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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Portal vein thrombosis after splenectomy显示文摘 | Emily R Winslow L.Michael Brunt Jeffery A Drebin Nathaniel J Soper Mary E Klingensmith | 2002 | The American Journal of Surgery2002，，6： | 3 |
| 3 | Elucidating the spread of the emerging canid nematode Angiostrongylus vasorum between Palaearctic and Nearctic ecozones显示文摘 | Jefferies R Shaw SE Willesen J et 01 | 2010 | Infect Genet Evol2010，10，4： | 1 |
| 4 | Glycosylation of recombinant antibody therapeutics显示文摘 | JEFFERIS R | 2005 | Biotechnol Pro2005，21，1： | 1 |
| 5 | Transverse myelitis, retrospective analysis of 33 cases,with differentiation of cases associated with multiple sclerosis and parainfectious events显示文摘 | Jeffery D R Mandler R N Davis L E | 1993 | Arch Neurol1993，50，5： | 1 |
| 6 | Nonlinear micro local analysis of semi linear hyperbolic systems in one space dimension显示文摘 | Jeffery R Michael R | 1982 | Duke Math J1982，49，2： | 1 |
| 7 | Effect of heat shock or cold shock treatment on the resistance of lactococcus lactis to freezing and lyophilization显示文摘 | Jeffery R B Chan L | 1999 | Cryobiology1999，，39： | 1 |
| 8 | Antibody therapeutics:Isotype and glycoform selec- tion显示文摘 | JEFFERIS R | 2007 | Expert Opin Biol Ther2007，7，9： | 1 |
| 9 | Early versus late enteral nu- tritional support in adults with burn injury显示文摘 | Wasiak J Cleland H Jeffery R | 2007 | J Hum Nutr Diet2007，20，2： | 1 |
| 10 | The effect of novel polymorphisms in the interleukin-6 (IL-6)gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis显示文摘 | Fishman D Faulds G Jeffery R | 1998 | J Clin Invest1998，102，7： | 1 |
| 11 | Bone marrow-derived cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome显示文摘 | Prodromidi EI Poulsom R Jeffery R Roufosse CA Pollard PJ Pusey CD | 2006 | Stem Cells2006，24，11： | 1 |
| 12 | Cultivar responses to water stress in potato: effects of shoot and roots 显示文摘 | Jefferies R A | 1993 | New Phytologist1993，123，3： | 1 |
| 13 | Effect of heat Shock or cold shock treatment on the resistance of lactococcus lactis to freezing and lyophilization显示文摘 | Jeffery R Broadbent Chan Lin | | 0，，： | 1 |
| 14 | Corrosion protecting using-polyaniline coating formulations显示文摘 | Silvermau D C Jefferys C R | 1997 | Synthetic Metal1997，85，2： | 1 |
| 15 | Use of combination therapy with immunomodulators and immunosuppressants in treating multiple sclerosis显示文摘 | Douglas R Jeffery | 2004 | Neurology2004，63，126： | 1 |
| 16 | Corrosion protecting usingpolyaniline coating formulations显示文摘 | Kinlen P J Silverman D C Jefferys C R | 1997 | Synthetic Metal1997，85，2： | 1 |
| 17 | Convergence properties of the Nelder-Mead simplex method in low dimensions显示文摘 | Jeffery C L James A R Margaret H W | 1998 | Society for Industrial and Applied Mathematics1998，9，1： | 1 |
| 18 | The expression of E-cadherin and catenins in sporadic colorectal carcinoma显示文摘 | El-Bahrawy MA Poulsom R Jeffery R | | 0，，： | 1 |
| 19 | Biochar application does not improve the soil hydrological function of a sandy soil显示文摘 | Jeffery S Meinders M B J Stoof C R | 2015 | Geoderma2015，25，： | 1 |
| 20 | Three composite finishing systems: a multisite in vitro evalua- tion显示文摘 | Jefferies S R Barkmeier W W Gwinnett A J | 1992 | J Esthet Dent1992，4，6： | 1 |
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