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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Anticoagulant modulation of inflammation in severe sepsis显示文摘Inflammation and coagulation are so tightly linked that the cytokine storm which accompanies the development of sepsis initiates thrombin activation and the development of an intravascular coagulopathy. This review examines the interaction between the inflammatory and coagulation cascades, as well as the role of endogenous anticoagulants in regulating this interaction and dampening the activity of both pathways. Clinical trials attempting to improve outcomes in patients with severe sepsis by inhibiting thrombin generation with heparin and or endogenous anticoagulants are reviewed. In general, these trials have failed to demonstrate that anticoagulant therapy is associated with improvement in mortality or morbidity. While it is possible that selective patients who are severelyill with a high expected mortality may be shown to benefit from such therapy, at the present time none of these anticoagulants are neither approved nor can they be recommended for the treatment of sepsis. | Karen S Allen Eva Sawheny Gary T Kinasewitz | 2015 | World Journal of Critical Care Medicine2015，4，2： | 14 |
| 3 | 滋养细胞组织 GATA-3表达:445例免疫组化及其诊断应用分析显示文摘GATA-3主要表达在乳腺癌和尿路上皮癌,而在正常或病变滋养细胞组织中的表达报道甚少。作者选取445例正常/病变滋养细胞组织及其肿瘤进行 GATA-3免疫组化评估,根据着色强弱标记为(-~-),探讨GATA-3在下列组织中的表达意义。这些组织包括孕囊/中晚期妊娠胎盘/异位妊娠、葡萄胎、胎盘结节、正常/异常植入部位、绒毛膜癌、上皮样滋养细胞肿瘤、胎盘滋养细胞肿瘤、非典型平滑肌瘤(含平滑肌肉瘤)、子宫颈和肺的鳞状细胞癌。 | Natalie B Allen M G Ie-Ming S 许文静 余英豪 | 2015 | 临床与实验病理学杂志2015，31，9： | 11 |
| 4 | 杂环联苯型聚芳醚酮热稳定性研究显示文摘用热重分析法详细研究了自制杂环联苯型聚芳醚酮(MPEK)的热稳定性及热分解机理。采用Ozawa方法计算出了其热降解活化能,提出了其在空气和N_2中的分解机理,这对此新型聚芳醚酮的加工和推广应用具有重要的指导意义。 | 孟跃中 蹇锡高 徐艳 曲敏杰 Allen S Hay | 1994 | 高分子材料科学与工程1994，10，6： | 9 |
| 5 | 豚鼠外源性血管内皮细胞生长因子增强内耳屏障转运作用的磁共振成像研究显示文摘目的观察血管内皮细胞生长因子(vascularendothelialgrowthfactor, VEGF)能否改变血迷路屏障和血外淋巴屏障的物质转运作用。方法11只300 ~900g雌雄兼并的杂色豚鼠在甲苯噻嗪(16mg/kg)和氯氨酮(60mg/kg)基础麻醉下接受手术,通过圆窗膜(明胶海绵吸附)将VEGF(6耳)或磷酸盐缓冲液(PBS, 5耳)投放至内耳。用T1对比剂二乙烯三胺五乙酸双甲酰胺钆(gadolinium diethylenetriamine pentaacetate bismethylamide, Gd DTPA BMA)作为内耳屏障转运示踪剂,用4 7T场强, 40cm孔径的BrukerBiospecAvance47 /40试验磁共振系统进行豚鼠耳蜗二维磁共振成像观测,用Paravision软件进行图像密度分析,用AdobePhotoshop6 0软件进行图像呈示。结果圆窗膜投放PBS未影响血外淋巴屏障渗透性变化。圆窗膜投放VEGF可显著增强处理侧血外淋巴屏障渗透性,VEGF处理的耳蜗鼓阶内Gd DTPA BMA转运显著增加(P<0 01 ), VEGF处理的耳蜗前庭阶内Gd DTPA BMA转运也显著增加(P<0 01)。VEGF处理的耳蜗中阶内Gd DTPA BMA转运无明显增加(P>0 05)。结论VEGF显著增强血外淋巴屏障的物质转运作用并可能有利于内耳在各种有害环境下的代偿及修复。 | 邹静 Pyykko Ilmari Bjelke Borje Counter S Allen | 2005 | 中华耳鼻咽喉头颈外科杂志2005，40，4： | 3 |
| 6 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 7 | Measurements of transpiration from savannah shrubs using sap flow gauges显示文摘 | ALLEN S J GRIME V L | 1995 | Agri and For Meter1995，75，： | 2 |
| 8 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 9 | Interrelation of spectroscopic properties with the thermal and photochemical behavior of titanium dioxide pigments in metallocene polyethylene and alkyd based paint films: micron versus nanoparticles 显示文摘 | Allen N S Edge M Samdoval G | 2002 | Polymer Degradation and Stability2002，，76： | 1 |
| 10 | Pharmacokinetics and tolerability of gemifloxacin (SB- 265805) after administration of single oral doses to healthy volunteers 显示文摘 | Allen A Bygate E Oliver S | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 11 | Measurement and estimation of evaporation from soil under sparse barley crops in northem Syria显示文摘 | Allen S J | 1990 | Agric Forest Meteorol1990，49，4： | 1 |
| 12 | Asymptotic profile of thesteady states for an SIS epidemic patch model显示文摘 | Allen L J S Bolker B M Lou Y Nevai A L | 2007 | SIAM J Appl Math2007，，67： | 1 |
| 13 | The localization of target antigens and autoantibodies in linear IgA disease is variable; correlation of immunogold electron microscopy and immunoblotting显示文摘 | Zhou S Ferguson DJ Allen J | 1998 | Br J Dermatol1998，139，： | 1 |
| 14 | Porter's generic strategies:An exploratory study of their use in JAPAN显示文摘 | Allen R S Helms M M Takeda M B | 2007 | Journal of Business Strategies2007，24，1： | 1 |
| 15 | Nonlinear shear instabilities of alongshore currents over barred beaches 显示文摘 | Slinn D N Allen J S Newberger P A | 1998 | Journal of Geophysical Research1998，103，18： | 1 |
| 16 | 4 THZ Sidewall-Etched Varactors for Sub-Mm-Wave Sampling Circuits显示文摘 | Allen S T Bhattacharya U Rodwell M J W | 1993 | IEEE1993，，： | 1 |
| 17 | Red imported fire ant impacts on northern bobwhite populations显示文摘 | Allen C R Lutz R S Demarais S | 1995 | Ecol Appl1995，，3： | 1 |
| 18 | Prediagnostic symptom recognition and help seeking among cancer patients 显示文摘 | Mor V Masterson - Allen S Goldberg R | 1990 | J Community Health1990，15，4： | 1 |
| 19 | Hollow metal microneedles for insulin delivery to diabetic rats 显示文摘 | Davis S P Martanto W Allen M G | 2005 | IEEE Transactions on Biomedical Engineering2005，52，5： | 1 |
| 20 | Effect of 2,6 - di- chloroisonicotinic acid or benzothiadiazole on Alternaria leaf spot, bacterial blight and VerticiUium wilt in cotton under field conditions 显示文摘 | Colson - Hanks E S Allen S J Deverall B J | 2000 | Australasian Plant Pathology2000，29，3： | 1 |
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