper presents a review on intelligent window technologies that integrate renewable energy technologies with energy-saving strategies contributing potential solutions towards sustainable zero-energy buildings. This review is a comprehensive evaluation of intelligent windows focusing on state-of-the-art development in windows that can generate electricity and their electrical, thermal and optical characteristics. This review provides a summary of current work in intelligent window design for energy generation and gives recommendations for further research opportunities. | Manlio Salas Castillo Xiao Liu Fedaa Abd-AIHamid Karen Connelly Yupeng Wu | 2022 | Building Simulation2022，15，10： | 3 |
| 18 | Phylogeography of SARS-CoV-2 pandemic in Spain:a story of multiple introductions,micro-geographic stratification,founder effects,and super-spreaders显示文摘Spain has been one of the main global pandemic epicenters for coronavirus disease 2019(COVID-19).Here,we analyzed>41000 genomes(including>26000 high-quality(HQ)genomes)downloaded from the GISAID repository,including 1245(922 HQ)sampled in Spain.The aim of this study was to investigate genome variation of novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and reconstruct phylogeographic and transmission patterns in Spain.Phylogeographic analysis suggested at least 34 independent introductions of SARS-CoV-2 to Spain at the beginning of the outbreak.Six lineages spread very successfully in the country,probably favored by super-spreaders,namely,A2 a4(7.8%),A2 a5(38.4%),A2 a10(2.8%),B3 a(30.1%),and B9(8.7%),which accounted for 87.9% of all genomes in the Spanish database.One distinct feature of the Spanish SARS-Cov-2 genomes was the higher frequency of B lineages(39.3%,mainly B3 a+B9)than found in any other European country.While B3 a,B9,(and an important sub-lineage of A2 a5,namely,A2 a5 c)most likely originated in Spain,the other three haplogroups were imported from other European locations.The B3 a strain may have originated in the Basque Country from a B3 ancestor of uncertain geographic origin,whereas B9 likely emerged in Madrid.The time of the most recent common ancestor(TMRCA)of SARS-CoV-2 suggested that the first coronavirus entered the country around 11 February 2020,as estimated from the TMRCA of B3 a,the first lineage detected in the country.Moreover,earlier claims that the D614 G mutation is associated to higher transmissibility is not consistent with the very high prevalence of COVID-19 in Spain when compared to other countries with lower disease incidence but much higher frequency of this mutation(56.4% in Spain vs.82.4% in rest of Europe).Instead,the data support a major role of genetic drift in modeling the micro-geographic stratification of virus strains across the country as well as the role of SARS-CoV-2 super-spreaders. | Alberto Gomez-Carballa Xabier Bello Jacobo Pardo-Seco Maria Luisa Perez del Molino Federico Martinon-Torres Antonio Salas | 2020 | Zoological Research2020，41，6： | 3 |
| 19 | Enhanced characterization of solid solitary pulmonary nodules with Bayesian analysis-based computer-aided diagnosis显示文摘The aim of this study was to prospectively assess the accuracy gain of Bayesian analysis-based computeraided diagnosis(CAD) vs human judgment alone in characterizing solitary pulmonary nodules(SPNs) at computed tomography(CT). The study included 100 randomly selected SPNs with a definitive diagnosis. Nodule features at first and follow-up CT scans as well as clinical data were evaluated individually on a 1 to 5 points risk chart by 7 radiologists, firstly blinded then aware of Bayesian Inference Malignancy Calculator(BIMC) model predictions. Raters' predictions were evaluated by means of receiver operating characteristic(ROC) curve analysis and decision analysis. Overall ROC area under the curve was 0.758 before and 0.803 after the disclosure of CAD predictions(P = 0.003). A net gain in diagnostic accuracy was found in 6 out of 7 readers. Mean risk class of benign nodules dropped from 2.48 to 2.29, while mean risk class of malignancies rose from 3.66 to 3.92. Awareness of CAD predictions also determined a significant drop on mean indeterminate SPNs(15 vs 23.86 SPNs) and raised the mean number of correct and confident diagnoses(mean 39.57 vs 25.71 SPNs). This study provides evidence supporting the integration of the Bayesian analysis-based BIMC model in SPN characterization. | Simone Perandini Gian Alberto Soardi Massimiliano Motton Raffaele Augelli Chiara Dallaserra Gino Puntel Arianna Rossi Giuseppe Sala Manuel Signorini Laura Spezia Federico Zamboni Stefania Montemezzi | 2016 | World Journal of Radiology2016，8，8： | 3 |
| 20 | The role of dynamic contrast-enhanced and diffusion weighted magnetic resonance imaging in the female pelvis显示文摘 | Evis Sala Andrea Rockall Deepa Rangarajan Rahel A. Kubik-Huch | 2010 | European Journal of Radiology2010，，3： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员