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| 1 | p-Coumaric acid ameliorates ethanol-induced kidney injury by inhibiting inflammatory cytokine production and NF-κB signaling in rats显示文摘Objective: To examine the effects of p-coumaric acid on ethanol-induced kidney injury in Swiss Wistar rats.Methods: Ethanol(25% v/v) was used to induce nephrotoxicity in rats. p-Coumaric acid was orally administered at 50, 100, or 200 mg/kg body weight. The levels of oxidative parameters were determined; pro-inflammatory biomarkers were analyzed by Western blotting and apoptotic protein was analyzed by immunohistochemistry. Results: Ethanol treated rats showed decreased levels of antioxidants and aberrant production of pro-inflammatory cytokines(IL-6, IL1β, TNF-α), NF-κB activation and imbalance of proand anti-apoptotic proteins(Bcl-2, Bax, caspase 3). Meanwhile, p-coumaric acid restored antioxidant levels and decreased the levels of inflammatory cytokines, NF-κB, and proapoptotic proteins and increased Bcl-2 expression. Conclusions: p-Coumaric acid ameliorates ethanol-induced kidney injury by restoring antioxidant production and suppressing cellular apoptosis and inhibiting NF-κB expression.p-Coumaric acid should be further investigated as a promising candidate for ethanol-induced kidney toxicity. | Ramakrishnan Sabitha Kumari Nishi Vinoth Prasanna Gunasekaran Govindhan Annamalai Balupillai Agilan Mathan Ganeshan | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，5： | 2 |
| 2 | Zr(NO3)4:a versatile oxidizing agent for aromatization of Hantzsch 1,4-dihydropyridines and 1,3,5-trisubstituted pyrazolines显示文摘 | SABITHA G KUMAR-REDDY G S K REDDY C S | | 0，，： | 1 |
| 3 | Iodotrimethylsi- lane-accelerated one-pot synthesis of 5-unsubstituted 3,4- dihydropyrimidin-2 (IH)-ones: a novel procedure for the Biginelli-like cycloeondensation reaction at room tempera- ture 显示文摘 | Sabitha G Reddy K B Srinivas R | 2005 | Heir Chim Acta2005，88，11： | 1 |
| 4 | RSC Advance显示文摘 | Sabitha G Reddy D V Reddy S S S Yadav J S Kumar C G Sujitha P | 2012 | 2(8):72412012，2，8： | 1 |
| 5 | Influence of spices on the bacterial (enzyme) activity in experimental colon cancer 显示文摘 | Nalini N Sabitha K Viswanathan P | 1998 | Journal of Ethnopharmaeology1998，62，1： | 1 |
| 6 | Cerium (III)chloride promoted highly regioselective ring opening of ep-oxides and aziridines using NaN3 in acetonitrile : a facilesynthesis of 1,2-azidoaicohols and 1,2-azidoamines 显示文摘 | Sabitha G Babu R S Rajkumar M | 2002 | Org Lett2002，4，3： | 1 |
| 7 | Identification of small molecule inhibitors against UBE2C by using docking studies 显示文摘 | Sabitha K Rajkumar T | 2012 | Bioinformation2012，8，21： | 1 |
| 8 | Oxidant and antioxidant activity changes in patients with oral cancer and treated with radiotherapy显示文摘 | SABITHA K E SHYAMALADEVI C S | 1999 | Oral Oncol1999，35，3： | 1 |
| 9 | A novel, efficient,and selective cleavage of alkyltert-butyldimethylsilyl ethers using the BiC13/ NaI system显示文摘 | Sabitha G Babu R S Reddy E V | 2001 | Advanced Synthesis b- Catalysis2001，343，2： | 1 |
| 10 | Daucus carota and baker's yeast mediated bio-reduction of prochiral ketones 显示文摘 | YADAV J S REDDY G SABITHA G | 2007 | Tetrahedron: Asymmetry2007，18，6： | 1 |
| 11 | Chemopreventive and therapeutic modulation of green tea polyphenols on drug metabolizing enzymes in 4-Nitroquinoline 1-oxide induced oral cancer显示文摘 | Periasamy Srinivasan Subramaniyan Suchalatha Pon Velayutham Anandh Babu Rethinam Sundaresan Devi Shoba Narayan Kuruvimalai Ekambaram Sabitha Chennam Srinivasulu Shyamala Devi | 2008 | Chemico-Biological Interactions2008，，3： | 1 |
| 12 | Daucus carota and baker's yeast mediated bio - reduction of prochiral ketones 显示文摘 | Yadav J S Reddy G Sabitha G | 2007 | Tetrahed- ton : Asymmetry2007，18，： | 1 |
| 13 | Health bene- fits and clinical impact of major nutrient, red yeast rice: A review 显示文摘 | KALAIVANI M SABITHA R KALAISELVAN V | 2010 | Food Biopr Teehnol2010，，3： | 1 |
| 14 | 查看详情显示文摘 | Sabitha G Reddy G.S.K Reddy C.S Yadav J.S | | 0，，： | 1 |
| 15 | Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats显示文摘 | Vijaimohan K Mallika J Sabitha K E | 2006 | Life Sci2006，79，5： | 1 |
| 16 | Role of mangiferin on biochemical alterations and antioxidant status in isoproterenol-induced myocardial infarction in rats 显示文摘 | Prabhu S Jainu M Sabitha K E | 2006 | J Ethnopharm2006，107，1： | 1 |
| 17 | Esthetic evaluation of the treated unilateral cleft lip using photographs and image analysis software:A retrospective study显示文摘 | Sabitha S Veerabahu M Vikraman B | 2011 | J Maxillofac Oral Surg2011，10，3： | 1 |
| 18 | Aromatization of hantasch 1,4-dihydropyridines with I2- MeOH 显示文摘 | YADAV J S SUBBA REDDY B V SABITHA G | 2000 | Synthesis2000，，11： | 1 |
| 19 | Screening of plant species for the presence of antiviral principles against okra yellow vein mosaic virus 显示文摘 | Pun KB Sabitha D Jeyarajan R | 1999 | Indian JPhytopathol1999，52，3： | 1 |
| 20 | Ring opening of cyclic anydrides: Synthesis of achiral half - esters using lewis acids 显示文摘 | SABITHA G SRIVIDYA R YADAY J S | 1999 | Tetrahedron1999，55，： | 1 |
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