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| 1 | Pharmacogenomics in colorectal cancer: The first step for individualized-therapy显示文摘Interindividual differences in the toxicity and response to anticancer therapies are currently observed in practically all available treatment regimens. A goal of cancer therapy is to predict patient response and toxicity to drugs in order to facilitate the individualization of patient treatment. Identification of subgroups of patients that differ in their prognosis and response to treatment could help to identify the best available drug therapy according the genetic profile. Several mechanisms have been suggested to contribute to chemo-therapeutic drug resistance: amplification or overexpression of membrane transporters, changes in cellular proteins involved in detoxification or in DNA repair, apoptosis and activation of oncogenes or tumor suppressor genes. Colorectal cancer (CRC) is regarded as intrinsically resistant to chemotherapy. Several molecular markers predictive of CRC therapy have been included during the last decade but their results in different studies complicate their application in practical clinical. The simultaneous testing of multiple markers predictive of response could help to identify more accurately the true role of these polymorphisms in CRC therapy. This review analyzes the role of genetic variants in genes involved in the action mechanisms of the drugs used at present in colorectal cancer. | Eva Bandrés Ruth Zárate Natalia Ramirez Ana Abajo Nerea Bitarte Jesus García-Foncillas | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 2 | Moving forward in colorectal cancer research, what proteomics has to tell显示文摘Colorectal cancer is the third most common cancer and is highly fatal. During the last several years, research has been primarily based on the study of expression profiles using microarray technology. But now, investigators are putting into practice proteomic analyses of cancer tissues and cells to identify new diagnostic or therapeutic biomarkers for this cancer. Because the proteome reflects the state of a cell, tissue or organism more accurately, much is expected from proteomics to yield better tumor markers for disease diagnosis and therapy monitoring. This review summarizes the most relevant applications of proteomics the biomarker discovery for colorectal cancer. | Nerea Bitarte Eva Bandrés Ruth Zárate Natalia Ramirez Jesus Garcia-Foncillas | 2007 | World Journal of Gastroenterology2007，13，44： | 3 |
| 3 | Diagnosis of renal vascular disease with MR angiography显示文摘 | QIAN D O N G STEFAN O S Ruth C C | 1999 | Radiographics1999，19，6： | 2 |
| 4 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 5 | A new family of mesoporous molecular sieves prepared with liquid crystal templates 显示文摘 | Beck J S Vartuli J C Ruth W J | 1992 | Journal of American Chemical Society1992，114，10： | 1 |
| 6 | Tumor necrosis factor-alpha expression in tumour islets confers a surival advantage in non-small cell lung cancer显示文摘 | Chandra MO Arti S Ruth HG | 2010 | BMC Cancer2010，10，： | 1 |
| 7 | Human Papillomavirus (HPV) DNA Copy Number Is Dependent on Grade of Cervical Disease and HPV Type显示文摘 | David C S Ruth A T Guillermo T L | 1999 | Clin Microbiol1999，37，： | 1 |
| 8 | The influence of wood flour particle size and content on the rheological, physical, mechanical and morphological properties of EVA/wood cellular composites显示文摘 | Matheus V.G. Zimmermann Taís C. Turella Ruth M.C. Santana Ademir J. Zattera | 2014 | Materials and Design2014，，： | 1 |
| 9 | Influence of 13-1acto- globulin, pH and presence of other aroma compounds on the air/liquid partition coefficients of 20 aroma compounds varying in functional group and chain length 显示文摘 | VAN RUTH S M VILLENEUVE E | 2002 | Food Chemistry2002，79，2： | 1 |
| 10 | Pseudomyxoma peritonei : a review of 62 cases 显示文摘 | Van Ruth S Acherman YIZ Van de Vijver MJ | 2003 | Eur J Surg Oncol2003，29，8： | 1 |
| 11 | Wound management with vacuum-assisted closure:experience in 51 pediatric patients显示文摘 | CANIANO D A RUTH B TEICH S | 2005 | J Pediatr Surg2005，40，1： | 1 |
| 12 | Gas chromatography/snitIing port analysis and sensory evaluation of commercially dried bell peppers(Capsicum annuum) after rehydration显示文摘 | Van Ruth S M Roozen J P | 1994 | Food Chemistry1994，51，： | 1 |
| 13 | Role of macrophage inflammatoryprotein-3alpha and its ligand CCR6 in rheumatoid arthritis显示文摘 | Ruth JH Shahrara S Park CC | | 0，，： | 1 |
| 14 | A new family of mesoporous molecular sieves prepared with liquid crystal templates显示文摘 | Beck J S Vartuli J C Ruth W J | 1992 | J Am Chem Soc1992，114，10： | 1 |
| 15 | Laboratory aging methods for simulation of field aging of asphalts 显示文摘 | HUANG S C MANG T RUTH B E | 1996 | Journal of Materials in Civil Engineering1996，8，3： | 1 |
| 16 | An Overview of Analytical Methods for Determining the Geographical Origin of Food Products 显示文摘 | LUYKX D M RUTH S M | 2008 | Food Chemistry2008，107，2： | 1 |
| 17 | Evaluation of three gas chromatography and two direct mass spectrometry techniques for aroma analysis of dried red bell peppers 显示文摘 | Van Ruth S Boscaini E Mayr D | 2003 | International Journal of Mass Spectrometry2003，，： | 1 |
| 18 | Role of su- peroxide dismutases (SODs) in controlling oxidative stress in plants 显示文摘 | RUTH G A NEVAL E LENWOOD S H | 2002 | Journal of Experimental Botany2002，53，： | 1 |
| 19 | Gas chromatograpby-olfactometry (GC-O) and proton transfer reaction-mass spectrometry (PTR-MS) analysis of the flavor profile of Grana Padano,Parmigiano Reggiano,and Grana Trentino cheeses显示文摘 | BOSCAINI E VAN RUTH S BIASIOLI G | 2003 | J Asric Food Chem2003，，51： | 1 |
| 20 | An optimal algorithm for approximate nearest neighbor searching in fixed dimensions 显示文摘 | Sunil Arya David M Mount Nathan S Netanyahu Ruth Silverman Angela Y Wu | 1998 | Journal of the ACM1998，45，6： | 1 |
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