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| 1 | WONCA研究论文摘要汇编——初级医疗中普里西特治疗模式对2型糖尿病患者的干预效果:整群随机对照试验显示文摘背景性功能障碍在2型糖尿病患者中较为普遍,也是糖尿病护理中最易被忽视的并发症之一。患者和医务工作者在糖尿病护理中对讨论性问题感到困难。普里西特治疗(PLISSIT)模式中的性咨询模型可能是有效工具,可以帮助医务工作者与2型糖尿病患者对性问题进行探讨。PLISSIT的含义是许可(Permission)、有限信息(Limited Information)、特别建议(Specific Suggestions)和强化治疗(Intensive Therapy)。尽管在糖尿病护理中经常建议使用PLISSIT模式,但是并没有证据证明其对2型糖尿病患者的有效性。本研究采用整群随机对照试验,评估PLISSIT模式在初级医疗中对2型糖尿病患者的干预效果。方法 /设计招募年龄40~75岁、表示对性功能不满意且愿意与全科医生讨论性问题的2型糖尿病患者。护士向所有参与者发放相关知识传单。干预组中,每例患者依据PLISSIT模式对全科医生进行性问题咨询;认为知识传单信息不足的患者可以预约全科医生进行常规护理。主要结局指标包括性功能、性功能满意度和生活质量;次要结局指标包括抑郁症状、性痛苦、情绪安康、治疗满意度。在研究开始前及研究3、12个月后,通过自我报告问卷对结局指标进行评估。通过电话采访对治疗满意度进行评估。讨论本研究介绍了整群随机对照试验的设计,对初级护理中使用PLISSIT模式对2型糖尿病患者干预的有效性进行研究。针对男性和女性2型糖尿病患者重要指标结果,提出了关于PLISSIT模式有效性的重要和缺失观点。 | Rutte A van Oppen P Nijpels G | 2015 | 中国全科医学2015，18，20： | 5 |
| 2 | Anti-adipogenic effect of flavonoids from Chromolaena odorata leaves in 3T3-L1 adipocytes显示文摘Objective: The leaves of Chromolaena odorata, a highly invasive shrub found growing wild worldwide, are traditionally used for wound healing. Due to its high flavonoid contents, we aimed to find a new application for this plant. Preliminary tests using its ethanolic leaf extract showed that it could suppress the accumulation of lipids in adipocytes. We therefore studied the anti-adipogenic effect of several C. odorata leaf extracts and the relationship between molecular structure and bio-activity of its isolated flavonoid constituents using 3 T3-L1 preadipocytes/adipocytes as a model.Methods: Three leaf extracts and thirteen flavonoids isolated from C. odorata were tested for their effect on lipid accumulation in 3 T3-L1 adipocytes using AdipoRed reagent, with quercetin as the positive control. The effects of active flavonoids on the adipocytes were confirmed by oil red 0 staining and visualized under a light microscope.Results: n-Hexane and ethyl acetate extracts of C. odorata leaves displayed anti-adipogenic activity. The latter extract was the more potent one, especially at 40 μg/ml. Four flavonoids, pectolinarigenin, kaempferide, 4,2'-dihydroxy-4',5',6'-trimethoxychalcone and dillenetin, exhibited significant, concentrationdependent inhibitory effects on lipid accumulation in 3 T3-L1 adipocytes. The most potent flavonoid obtained in this study was 4,2'-dihydroxy-4',5',6'-trimethoxychalcone, which caused 75% and 90% inhibition of cellular lipid accumulation at 30 and 50 μmol/L, respectively. Both kaempferide and 4,2'-dihy droxy-4',5',6'-trimethoxychalcone were major constituents in the ethyl acetate extract of this plant.Conclusion: C. odorata leaves contained several flavonoids with anti-adipogenic effects against lipid accumulation in 3 T3-L1 adipocytes. The plant, normally considered a useless weed, may actually provide an abundant source of biologically active flavonoids. | Supakanya Kumkarnjana Rutt Suttisri Ubonthip Nimmannit Thongchai Koobkokkruad Chutichot Pattamadilok Nontima Vardhanabhuti | 2018 | Journal of Integrative Medicine2018，16，6： | 2 |
| 3 | Physiological Effects of a Weight Loss Regimen Practiced by College Wrestlers显示文摘 | WEBSTER S RUTT R WELTMAN A | 1990 | Med Sci Sports Exe1990，22，2： | 1 |
| 4 | NUT midline carcinomamimicking tonsillitis in an eight-year-old girl 显示文摘 | Rutt A L Poulik J Siddiqui A H ef al | 2011 | Ann Otol RhinolLaryngol2011，120，8： | 1 |
| 5 | Physiological effects of a weight loss regimen practiced by college wrestlers显示文摘 | Webster S Rutt R Weltman A | 1990 | Med Sci Sports Exerc1990，22，2： | 1 |
| 6 | Examining the relationships among built environment, physical activity, and body mass index in E1 Paso, TX显示文摘 | Rutt CD Coleman KJ | 2005 | Prey Med2005，40，： | 1 |
| 7 | Constrained length minimum inductance gradient coil design 显示文摘 | Chronik BA Rutt BK | 1998 | Magnetic Resonance in Medicine1998，39，2： | 1 |
| 8 | Personality and Team Performance : A Meta - Analysis 显示文摘 | Miranda A G Peeters Harrie F J M Vantuijl Christel G Rutte Isabelle M M J Reymen | 2006 | European Journal of Personality2006，，20： | 1 |
| 9 | Team self-regulation and meeting deadlines in project teams : Antecedents and effects of temporal consensus 显示文摘 | GEVERS J M P VAN EERDE W RUTTE C G | 2009 | European Journal of Work and Organizational Psychology2009，18，3： | 1 |
| 10 | Efficacy of Thai medicinal plant extracts against herpes simplex virus type 1 infection in vitro and in vivo显示文摘 | Vimolmas Lipipun Masahiko Kurokawa Rutt Suttisri Pagorn Taweechotipatr Pornpen Pramyothin Masao Hattori Kimiyasu Shiraki | 2003 | Antiviral Research2003，，3： | 1 |
| 11 | Planning Behavior and Perceived Control of Time at Work显示文摘 | Claessens B J C van Eerde W Rutte C G Roe R A | | 0，，25： | 1 |
| 12 | Nutrient deficiencies before and after sleeve gastrectomy显示文摘 | van Rutte PW Aarts EO Smulders JF | 2014 | Obes Surg2014，24，10： | 1 |
| 13 | Projection presaturation: a fast and accurate technique for multidimensional spatial localization显示文摘 | Singh S Rutt BK Henkelman RM | 1990 | Journal of Magnetic Resonance1990，87，： | 1 |
| 14 | Syndromes attributed to 'minimal brain dysfunction' in childhood显示文摘 | Rutte M | 1982 | Am J Psychiatry1982，13，： | 1 |
| 15 | Meeting Deadlines in Work Groups: Implicit and Explicit Mechanisms显示文摘 | GEVERS J M P RUTTE C G VAN EERDE W | 2006 | Applied Psy- chology2006，55，1： | 1 |
| 16 | Psychological sequelae of brain damage in children显示文摘 | Rutte M | 1981 | Am J Psychiatry1981，138，： | 1 |
| 17 | Plant - derived' triterpenoid sweettness inhibitors显示文摘 | Rutt Suttisri IK- Soo Lee A Douglas Kinghorn | | 0，，： | 1 |
| 18 | Ovulation in adult rats after treatment with pregnant mare serum gonadotrophin during oestrus显示文摘 | Welschell R Rutte M | 1971 | Acta Endocrinol1971，68，： | 1 |
| 19 | Physiological effects of a weight loss regimen practiced by college wrestlers显示文摘 | WEBSTER S RUTT R WELTMAN A | 1990 | Med Sci Sport Exe1990，22，2： | 1 |
| 20 | Meeting deadlines in work groups: Implicit and explicit mechanisms显示文摘 | Gevers J M P Rutte C G and Van Eerde W | 2006 | Applied Psycho- logy:An International Review2006，55，1： | 1 |
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