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| 1 | 西班牙医学肿瘤学会(SEOM)实体肿瘤骨转移临床指南(2016)显示文摘恶性肿瘤骨转移常见于许多进展性实体肿瘤,尤其以乳腺、前列腺、甲状腺、肺、肾等部位发生的恶性肿瘤最为多见。骨转移将导致骨相关事件(SREs),即发生病理性骨折、脊髓受压、需行骨放疗或骨科手术、伴发高钙血症等情况,患者出现疼痛和功能障碍,生活质量受到负面影响。临床上需要通过几种影像学技术来明确骨转移诊断。骨靶向治疗包括强效双磷酸盐制剂——唑来膦酸和抗核因子κB受体激动剂配体(RANKL)单克隆抗体药物——狄诺塞麦(denosumab),二者均可降低多种类型肿瘤发生SREs的风险或延迟其进展;镭223是一种α粒子发射源,能够提高激素抵抗性前列腺癌骨转移患者的总存活率;必要时需采取包括骨科手术及放射治疗在内的多科协同疗法。西班牙医学肿瘤学会(Sociedad Espa?ola de Oncología Médica,SEOM)发表的这一指南对骨转移的发病机理、临床表现、实验室检查、影像学诊断与疗效评估、骨靶向制剂以及放疗、手术等局部治疗进行综述,在此基础上为骨转移患者的治疗提供推荐性意见。 | Grávalos C Rodríguez C Sabino A 白朝晖 陈旭琼 | 2017 | 中国骨科临床与基础研究杂志2017，9，1： | 10 |
| 2 | Probing the mechanism of the Heck reaction with arene diazonium salts by electrospray mass and tandem mass spectrometry 显示文摘 | SABINO A A MACHADO A H L ROQUE C D | 2004 | Angew Chem Int Ed2004，43，19： | 1 |
| 3 | Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil显示文摘 | Sabino E C Shpaer E G Morgado M G | 1994 | J Virol1994，68，： | 1 |
| 4 | Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD1839(Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor显示文摘 | Fortunato C Rosa C Roberto B Vincenzo D Grazia P Sabino De Placido | 2000 | Clin Cancer Res2000，6，： | 1 |
| 5 | Crystallization and preliminary X-ray study of saporin, a ribosome-inactivating protein from Saponaria officinalis 显示文摘 | SABINO C FEDERICI L BRANCACCIO A | 1998 | Acta crystallographica1998，54，4： | 1 |
| 6 | The crystal structure of saporin SO6 from Saponaria officinalis and its interaction with the ribosome 显示文摘 | SABINO C FEDERICI L IPPOLITI R | 2000 | FEBS letters2000，，3： | 1 |
| 7 | Genomewide association study (GWAS) of Chagas cardiomyopathy inTrypanosoma cruzi seropositive subjects显示文摘 | DENG X T SABINO E C CUNHA-NETO E | 2013 | PLoS One2013，8，79： | 1 |
| 8 | Clinical and laboratory evaluation of hospitalized patients with severe ovarian hyperstimulation syndrome显示文摘 | Sabino J Filho C Samama M | 2003 | Reproductive Biomedicine Online2003，6，： | 1 |
| 9 | Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord 显示文摘 | Honore P Luger N M Sabino M A C | 2000 | Nature Med2000，6，5： | 1 |
| 10 | Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand 显示文摘 | Feige U Sabino M A C | 1999 | Nature1999，402，6759： | 1 |
| 11 | Continuous Production of Inorganic Magnetic Nanocomposites for Biomedical Applications by Laser Pyrolysis显示文摘 | Sabino V V Yann L RocIo C | 2007 | Magnetism and Magnetic Materials2007，，311： | 1 |
| 12 | Method development for the quantitative determination of lactulose in heat treated milks by HPAEC with pulsed ampere metric detection显示文摘 | Tommaso R C Massimiliaao A Sabino A B | 1999 | Anal Chem1999，71，21： | 1 |
| 13 | Parabolic nondif- fracting optical wave fields 显示文摘 | MIGUEL A B JULIO C G V SABINO Ch C | 2004 | Optics Letters2004，29，1： | 1 |
| 14 | Deter- mination of diltiazem based on the reduction of Cu (Ⅱ)-BCA complexes in micellar medium显示文摘 | SABINO LARISSA Z L MARINO DANIELE C MOYA H D | 2010 | Canadian Journal of Chemistry2010，88，6： | 1 |
| 15 | Continuous production of inorganic magnetic nanocomposites for biomedical applications by laser pyrolysis显示文摘 | Sabino V V Yann L Rocio C | 2007 | Magnetism and Magnetic Materials2007，311，： | 1 |
| 16 | Management of acute respiratory distress syndrome in a French Bulldog using airway pressure release ventilation显示文摘 | Sabino C V Holowaychuk M Bateman S | 2013 | J Vet Emerg Crit Care (San Antonio)2013，23，4： | 1 |
| 17 | Obesity with No Metabolic Syndrome and Adipose Tissue Expansion Based Solely on Risk Factors and Inflammatory Marker of Coronary Heart Disease in Premenopausal Women 显示文摘 | Ramos S A Sabino A P Ferreira D C | 2012 | Archivos Lati- noamericanos De Nutricion2012，62，3： | 1 |
| 18 | Resolution of DL-hydantoins by D-hydantoinase from Vigna angularis: Production of highly enantioenriched N-carbamoyl-D-phenylglycine at 100% conversion 显示文摘 | Arcuri M B Antunes O A C Sabino S J Pinto G F Oestreicher E G | 2000 | Amino Acids2000，19，： | 1 |
| 19 | Precancerous colorectal lesions显示文摘 | Vincenza C Domenico S Sabino R | 2013 | Int J Oncol2013，43，4： | 1 |
| 20 | Inflammation and poor response to treatment with erythropoietin in chronic kidney disease显示文摘 | WV D O L SABINO A P FIGUEIREDO R C | 2015 | Minerva Stomatol2015，37，2： | 1 |
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