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| 1 | Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea显示文摘瞄准:估计酵母属 boulardii 的功效和安全(S。boulardii ) 在在减少腹泻的事件的频率在的尖锐水的腹泻和它的角色随后二个月。方法:从 2 瞬间的孩子到 12 岁,在 S 根据包括标准和随机的 ised 与尖锐腹泻被选择。boulardii 组(与 ORS,营养的支持和 S 一起对待。boulardii, 250 mg 出价) 并且在控制组(仅仅与 ORS 和营养的支持一起对待) 。直接疗法阶段是 5 d,每个孩子以后被跟随二个月。象药的安全一样的凳子的频率和一致性在每访问上被估计。二个组的比较以痢疾的事件的数字被做在随后二个月。结果:在每个组有五十个病人。象吝啬的年龄和凳子的平均频率那样的基线特征在 S 是可比较的。boulardii 和控制在试用在包括的时候组织。由 d 3 它分别地并且由 d 每 d 归结为 2.7 和 4.2 张凳子 6 它归结为 1.6 (S。boulardii 组) 并且 3.3 (控制组) 。腹泻的持续时间是在 S 的 3.6 d。而它是在控制组的 4.8 d, boulardii 组织(P = 0.001 ) 。在下列二个月内, S。有的 boulardii 组一显著地, 0.54 个事件的低频率作为与在控制的 1.08 个事件相比组织。这药很好被接受并且容忍。在治疗时期期间没有副作用的报告。结论:S。boulardii 显著地减少尖锐腹泻的频率和持续时间。凳子的一致性也改善。这药是容忍得好的。 | AG Billoo MA Memon SA Khaskheli G Murtaza Khalid Iqbal M Saeed Shekhani Ahson Q Siddiqi | 2006 | World Journal of Gastroenterology2006，12，28： | 22 |
| 2 | 基因工程FGF19类似物aldafermin治疗非酒精性脂肪性肝炎的效果和安全性显示文摘aldafermin是一种成纤维细胞生长因子19的工程类似物,可抑制胆汁酸的合成并调节代谢稳态。该研究报告了一项对非酒精性脂肪性肝炎(NASH)患者进行的一系列肝脏活检的为期24周的2期临床试验结果。 | HARRISON SA NEFF G GUY CD 张瑞华 温晓玉 | 2021 | 临床肝胆病杂志2021，37，3： | 22 |
| 3 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 4 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 5 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 6 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 7 | 胎盘生长因子抑制胎盘缺血引起的高血压显示文摘先兆子痫最有效的治疗是提前分娩出胎儿和胎盘。胎盘缺血的发生对先兆子痫发病有至关重要的影响,因为在动物或人类,子宫灌注压减少(reduced uterine perfusion pressure,RUPP)可诱发胎盘缺血/缺氧,刺激机体释放高血压胎盘因子进入母体循环。抗血管生成因子可溶性fms样酪氨酸激酶1(soluble fms-like tyrosine kinase-1,sFlt-1)可拮抗和减少有生物活性的血管内皮生长因子( vascular endothelial growth factor, VEGF)和胎盘生长因子( placental growth factor, PIGF),研究发现在RUPP大鼠和先兆子痫患者中,sFlt-1水平升高。 | 刘莉 叶鹏 Spradley FT Tan AY Joo WS Daniels G Kussie P Karumanchi SA Granger JP | 2016 | 中华高血压杂志2016，24，2： | 2 |
| 8 | Risk of seizures in survivors of newborn heart surgery using deep hypot hermic circulatory arrest 显示文摘 | Claney RR McC-aum SA Wernovsky G | 2003 | Pediatrics2003，111，3： | 1 |
| 9 | Results of treatment of 255 patients with metastatic renal cell carcinoma wtlo received high-dose recombinant interleukin-2 therapy 显示文摘 | Fyfe G Fisher RI Rosenberg SA | 1995 | J Clin Oncol1995，13，3： | 1 |
| 10 | Exhaled 8 - isoprostane as a new non - invasive biomarker of oxidative stress in cystic fibrosis显示文摘 | Montuschi P Kharitonov SA Ciabattoni G | 2000 | Thorax2000，55，： | 1 |
| 11 | Alcohol treatment, changes in coping skills, self-efficacy, and levels of alcohol use and related problems 1 year following treatment initiation显示文摘 | Maisto SA Connors G J Zywiak WH | 2000 | Psychol Addict Behav2000，14，3： | 1 |
| 12 | Mitochondrial control of apoptosis显示文摘 | Kroemer G Zamzami N Susin SA | 1997 | Immunol Today1997，18，： | 1 |
| 13 | Oxidants, antioxidants and carcino- genesis显示文摘 | Ray G Husain SA | 2002 | Indian J Exp Biol2002，40，11： | 1 |
| 14 | MyD88 drives the IFN-β response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7 显示文摘 | Weiss G Maaetoft-Udsen K Stifter SA | 2012 | J Immunol2012，9，6： | 1 |
| 15 | Optimization of FDG-PET/CT imaging protocol for evaluation of patients with primary and meta- static liver disease显示文摘 | Kuker RA Mesoloras G Gulec SA | 2007 | Int Semin Surg Oncol2007，4，： | 1 |
| 16 | Treatment of unstable thoracolumbar burst fractures by indirect reduction and posterior stabilization: short-segment versus long-segment stabilization 显示文摘 | Sapkas G Kateros K Papadakis SA | 2010 | Open Orthop J2010，4，2： | 1 |
| 17 | Gliomatosis cerebri radiologic correlation显示文摘 | Sliver SA Brown MT | 1995 | AJ NR1995，15，9： | 1 |
| 18 | Occult sacral fractures in osteopenic patients显示文摘 | Newhouse KE el-khoury G Buckwalter SA | 1992 | J Bone Joint Surg Am1992，74，10： | 1 |
| 19 | The Dornier Compact Delta lithotripter: the first 500 renal calculi显示文摘 | Lalak N J Moussa SA Smith G | 2002 | J Endourol2002，16，1： | 1 |
| 20 | Relationship between total and differential leukocyte counts and isolated coronary artery ectasia显示文摘 | Kocaman SA Taoy G Sahinarslan A | 2008 | Coron Artery Dis2008，19，5： | 1 |
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