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| 1 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。 | Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec | 2017 | Protein & Cell2017，8，9： | 45 |
| 2 | Helicobacter pylori and autoimmune disease:Cause or bystander显示文摘Helicobacter pylori(H.pylori)is the main cause of chronic gastritis and a major risk factor for gastric cancer.This pathogen has also been considered a potential trigger of gastric autoimmunity,and in particular of autoimmune gastritis.However,a considerable number of reports have attempted to link H.pylori infection with the development of extra-gastrointestinal autoimmune disorders,affecting organs not immediately relevant to the stomach.This review discusses the current evidence in support or against the role of H.pylori as a potential trigger of autoimmune rheumatic and skin diseases,as well as organ specific autoimmune diseases.We discuss epidemiological,serological,immunological and experimental evidence associating this pathogen with autoimmune diseases.Although over one hundred autoimmune diseases have been investigated in relation to H.pylori,we discuss a select number of papers with a larger literature base,and include Sj grens syndrome,rheumatoid arthritis,systemic lupus erythematosus,vasculitides,autoimmune skin conditions,idiopathic thrombocytopenic purpura,autoimmune thyroid disease,multiple sclerosis,neuromyelitis optica and autoimmune liver diseases.Specific mention is given to those studies reporting an association of anti-H.pylori antibodies with the presence of autoimmune disease-specific clinical parameters,as well as those failing to find such associations.We also provide helpful hints for future research. | Daniel S Smyk Andreas L Koutsoumpas Maria G Myt-ilinaiou Eirini I Rigopoulou Lazaros I Sakkas Dimitrios P Bogdanos | 2014 | World Journal of Gastroenterology2014，20，3： | 12 |
| 3 | Cold dialysis and its impact on renal patients' health:An evidence-based mini review显示文摘Chronic renal disease is associated with advanced age,diabetes,hypertension,obesity,musculoskeletal problems and cardiovascular disease,the latter being the main cause of mortality in patients receiving haemodialysis(HD).Cooled dialysate(35 ℃-36 ℃) is recently employed to reduce the incidence of intradialytic hypotension in patients on chronic HD.The studies to date that have evaluated cooled dialysate are limited,however,data suggest that cooled dialysate improves hemodynamic tolerability of dialysis,minimizes hypotension and exerts a protective effect over major organs including the heart and brain.The current evidence-based review is dealing with the protective effect of cold dialysis and the benefits of it in aspects affecting patients' quality of care and life.There is evidence to suggest that cold dialysis can reduce cardiovascular mortality.However,large multicentre randomized clinical trials are urgently needed to provide further supporting evidence in order to incorporate cold dialysis in routine clinical practice. | Giorgos K Sakkas Argiro A Krase Christoforos D Giannaki Christina Karatzaferi | 2017 | World Journal of Nephrology2017，6，3： | 4 |
| 4 | Restless legs syndrome is contributing to fatigue and low quality of life levels in hemodialysis patients显示文摘AIM To examine whether hemodialysis(HD) patients with restless legs syndrome(RLS) are subjects of greater fatigue and impaired quality of life(QoL) compared to HD patients without RLS.METHODS Eighty five stable HD patients participated in this study. According to their RLS status, the patients were dividedinto the RLS group(n = 23) and the non-RLS group(n = 62). QoL, fatigue, sleep quality, daily sleepiness and depression symptoms were assessed by using various questionnaires. Finally, biochemical parameters including iron, ferritin, hemoglobin, hematocrit and parathormone were assessed. RESULTS The HD patients with RLS scored worse in all the questionnaires used in the study(P < 0.05). The patients with RLS were more likely to receive the HD therapy on the morning shift, whilst 43.5% of the RLS patients reported to experience the RLS symptoms also during HD. The severity of RLS was correlated with fatigue, depression score and sleep quality(P < 0.05). CONCLUSION HD patients with RLS are subject to lower QoL related parameters and greater fatigue compared to HD patients without RLS. RLS should be successfully managed in order to improve the QoL of the sufferers. | Christoforos D Giannaki Michael Hadjigavriel Akis Lazarou Aristos Michael Loukas Damianou Efthimios Atmatzidis Ioannis Stefanidis Georgios M Hadjigeorgiou Giorgos K Sakkas Marios Pantzaris | 2017 | World Journal of Nephrology2017，6，5： | 3 |
| 5 | Assessment of cardiac preload and extravascular lung water by single transpulmonary thermodilution显示文摘 | S. G. Sakka C. C. Rühl U. J. Pfeiffer R. Beale A. McLuckie K. Reinhart A. Meier-Hellmann | 2000 | Intensive Care Medicine2000，，2： | 2 |
| 6 | Classification algorithms for microcalcifications in mammograms (Review)显示文摘 | E. Sakka A. Prentza D. Koutsouris | 2006 | Oncology Reports2006，，4： | 2 |
| 7 | Assessment of cardiac preload and extravascular lung water by single transpulmonary thermodilution显示文摘 | SAKKA S G RUHL C C PFEIFFER U J | 2000 | Intensive Care Med2000，26，2： | 1 |
| 8 | Preparation of TiO2 coat- ing films containing Pd fine particles by sol - gel method 显示文摘 | Zhao G L Kozuka H Sakka S | 1995 | J Sol -Gel Sci Tech1995，4，： | 1 |
| 9 | Oligoclonal T cell expansion in the skin of patients with systemic sclerosis显示文摘 | Sakkas LI Xu B Artlett CM | 2002 | J Immunol2002，168，7： | 1 |
| 10 | Factors associated with early and late failure of dental implants显示文摘 | Sakka S Baroudi K Nassani MZ | 2012 | J Investig Clin Dent2012，3，4： | 1 |
| 11 | Nature of DNA damage in ejaculated human spermatozoa and the possi- ble involvement of apoptosis显示文摘 | SAKKAS D MOFFATT O MARIETHOZ GC | 2002 | Biol Rep rod2002，66，4： | 1 |
| 12 | Antimicrobial re- sistance of major foodborne pathogens from major meat prod- uets显示文摘 | Gousia P Eeonomou V Sakkas H | 2011 | Foodb Pathog Dis2011，，8： | 1 |
| 13 | Enrichment of anammox bacteria from marine environment for the con- struction of a bioremediation reactor显示文摘 | Nakajima J Sakka M Kimura T | 2008 | Applied Environ- mental and Microbiology2008，77，： | 1 |
| 14 | Assessment of cardiac preload and extravascular lung water by single transpulmonary themodilution显示文摘 | SAKKA S G RUHL C C PFEIFFER U J | | 0，，02： | 1 |
| 15 | Assisted reproduction and its neuroendocrine impact on the offspring显示文摘 | Kanaka-Gantenbein C Sakka S Chrousos GP | 2010 | Prog Brain Res2010，182，： | 1 |
| 16 | Photochemical degradation study of irgarol 1051 in natural waters: influence of humic and fulvic substances on the reaction显示文摘 | Vasilios A Sakkas Dimitra A Lambropoulou Triantafyllos A Albanis | 2002 | Journal of Photochemistry & Photobiology, A: Chemistry2002，，2： | 1 |
| 17 | Early cleavage of human embryos to the two- cell stage after intracytoplasmic sperm injection as an indicator of embryo viability显示文摘 | Sakkas D | 1998 | Hum Reprod1998，1827，： | 1 |
| 18 | Thermal modeling and heat manage- ment of supercapacitor modules for vehicle applications显示文摘 | SAKKA M A GUALOUS H | 2009 | Journal of Power Sources2009，194，： | 1 |
| 19 | Protein tyrosine phosphorylation in sperm during gamete interaction in the mouse: the influence of glucose显示文摘 | URNER F LEPPENS-LUISIER G SAKKAS D | 2001 | Biol Reprod2001，64，5： | 1 |
| 20 | Application of Microbial Genes to Recalcitrant Biomass Utilization and Environmental Conservation 显示文摘 | Kunio Ohmi Y A Kazuo Sakka Tetsuya Kimura | 2003 | Journal of Bioscience and Bioengineering2003，95，6： | 1 |
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