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	题名	作者	年代	出处	被引量
1	Comparative analysis of the effectiveness of abiraterone before and after docetaxel in patients with metastatic castration-resistant prostate cancer显示文摘AIM: To study the efficacy and safety of abiraterone in patients with and without prior chemotherapy.METHODS: The databases including Pub Med and abstracts presented at the American Society of Clinical Oncology meetings up to April 2014 were systematically searched. Eligible studies included randomized controlled trials(RCTs) in which abiraterone plus prednisone was compared to placebo plus prednisone in metastatic castration-resistant prostate cancer(CRPC) patients. The summary incidence, relative risk, hazard ratio and 95%CI were calculated using random or fixed-effects models. Heterogeneity test was performed to test between-study differences in efficacy and toxicity.RESULTS: A total of two phase III RCTs were included in our analysis, with metastatic CPRC patients before(n = 1088) and after chemotherapy(n = 1195). Prior chemotherapy did not significantly alter the effect of abiraterone on overall survival(P = 0.92) and prostatespecific antigen(PSA) progression-free survival(P = 0.13), but reduced its effect on radiographic-prog-ression-free survival(P = 0.04), objective response rate(P < 0.001), and PSA response rate(P < 0.001). Prior chemotherapy significantly increased the specific risk of fluid retention and edema(P < 0.001) and hypokalemia(P < 0.001), but decreased the risk of all-grade hypertension(P < 0.001) attributable to abiraterone. There was no significant difference of cardiac disorders associated with abiraterone between the two settings(P = 0.58). CONCLUSION: Prior chemotherapy may reduce the effectiveness of abiraterone in patients with metastatic CRPC.	Raji Shameem Muhammad Saad Hamid Kevin Y Xu Shenhong Wu	2015	World Journal of Clinical Oncology2015，6，4：	3
2	Air pollution effects on the gut microbiota显示文摘	Saad Y Salim Gilaad G Kaplan Karen L Madsen	2014	Gut Microbes2014，，：	3
3	Dynamic thick restarting of the Davidson, and the implicitly restarted Arnoldi methods 显示文摘	Stathopoulos A Saad Y Wu K	1998	SIAM Journal on Scientific Computing1998，19，1：	1
4	Projection and deflation methods for partial pole assignment in linear state feedback 显示文摘	SAAD Y	1988	IEEE Trans Autom Control1988，33，：	1
5	Orthogonal neighborhood preser- ving projections:a projection-based dimensionality reduc- tion technique显示文摘	Kokiopoulou E Saad Y	2007	IEEE Transactions on Pattern Analysis and Machine Intelligence2007，29，12：	1
6	Gmres: a generalized mini- mal residual algorithm for solving nonsymmetric linear systems显示文摘	SAAD Y SCHULTZ M H	1986	SIAM Journal on Scientific and Statisti- cal Computing1986，7，：	1
7	Dense Subgraph Extraction with application to community detection显示文摘	Chen J Saad Y	2012	IEEE Transactions on Knowledge and Da- ta Engineering2012，24，：	1
8	The diagnosis of malignancy in effusion cytology:a pattern recognition approach显示文摘	Pereira TC Saad RS Liu Y	2006	Adv Anat Pathol2006，13，4：	1
9	Ischemic preconditioning of the liver in rats: implications of heat shock protein induction to increase tolerance of ischemiareperfusion in]ury显示文摘	Kume M Yamamoto Y Saad S	1996	J Lab Clin Med1996，128，3：	1
10	A Flexible Inner-Outer Methods Precondition GMRES Algorithm显示文摘	Saad Y	1993	SIAM J Sci Comput1993，14，2：	1
11	GMRES:a generalized minimal residual algorithm for solving nonsymmetric linear systems显示文摘	SAAD Y SCHULTZ H	1986	SIAM J Sci Statist Comput1986，7，3：	1
12	GMRES:a Generalized Minimal Residual Algorithm for Solving Non-symmetric Linear Systems显示文摘	Saad Y Schultz M	1986	S/AM Journal on Scientific and Statistical Computing1986，7，3：	1
13	Cardiotoxic effects of arsenic trioxide/inatinib mesilate combination in rats显示文摘	Saad S Y Alkharfy K M Arafah M M	2006	Journal of Pharmacy and Pharmacology2006，58，4：	1
14	Lymphatic vessel density as prognostic marker in esophageal ade- nocarcinoma显示文摘	SAAD R S LINDNER J L LIU Y	2009	Am J Clin Pathol2009，131，：	1
15	GMRES:a generalized minimal residual algorithm for solving nonsymmetric linear systems显示文摘	Saad Y Schultz M H	1986	Comput Appl Math1986，7，：	1
16	Krylov subspace methods for solving large unsymmetric linear systems显示文摘	Y Saad		0，，155：	1
17	Lymphatic microvessel density as prognostic marker in colorectal cancer显示文摘	SAAD R S KORDUNSKY L LIU Y L	2006	Mod Pathol2006，19，：	1
18	A Flexible Inner-outer Preconditioned GMRES Algorithm显示文摘	Saad Y	1993	SIAM Journal on Scientific Computing1993，14，2：	1
19	GMRES:A generalized minimal residual algorithm for solving non-symmetric linear systems显示文摘	Y Saad M H Schultz		0，，03：	1
20	Approximate inverse preconditioners via sparse-sparse iterations 显示文摘	CHOW E SAAD Y	1998	SIAM journal1998，，19：	1

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