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| 1 | Rituximab for troublesome cases of childhood nephrotic syndrome显示文摘Nephrotic syndrome(NS) is the most common glomerular disease of childhood. Steroid-dependent and steroid-resistant nephrotic syndrome present challenges in their pharmaceutical management; patients may need several immunosuppressive medication for optimum control, each of which medication has its own safety profile. Rituximab(RTX) is a monoclonal antibody that targets B cells and has been used successfully for management of lymphoma and rheumatoid arthritis. Recent clinical studies showed that rituximab may be an efficacious and safe alternative for the treatment of complicated nephrotic syndrome. In this review article, we aim to review the efficacy and safety of RTX therapy in nephrotic syndrome. We reviewed the literature pertaining to this topic by searching for relevant studies on Pub Med and Medline using specific keywords. The initial search yielded 452 articles. These articles were then examined to ensure their relevance to the topic of research. We focused on multicenter randomized controlled trials with relatively large numbers of patients. A total of 29 articles were finally identified and will be summarized in this review. The majority of clinical studies of RTX in complicated pediatric NS showed that rituximab is effective in approximately 80% of patients with steroid-dependent NS, as it decreases the number of relapses and steroid dosage. However, RTX is less effective at achieving remission in steroid-resistant NS. RTX use was generally safe, and most side effects were transient and infusion-related. More randomized, double-blinded clinical studies are needed to assess the role of RTX in children with nephrotic syndrome. | Osama Y Safdar Adila Aboualhameael Jameela A Kari | 2014 | World Journal of Clinical Pediatrics2014，3，4： | 5 |
| 2 | Acute endurance exercise increases the nuclear abundance of PGC-lct in trained human skeletal muscle显示文摘 | Little JP Safdar A Cermak N | 2010 | Am J Physiol Regul Integr Comp PhysioL2010，298，91： | 1 |
| 3 | A practieal model of low- volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle:potential mechanisms 显示文摘 | LittLe JP Safdar A Wilkin GP | 2010 | J Physio12010，588，： | 1 |
| 4 | The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation:a systematic review and meta-analysis显示文摘 | Safdar N Said A Lucey MR | 2004 | Liver Transpl2004，10，： | 1 |
| 5 | Effect of Sorption on Co(Ⅱ),Cu(Ⅱ),Ni(Ⅱ) and Zn(Ⅱ) Ions Precipitation显示文摘 | Safdar M Mustafa S Naeem A | | 0，，1： | 1 |
| 6 | Prospective study of Candida species in patients at a comprehensive cancer center显示文摘 | Safdar A Chaturvedi V Cross EW | 2001 | Antimicrob Agents Chemother2001，45，7： | 1 |
| 7 | Applications of Ultrasound to Organic Chemistry 显示文摘 | Davidson R S Safdar A Spencer J D | 1987 | Ultrasonics1987，25，1： | 1 |
| 8 | Transverse testicular ectopia with persistent mullerian duct syndrome: a case report 显示文摘 | Rasool N Safdar CA Ahrnad A | 2012 | Pakistan Armed Forces Med J2012，6，： | 1 |
| 9 | Management of pulmonary arterial hypertension during pregnancy: a retrospective, multicenter experience 显示文摘 | Duarte A G Thomas S Safdar Z | 2013 | Chest2013，143，5： | 1 |
| 10 | Synergistic effect of a fun- gus, Fusarium semitectum , and a nematode, Tylenchulus semi- penetrans, on citrus decline 显示文摘 | Safdar A Javed N Khan S A | 2013 | Pakistan Journal of Zoology2013，45，3： | 1 |
| 11 | Management of pulmonary arterial hypertension during pregnancy: a retrospective, muhicenter experience显示文摘 | Duarte A G Thomas S Safdar Z | 2013 | Chest2013，143，5： | 1 |
| 12 | An acute bout of highintensity interval training increases the nuclear abundance of PGC-1αand activates mitochondrial biogenesis in human skeletal muscle显示文摘 | Little JP Safdar A Bishop D | 2011 | Am J Physiol Regul Integr Comp Physiol2011，300，6： | 1 |
| 13 | In vivo pharmacodynamic activity of daptomycin显示文摘 | Safdar N Andes D Craig W A | 2004 | Antimicrob Agents Chemother2004，48，： | 1 |
| 14 | Dose-related safety and immunogenicity of baculovirus - expressed trivalent influenza vaccine: a double-blind, controlled trial in adult patients with non- Hodgkin B cell lymphoma显示文摘 | Safdar A Rodriguez MA Fayad LE | 2006 | J Infect Dis2006，194，10： | 1 |
| 15 | Prospective study of Candida species in patients a comprehensive cancer center显示文摘 | SAFDAR A CHATRRVEDI V | 2001 | Antimicrob Agents Chemother2001，45，7： | 1 |
| 16 | A practical model of low-volume high-intensity interval training induces mitochon- drial biogenesis in human skeletal muscle: potential mecha- nisms 显示文摘 | Little JP Safdar A Wilkin GP | 2010 | J Physiol2010，588，6： | 1 |
| 17 | Antimicrobial activities against 84 listeria monocytogenes isolates from patients with systemic Listeriosis at a comprehensive cancer center(1955-1997) 显示文摘 | SAFDAR A | 2003 | J Clin Microbiol2003，1，： | 1 |
| 18 | A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: a meta-analytic/meta-regression study显示文摘 | Kumar A Safdar N Kethireddy S | 2010 | Crit Care Med2010，38，8： | 1 |
| 19 | The HAT score: a simple gTading scale for predicting hemorrhage after thrombolysis 显示文摘 | Lou M Safdar A Mehdiratta M | 2008 | Neurology2008，71，18： | 1 |
| 20 | Exercise Increases Mitochondrial PGC-1 alpha Content and Promotes Nuclear- Mitochondrial Cross-Talk to Coordinate Mitochondrial Biogenesis显示文摘 | Safdar A Little J P Stokl A J | 2011 | J Biol Chem2011，286，10： | 1 |
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