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| 1 | Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells显示文摘Artemisinin 对药抵抗的疟疾的寄生虫是高度有效的,它将近影响全球人口和杀死的一半 > 500 000 个人每年。artemisinin 的主要费用是过去常从 Artemisia annua 提取并且净化这药的昂贵的过程。这显然不必要的步的消除将在地方性的区域使这有势力抗疟药药买得起到全球人口生活。这里,我们报导了非蛋白质药 artemisinin biosynthesized 的口头的交货(0.8 mg/g 干燥重量) 在在由设计二的烟草的临床上有意义的层次,新陈代谢的小径指向了到三不同细胞的分隔空间(叶绿体,原子核,和线粒体) 。二倍地转基因的线显示出 isopentenyl 焦磷酸盐的三方面的改进,并且指向 AACPR, DBR2,和 CYP71AV1 到叶绿体导致了更高的表示和 dihydroartemisinic 酸的有效相片氧化到 artemisinin。从转基因的烟草植物的叶子的部分净化的摘录在变形体感染 falciparum 的红血房间的 vitro 生长前进禁止了。artemisinin 减少了的整个未经触动的植物房间 bioencapsulating 的口头的喂在与商业药比较的质问老鼠的 parasitemia 层次。如此的新奇 synergistic 途径应该通过可食的植物的新陈代谢的工程便于 artemisinin 和另外的药的便宜生产和交货。 | Karan Malhotra Mayavan Subramaniyan Khushboo Rawat Md. Kalamuddin M. Irfan Qureshi Pawan Malhotra Asif Mohmmed Katrina Cornish Henry Daniell Shashi Kumar1 | 2016 | Molecular Plant2016，9，11： | 14 |
| 2 | Multi-modality imaging review of congenital abnormalities of kidney and upper urinary tract显示文摘Congenital abnormalities of the kidney and urinary tract(CAKUT) include a wide range of abnormalities ranging from asymptomatic ectopic kidneys to life threatening renal agenesis(bilateral). Many of them are detected in the antenatal or immediate postnatal with a significant proportion identified in the adult population with varying degree of severity. CAKUT can be classified on embryological basis in to abnormalities in the renal parenchymal development, aberrant embryonic migration and abnormalities of the collecting system. Renal parenchymal abnormalities include multi cystic dysplastic kidneys, renal hypoplasia, number(agenesis or supernumerary), shape and cystic renal diseases. Aberrant embryonic migration encompasses abnormal location and fusion anomalies. Collecting system abnormalities include duplex kidneys and Pelvi ureteric junction obstruction. Ultrasonography(US) is typically the first imaging performed as it is easily available, noninvasive and radiation free used both antenatally and postnatally. Computed tomography(CT) and magnetic resonance imaging(MRI) are useful to confirm the ultrasound detected abnormality, detection of complex malformations, demonstration of collecting system and vascular anatomy and more importantly for early detection of complications like renal calculi, infection and malignancies. As CAKUT are one of the leading causes of end stage renal disease, it is important for the radiologists to be familiar with the varying imaging appearances of CAKUT on US, CT and MRI, thereby helping in prompt diagnosis and optimal management. | Subramaniyan Ramanathan Devendra Kumar Maneesh Khanna Mahmoud Al Heidous Adnan Sheikh Vivek Virmani Yegu Palaniappan | 2016 | World Journal of Radiology2016，8，2： | 13 |
| 3 | Hesperetin conjugated PEGylated gold nanoparticles exploring the potential role in anti-inflammation and anti-proliferation during diethylnitrosamine-induced hepatocarcinogenesis in rats显示文摘Liver cancer is the fifth most common cancer and one of the leading causes of death in the world, and second most common cause of death in men. Natural products emerge as the most enduring approaches in the development of anticancer targeting drug. Hesperetin(HP), one of the abundant flavonoids found naturally in citrus fruits, has received considerable attention in anti-cancer promotion and progression. The present study was conducted to decipher the role of 0.5 ml hesperetin conjugated gold nanoparticles(Au-m PEG(5000)-S-HP NPs) during diethylnitrosamine(DEN)-induced hepatocarcinogenesis in male Wistar albino rats and shows the better antioxidant that possesses anti-inflammatory,anti-proliferation and anticarcinogenic properties and may modulate signaling pathways.The confirmation of polymer functionalized gold nanoparticles and drug loaded polymer gold nanoparticles were characterized by HR-TEM with EDAX, and DLS with Zeta potential techniques. The drug encapsulation efficiency and release properties were carried out in PBS at pH 7.4 for Au-mPEG(5000)-S-HP and compared with the control pure hesperetin(HP).Here, we review the role of mast cell counts, tumor necrosis factor alpha(TNF-α), transcription factor nuclear factor-κB(NF-κB), levels of glycoconjugates, proliferating cell nuclear antigen(PCNA) and argyrophilic nucleolar organizing regions, are the master regulator of inflammation and proliferation, in the development of hepatocellular injury, liver fibrosis and HCC. DEN-administered animals showed increased mast cell counts, tumor necrosis factor alpha, transcription factor nuclear factor-κB, glycoconjugates, proliferating cell nuclear antigen, and argyrophilic nucleolar organizing regions. Whereas Au-mPEG(5000)-S-HP NPs supplementation considerably suppressed all the above abnormalities. These results suggest that the Au-m PEG(5000)-S-HP NPs exhibited the better potential anticancer activity by inhibiting cell inflammation and proliferation in DEN-induced hepatocellular carcinogenesis. | Gokuladhas Krishnan Jayakumar Subramaniyan Pramila Chengalvarayan Subramani Barath Muralidharan Devaki Thiruvengadam | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 4 |
| 4 | Molecular modeling studies of repandusinic acid as potent small molecule for hepatitis B virus through molecular docking and ADME analysis显示文摘Background:Hepatitis B virus(HBV)has affected over 300 million people worldwide which causes to induce mostly liver disease and liver cancer.It is a member of the family Hepadnaviridae which is a small DNA virus with unusual characters like retroviruses.Generally,hepatoprotective drugs provoke some side effects in human beings.For the reason,this study aims to identify alternative drug molecules from the natural source of medicinal plants with smaller quantity of side effects than those conventional drugs in treating HBV.Methods:We developed computational methods for calculating drug and target binding resemblance using the Maestro v10.2 of Schrodinger suite.The target and ligand molecules were obtained from recognized databases.Ligand molecules of 40 phytoconstituents were retrieved from variety of plants after we executed crucial analyses such as molecular docking and absorption,distribution,metabolism,and excretion(ADME)analysis.Results:In the docking analysis,the natural analogues repandusinic acid showed better docking scores of-14.768 with good binding contacts.The remaining bioactive molecules corilagin,furosin,nirurin,iso-quercetin and gallocatechin also showed better docking scores.Conclusions:This computational analysis reveals that repandusinic acid is a suitable drug candidate for HBV.Therefore,we recommend that this analogue is suitable in further exploration using in vitro studies. | Vijayakumar Subramaniyan Reetha Sekar Arulmozhi Praveenkumar Rajalakshmi Selvam | 2019 | Quantitative Biology2019，7，4： | 2 |
| 5 | Biotechnology of microbial xylanase:enzymology,molecular biology and application显示文摘 | Subramaniyan S Prema P | 2002 | Critical Reviews in Biotechnology2002，22，1： | 1 |
| 6 | GEMS:Gossip-enabled monitoring service for scalable heterogeneous distributed systems显示文摘 | Rajagopal Subramaniyan Pirabhu Raman Alan D George | 2006 | Cluster Computing2006，9，1： | 1 |
| 7 | Biotechnology of microbial xylanases:enzymology,molecular biology,and application显示文摘 | Subramaniyan S Prema P | 2002 | Critical Review in Biotechnology2002，22，1： | 1 |
| 8 | Biotechnology of microbial xy- lanases : enzymology, molecular biology, and application 显示文摘 | Subramaniyan S Prema P | 2002 | Crit Rev Biotechnol2002，22，1： | 1 |
| 9 | Biotechnology of micro- bial xylanases: enzymology, molecular biology, and application显示文摘 | SUBRAMANIYAN S PREMA P | 2002 | Critical Review in Biotechnology2002，22，1： | 1 |
| 10 | Microbial community in conventional and extended aeration activated sludge plants in India显示文摘 | Tyagi V K Subramaniyan S Kazmi A A | 2008 | Ecological Indicators2008，8，5： | 1 |
| 11 | Biotechnology of microbial xylanases:enzymology,molecular biology,and application显示文摘 | SUBRAMANIYAN S PREMA P | 2002 | CriticalReviews in Biotechnology2002，22，1： | 1 |
| 12 | Influence of experimental type 1 diabetes on the pulmonary effects of diesel exhaust particles in mice显示文摘 | NEMMAR A AL-SALAM S SUBRAMANIYAN D | 2013 | Toxicol Lett2013，217，2： | 1 |
| 13 | Antimicrobial and antiproliferative prospective of kosinostatin-a secondary metabolite isolated from Streptomyces sp.显示文摘Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate antimicrobial and anticancer potential of kosinostatin on mammary carcinoma cell line(MCF-7). The anticancer and antiproliferative activities of kosinostatin were analyzed on MCF cell line by MTT assay and cytotoxicity assays like lactate dehydrogenase(LDH) and glutathione(GSH). The secondary metabolite kosinostatin exhibited its apoptotic nature by expressing p53 protein. Collectively, the results acquired from this study promise that kosinostatin shows the potent anticancer activity. | Vinayagam Rambabu Subramaniyan Suba Suburamaniyan Vijayakumar | 2015 | Journal of Pharmaceutical Analysis2015，5，6： | 1 |
| 14 | Biotechnology of microbial xylanases: enzymology, molecular biology, and application 显示文摘 | Subramaniyan S Prema P | 2002 | Crit Rev Biotechnol2002，22，1： | 1 |
| 15 | Biotechnology of Microbial Xy- lanases: Enzymology, Molecular Biology, and Application 显示文摘 | Subramaniyan S Prema P | 2002 | Critical Reviews in Biotechnology2002，22，1： | 1 |
| 16 | Chemopreventive and therapeutic modulation of green tea polyphenols on drug metabolizing enzymes in 4-Nitroquinoline 1-oxide induced oral cancer显示文摘 | Periasamy Srinivasan Subramaniyan Suchalatha Pon Velayutham Anandh Babu Rethinam Sundaresan Devi Shoba Narayan Kuruvimalai Ekambaram Sabitha Chennam Srinivasulu Shyamala Devi | 2008 | Chemico-Biological Interactions2008，，3： | 1 |
| 17 | Cellulase-free xylanases from Bacillus and other microorganisms显示文摘 | Subramaniyan S Prema P | 2000 | FEMS Microbiology Letters2000，183，1： | 1 |
| 18 | Cellulase free xylanases from Bacillus and other microorganisms 显示文摘 | SUBRAMANIYAN S PREMA P | 2000 | FEMS Mlcroblol Lett2000，183，1： | 1 |
| 19 | Biotechnology ofMicrobial Xylanases: Enzymology Molecular Biology and Application显示文摘 | Subramaniyan S Prema P | 2002 | Critical Reviews in Biotechnology2002，22，1： | 1 |
| 20 | Cellulase-free xylanases from Bacillus and other microorganisms显示文摘 | Subramaniyan S Prema P | 2000 | FEMS Microbiol Lett2000，183，： | 1 |
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