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| 1 | CDX2 as a marker for intestinal differentiation: Its utility and limitations显示文摘CDX2 is a nuclear homeobox transcription factor that belongs to the caudalrelated family of CDX homeobox genes. The gene encoding CDX2 is a nonclustered hexapeptide located on chromosome 13q12-13. Homeobox genes play an essential role in the control of normal embryonic development. CDX2 is crucial for axial patterning of the alimentary tract during embryonic development and is involved in the processes of intestinal cell proliferation, differentiation, adhesion, and apoptosis. It is considered specif ic for enterocytes and has been used for the diagnosis of primary and metastatic colorectal adenocarcinoma. CDX2 expression has been reported to be organ specif ic and is normally expressed throughout embryonic and postnatal life within the nuclei of epithelial cells of the alimentary tract from the proximal duodenum to the distal rectum. In this review, the authors elaborate on the diagnostic utility of CDX2 in gastrointestinal tumors and other neoplasms with intestinal differentiation. Limitations with its use as the sole predictor of a gastrointestinal origin of metastatic carcinomas are also discussed. | Reda S Saad Zeina Ghorab Mahmoud A Khalifa | 2011 | World Journal of Gastrointestinal Surgery2011，3，11： | 11 |
| 2 | Value of carcinoembryonic antigen and cytokeratins for the detection of recurrent disease following curative resection of colorectal cancer显示文摘瞄准:与颜色在病人为周期性的疾病的察觉评估 carcinoembryonic 抗原(CEA ) 和 cytokeratins 的手术后的连续试金的功效在激进的外科以后的表面的腺癌。方法:在 1993 和 2000 之间,有颜色的 120 个病人表面的腺癌在外科的肠胃病学的部门经历了激进的外科, Sao Paulo-Escola Paulista de Medicina 的联邦大学, Sao Paulo,巴西。周期的手术后的评估被 assaying 标记在外部浆液,结肠镜检查和成像检查执行。CEA 的存在与 72 U/L 阀值用 LIA 地席 TPA-M Prolifigen 方法与 5 microg/L 阀值,和 cytokeratins 用 Delfia 方法被检测。结果:在第一手术后的年里,没有周期性的疾病的病人有 CEA 的正常层次( 1.5 +/- 0.9 microg/L )并且单音的同种细胞的织物多肽 antigen-M ( TPA-M , 64.4 +/- 47.8 U/L ),当有复发的病人有 CEA 的高水平时( 6.9 +/- 9.8 microg/L , P <
0.01 )并且 TPA-M ( 192.2 +/- 328.8 U/L , P <
0.05 )。在第二手术后的年期间,没有肿瘤复发的病人有 CEA 的正常层次( 2.0 +/- 1.8 microg/L )并且 TPA-M ( 50.8 +/- 38.4 U/L ),当有复发的病人有 CEA 的高水平时( 66.3 +/- 130.8 microg/L , P <
0.01 )并且 TPA-M ( 442.7 +/- 652.8 U/L , P <
0.05 )。吝啬的后续时间是 22.3 瞬间。在 23 种情况中有复发。没有完成激进的切除,五个手术被动。在肿瘤标记层次的上升先于复发的鉴定:在七的 CEA (30%) 和在十一个个人(48%) 的 TPA-M。结论:由 CEA 和 cytokeratins 的连续试金的集中的后续允许颜色的早察觉表面的瘤复发。 | Luís C Fernandes Su B Kim Sarhan S Saad Delcio Matos | 2006 | World Journal of Gastroenterology2006，12，24： | 3 |
| 3 | Mesuaferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways显示文摘Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction(SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active α-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods. α-amyrin and betulinic acid contents of SF-3 were measured by HPLC methods. Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells. In addition, increased levels of caspases-9 and-3/7 levels were also observed in SF-3 treated cells. SF-3 showed promising antimetastatic properties in multiple in vitro assays. Multi-pathway analysis revealed significant down-regulation of WNT, HIF-1α, and EGFR with simultaneous up-regulation of p53, Myc/Max, and TGF-β signalling pathways in SF-3 treated cells. In addition, promising growth inhibitory effects were observed in SF-3 treated HCT 116 tumour spheroids, which give a hint about in vivo antitumor efficacy of SF-3 phytoconstituents. In conclusion, these results demonstrated that anticancer effects of SF-3 towards colon cancer are through modulation of multiple molecular pathways. | Muhammad Asif Armaghan Shafaei Aman Shah Abdul Majid Mohammed Oday Ezzat Saad S Dahham Mohamed B.Khadeer Ahamed Chern Ein Oon Amin Malik Shah Abdul Majid | 2017 | Chinese Journal of Natural Medicines2017，15，7： | 2 |
| 4 | Protective effect of heat shock pretreatment with heat shock protein induction before hepatic warm ischemia injury caused by pringle maneuver 显示文摘 | 8,Saad S Kanai M Awane M | 1995 | Surgery1995，118，3： | 1 |
| 5 | Effect of temperature on physical and mechanical properties of concrete containing silica fume显示文摘 | Saad M Abo-EI-Enein S A | 1996 | Cement and Concrete Research1996，26，5： | 1 |
| 6 | A SiC14-ZnC12 induced general, mild and efficient one-pot, three- component synthesis of fl-amido ketone libraries 显示文摘 | Tarek A Salama Saad S Elmorsy Abdel-Galel M Khalil | 2007 | Tetrahedmn Letters2007，48，： | 1 |
| 7 | Phragmalin limonoids from Chukrasia tabularis 显示文摘 | NAKATANI M ABDELGALEIL S A M SAAD M M G | 2004 | Phytochemistry2004，65，20： | 1 |
| 8 | High glucose-mediated effects on endothelial cell proliferation occur via p38 MAP kinase显示文摘 | McGinn S Saad S Poronnik P | 2003 | Am J Physiol Endocrinol Metab2003，285，4： | 1 |
| 9 | A laboratory study of rock acoustic characteristics by parametric spectral estimation显示文摘 | Saad S Herous L Doghmane N | 2013 | Acta Geodaetica et Geophys- ica Hungarica2013，34，12： | 1 |
| 10 | Proliferative activity of human thy- roid cells in various age groups and its correlation with the risk of thyroid cancer after radiation exposure 显示文摘 | Saad AG Kumar S Ron E | 2006 | J Clin Endocrinol Metab2006，91，7： | 1 |
| 11 | Pediocin N5p from Pediococcus pentosaceus:adsorption on bacterial strains 显示文摘 | de Nadra M C M de Lamelas D S de Saad A M S | 1998 | International Journal of Food Microbiology1998，39，： | 1 |
| 12 | Contribution of different sources to the pollution of wet weather flows in com- bined sewers 显示文摘 | GROMAIRE M C GARNAUD S SAAD M | 2001 | Water Research2001，35，2： | 1 |
| 13 | Ischemic preconditioning of the liver in rats: implications of heat shock protein induction to increase tolerance of ischemiareperfusion in]ury显示文摘 | Kume M Yamamoto Y Saad S | 1996 | J Lab Clin Med1996，128，3： | 1 |
| 14 | Expression of alpha-hemoglobin stabilizing protein gene during human erythropoiesis显示文摘 | DOS SANTOS C O DUARTE A S SAAD S T | 2004 | Exp Hematol2004，32，2： | 1 |
| 15 | Balloon-occluded retrograde trans- venous obliteration of gastric varices : conception, evolution, and history 显示文摘 | Saad WE Khaja MS Hirota S | 2012 | Tech Vasc Interv Radio12012，15，3： | 1 |
| 16 | Linear mixed-effects modeling approach to FMRI group analysis显示文摘 | Chen G Saad Z S Britton J C | 2013 | Neurolmage2013，73，： | 1 |
| 17 | Polyethylene glycol 4000 attenuates adhesion formation in rats by suppression of peritoneal inflammation and collagen incorporation显示文摘 | Nagelschmidt M Minor T Saad S | 1998 | Am J Surg1998，176，： | 1 |
| 18 | Depression during pregnancy: Causes, risk factors and treatment显示文摘 | Khan M O Saad S M A | 2010 | J Pak Med Assoc2010，60，1： | 1 |
| 19 | Establishment of long- term embryogenic cultures of seedless Vitis vinifera cuhivars - a synergistic effect of auxins and the role of abscisic acid显示文摘 | PERL A SAAD S SAHAR N HOLLAND D | 1995 | Plant Science1995，104，： | 1 |
| 20 | Multiple adult xanthogranuloma: case report and literature review显示文摘 | Saad N Skowron F Dalle S | 2006 | Dermatology2006，212，1： | 1 |
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