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| 1 | High Expression of NKG2A/CD94 and Low Expression of Granzyme B Are Associated with Reduced Cord Blood NK Cell Activity显示文摘Human umbilical cord blood (CB) has recently been used as a source of stem cells in transplantation. NK cells derived from CB are the key effector cells involved in graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL). It was reported that the activity of CB NK cells was lower than that of adult peripheral blood (PB) NK cells. In this study,we analyzed the expression of some NK cell receptors and cytotoxicity-related molecules in CB and PB NK cells. The expressions of activating NK receptors,CD16,NKG2D and NKp46,did not show significant difference between CB and PB NK cells. But the expression of inhibitory receptor NKG2A/CD94 was significantly higher on CB NK cells. As to the effector function molecules,granzyme B was expressed significantly lower in CB NK cells,but the expressions of intracellular perforin,IFN-γ,TNF-α and cell surface FasL and TRAIL did not show difference between CB and PB NK cells. The results indicated that the high expression of NKG2A/CD94 and low expression of granzyme B may be related with the reduced activity of CB NK cells. | Yanyan Wang1,2,Han Xu1,2,Xiaodong Zheng1,Haiming Wei1,Rui Sun1 and Zhigang Tian1,31Institute of Immunology,Hefei National Laboratory for Physical Materials at Microscale and School of Life Sciences,University of Science and Technology of China,Hefei 230027,China 2Yanyan Wang and Han Xu equally contributed to the present study | 2007 | Cellular & Molecular Immunology2007，4，5： | 5 |
| 2 | Diagnostic ac- curacy of staging laparoscopy for detecting metastasized or locally advanced perihilar eholangioearcinoma: a sys- tematic review and meta-analysis显示文摘 | Coelen ILl Ruys AT Besselink MG | 2016 | Surg Endose2016，0219，： | 1 |
| 3 | Radiological staging in patients with hilar cholangiocarcinoma: a systematic re- view and meta-analysis显示文摘 | Ruys AT Van Beem BE Engelbrecht MR | 2012 | Br J Radiol2012，85，1017： | 1 |
| 4 | Source and variation of carbonaceous aerosols at Mount Tai, North China: Results from a semi-continuous instrument 显示文摘 | Wang Zhe Wang Tao Gao Rui et at | 2009 | Atmospheric Environment2009，45，： | 1 |
| 5 | Effects of baffle inclination angle on flow and heat transfer of a heat exchanger with helical baffles显示文摘 | LEI Yonggang HE Yaling LI Rui et at | 2008 | Chemical Engineering and Processing: Process Intensification2008，47，12： | 1 |
| 6 | Radiological staging in patients with hilar cholangiocarcinoma: a systematic re- view and meta-analysis显示文摘 | Ruys AT van Beem BE Engelbrecht MR | 2012 | Br J Radiol2012，85，1017： | 1 |
| 7 | Radiological staging in patients with hilar cholangiocarcinoma 显示文摘 | Ruys AT van Beem BE Engelbreeht MR | 2012 | Br J Radiol2012，85，： | 1 |
| 8 | Surgical treatment of renal cell cancer liver metastases: a population-based study 显示文摘 | Ruys AT Tanis PJ Nagtegaal ID | 2011 | Ann Surg Oncol2011，18，7： | 1 |
| 9 | Surgical treatment of renal cell cancer liver metastases: a population-based study显示文摘 | Ruys AT Tanis PJ Nagtegaal ID | 2011 | Ann Surg Oncol2011，18，7： | 1 |
| 10 | Antiinflammatory effect of Forsythia suspensa Vahl and its active fraction显示文摘 | Ozaki Y Rui J Tang Y at al | 1997 | Bid Pharm Bull1997，20，8： | 1 |
| 11 | Unltorm and high-yield carbon nanotubes with modulated nitrogen concentration for promising nanoscale energetic materials显示文摘 | Liu Hao Zhang Yong Li Ruying et at | 2010 | International Journal of Energetic Materials and Chemical Propulsion2010，9，1： | 1 |
| 12 | Surgical treatment of renal cell can- cer liver metastases : A population - based study 显示文摘 | Ruys AT Tanis PJ Iris ND | 2011 | Ann Surg Oncol2011，18，7： | 1 |
| 13 | Extent of liver resec-tion for hilar cholangiocarcinoma ( Klatskin tumor) : how much isenough显示文摘 | van Gulik TM Ruys AT Busch OR | 2011 | Dig Surg2011，28，2： | 1 |
| 14 | Radiological stag- ing in patients with hilar cholangiocarcinoma: a systematic review and meta-analysis 显示文摘 | Ruys AT van Beem BE Engelbrecht MR | 2012 | Br J Radiol2012，85，1017： | 1 |
| 15 | Effects of pro-longed pneumoperitoneum on hepatic perfusion duringlaparoscopy显示文摘 | Hoekstra LT Ruys AT Milstein DM | 2013 | Ann Surg2013，257，2： | 1 |
| 16 | Staging laparoscopy for hilar cholangiocarcinoma: is it still worthwhile显示文摘 | RUYS AT BUSCH OR GOUMA DJ | 2012 | Indian J Surg Oncol2012，3，2： | 1 |
| 17 | Multidisciplinary management of hilar cholangiocaroma(Klatskin tumor):Extended resection is associated with improved survival显示文摘 | van Gulik TM Kloek JJ Ruys AT | 2011 | J Cancer2011，37，1： | 1 |
| 18 | Long-term survival in hilar cholangiocarcinoma also possible in unresectable patients显示文摘 | Ruys AT van Haelst S Busch OR | 2012 | World J Surg2012，36，9： | 1 |
| 19 | Radiological staging in patients with hilar cholangiocarcinoma: a systemat- ic review and meta-analysis 显示文摘 | Ruys AT van Beem BE Engelbrecht MR | 2012 | Br J Radiol2012，85，1017： | 1 |
| 20 | Extent of liver resection for hilar cholangiocarcinoma(klatskin tumor):how much is enough?显示文摘 | van Gulik TM Ruys AT Busch OR | 2011 | Dig Surg2011，28，2： | 1 |
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