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| 1 | Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity显示文摘Mesalazine is a 5-aminosalicylic acid derivative that has been widely used to treat patients with inflammatory bowel disease. Accumulating evidence indicates that mesalazine has a very low rate of adverse drug reactions and is well tolerated by patients. However, a few cases of pulmonary and cardiac disease related to mesalazine have been reported in the past, though infrequently, preventing clinicians from diagnosing the conditions early. We describe the case of a 32-yearold man with ulcerative colitis who was admitted with a two-month history of persistent fever following mesalazine treatment initiated 14 mo earlier. At the time of admission, mesalazine dose was increased from 1.5 to 3.0 g/d, and antibiotic therapy was started with no improvement. Three weeks after admission, the patient developed dyspnea, non-productive cough, and chest pain. Severe eosinophilia was detected in laboratory tests, and a computed tomography scan revealed interstitial infiltrates in both lungs, as well as a large pericardial effusion. The bronchoalveolar lavage reported a CD4/CD8 ratio of 0.5, and an increased eosinophil count. Transbronchial biopsy examination showed a severe eosinophilic infiltrate of the lung tissue. Mesalazine-induced cardiopulmonary hypersensitivity was suspected after excluding other possible etiologies. Consequently, mesalazine treatment was suspended, and corticosteroid therapy was initiated, resulting in resolution of symptoms and radiologic abnormalities. We conclude that mesalazine-induced pulmonary and cardiac hypersensitivity should always be considered in the differential diagnosis of unexplained cardiopulmonary symptoms and radiographic abnormalities in patients with inflammatory bowel disease. | José Ferrusquía Isabel Pérez-Martínez Ricardo Gómez de la Torre María Luisa Fernández-Almira Ruth de Francisco Luis Rodrigo Sabino Riestra | 2015 | World Journal of Gastroenterology2015，21，13： | 5 |
| 2 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 3 | UV/TiO_2 and UV/TiO_2-film for Degradation of Textile Dyes显示文摘This research focused on the feasibility and treatment efficiency of Advance Oxidation Process(AOP)-UV/TiO2 for three different kinds of simulated dye wastewater(FBL,FBB and S-RL).The first part of this study investigated the treatment of simulated dye wastewater with UV/TiO2 by changing TiO2 dosages,TiO2 particle sizes and dye concentrations.The efficiency was measured by color removal and TOC removal.The optimum conditions obtained for treatment of different dye wastewater were different.The treatment of Indanthrene red(FBB) by UV/TiO2 was the best,with 99.68% of TOC removal percentage and nearly 100% of color removal while treatment of FBL with 96.11% of TOC removal and almost 100% of color removal.The removal efficiency was lowest for S-RL dye solution with 81.88% of TOC and 95.87% for color removal.Both Langmuir adsorption isotherm and modified Langmuir-Hinshelwood kinetic model(modified L-H model) were fitted to the experimental data and were able to correlate the adsorption patterns and the kinetics of the dyes studied.Since the photocatalysts(TiO2) used were nano-sized powder and is difficult to separate from the wastewater,the second part of this research focuses on the preparation of TiO2-film on glass-substrate and the treatment of simulated FBL dye wastewater by UV/TiO2-film oxidation then followed.The experimental results showed the TiO2-films are suitable only for the dye wastewater treatment in low concentration. | Ruth Yu-li Yeh Shen P W Liu Robert Hung Yung-tse | 2007 | 武汉理工大学学报2007，29，10： | 2 |
| 4 | Capillary electrophoresis of methyl subsliluted phenol in acetonilrile 显示文摘 | Porras Simo P Kuldvce Ruth Palonen Sami | 2003 | Journal of Chromatography A2003，990，12： | 1 |
| 5 | Gas chromatography/snitIing port analysis and sensory evaluation of commercially dried bell peppers(Capsicum annuum) after rehydration显示文摘 | Van Ruth S M Roozen J P | 1994 | Food Chemistry1994，51，： | 1 |
| 6 | Regional energy demand responses to climate change methodology and application to the commonwealth of Massachusetts 显示文摘 | Amato A D Ruth M Kirshen P | 2005 | Climate Change2005，71，1： | 1 |
| 7 | Pivotal role of the interstitial cells of cajal in the nitric oxide signaling pathway of rat small intestine显示文摘 | Salmhofer H Neuhuber WL Ruth P | | 0，，： | 1 |
| 8 | Development and characterization of composite edible films based on whey protein isolate and mesquite gum显示文摘 | Javier O Mayra F V Ruth P I | 2009 | Journal of Food Engineering2009，92，1： | 1 |
| 9 | In vitro binding of matrix metalloproteinase-2 (MMP-2), MMP-9,and bacterial collagenase on collagenous wound dressings 显示文摘 | Metzmacher I Ruth P Abel M | 2007 | Wound Repair Regen2007，15，4： | 1 |
| 10 | Therapeuticuse of citrulline in cardiovascular disease显示文摘 | MARITZA J R DANIEl H P RUTH B C | 2006 | Cardiovascul Drug Rev2006，24，34： | 1 |
| 11 | The impact of preoper- ative stoma site marking on the incidence of complica- tions, quality of life, and patient ~ s independence 显示文摘 | Benjamin P Ruth I Jesse L | 2012 | Dis Colon Rectum2012，55，7： | 1 |
| 12 | Enhancement and inhibition of microbial activity in hydrocarbon- contaminated arctic soils: implications for nutrient-amended bioremediation 显示文摘 | BRADDOCK J F RUTH M L CATTERALL P H | 1997 | Environ- mental Science & Technology1997，，31： | 1 |
| 13 | Endoplasmic reticulum stress links dyslipidemia to inhibition of proteasome activity and glucose transport by HIV protease inhibitors 显示文摘 | Rex A Parker Oliver P Flint Ruth Mulvey | 2005 | Mol Pharmacol2005，67，6： | 1 |
| 14 | The Prevention of dementia 显示文摘 | Ruth P | 2009 | International Journal of Geriatric Psychiatry2009，24，： | 1 |
| 15 | Static Equivalency in Progressive Collapse Alternate Path Analysis : Reducing Conservatism While Retaining Structural Integrity 显示文摘 | Ruth P Marchand K A Williamson E B | 2006 | Journal of Performance of Constructed Facilities2006，20，4： | 1 |
| 16 | Global consequences of land use显示文摘 | Jonathan A Foley Ruth DeFiles Gregory P Asner | 2005 | Science2005，309，： | 1 |
| 17 | Global consequences oi land use显示文摘 | Jonathan A Foley Ruth DeFries Gregory P Asner etal | 2005 | Science2005，309，5734： | 1 |
| 18 | Erythropoietin effects on dendritic cells:Potential mediators in its function as an immunomodulator显示文摘 | SARA P S LILACH L RUTH O | | 0，，12： | 1 |
| 19 | The origin of overpressure in the Carnarvon Basin, Western Australia: implications for pore pressure prediction 显示文摘 | Ruth P V Hillis R Tingate P | 2004 | Petroleum Geoscience2004，10，247： | 1 |
| 20 | Estimation of a photon energy spectrum for a computed tomography scanner 显示文摘 | C Ruth P M Joseph | 1997 | Medical Physics1997，24，5： | 1 |
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