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| 1 | Immunogenetic biomarkers in inflammatory bowel diseases:Role of the IBD3 region显示文摘Many studies have demonstrated the linkage between the IBD3 region(6p21.1-23),an area which encompasses the famous human leukocyte antigen(HLA) complex,and Crohn's disease(CD) or ulcerative colitis(UC).IBD3 is the only region that meets genome-wide significance,and provides stronger evidence of the linkage than 16p13.1-16q12.2(IBD1),the locus that contains the susceptibility gene CARD15.However,despite these findings,IBD3 susceptibility genes remain elusive and unclear due to the strong linkage disequilibrium,extensive polymorphism,and high gene density that characterize this area and also due to varying allele frequencies in populations around the world.This area presents an extremely high abundance of genes,including the classical and non-classical major histocompatibility complex(MHC) class Ⅰ and Ⅱ genes,and other genes,namely MHC class Ⅲ genes tumor necrosis factor(TNF)-α and-β,and Hsp,whose proteins play key functions in immunological processes.To date,it is not clear which genes within the MHC family contribute to the IBD pathogenesis,although certain HLA alleles have been associated with IBD.Recent insights into the biological function of other genes encoded within the IBD3 region,such as the MHC class Ⅰ chain-related(MIC) genes,have led investigators to a more comprehensive exploration of this region.MHC class Ⅰ chain-related molecule A(MICA) is highly polymorphic and interacts with NKG2 D,its receptor on the surface of NK,Tγδ and T CD8+ cells.Increased expression of MICA in intestinal epithelial cells and increased expression of NKG2 D in CD4+ T cells(lamina propria) in patients with CD have also been reported.MICA alleles have also been associated with IBD,and a variation at amino acid position 129 of the α2-heavy chain domain seems to categorize MICA alleles into strong and weak binders of NKG2 D receptor,thereby influencing the effector cells' function.In this regard,a relevant role of MICA-129-Val/Met single nucleotide polymorphism has recently been implicated in the pathogenesis of IBD.TNF-α and-β also play an important role in inflammatory response.In fact,IBD is commonly treated with TNF-α inhibitors.Additionally,polymorphisms of TNF-α gene are known to affect the gene expression level and particular TNF-α genotypes may influence the response of IBD patients treated with TNF-α inhibitors. | Manuel Muro Ruth López-Hernández Anna Mrowiec | 2014 | World Journal of Gastroenterology2014，20，41： | 6 |
| 2 | Re-challenge chemotherapy with gemcitabine plus carboplatin in patients with non-small cell lung cancer显示文摘Despite recent improvements to current therapies and the emergence of novel agents to manage advanced non-small cell lung cancer(NSCLC),the patients′overall survival remains poor.Re-challenging with first-line chemotherapy upon relapse is common in the management of small cell lung cancer but is not well reported for advanced NSCLC.NSCLC relapse has been attributed to acquired drug resistance,but the repopulation of sensitive clones may also play a role,in which case re-challenge may be appropriate.Here,we report the results of re-challenge with gemcitabine plus carboplatin in 22 patients from a single institution who had previously received gemcitabine plus platinum in the first-line setting and had either partial response or a progression-free interval of longer than 6 months.In this retrospective study,the charts of patients who underwent second-line chemotherapy for NSCLC in our cancer center between January 2005 and April 2010 were reviewed.All the patients who received a combination of gemcitabine and carboplatin for re-challenge were included in the study.These patients were offered second-line treatment on confirmation of clear radiological disease progression.The overall response rate was 15%and disease control rate was 75%.The median survival time was 10.4 months,with 46%of patients alive at 1 year.These results suggest that re-challenge chemotherapy should be considered in selected patients with radiological partial response or a progression-free survival of longer than 6 months to the initial therapy. | Khurum Khan Gerard G Hanna Lynn Campbell Paula Scullin Adnan Hussain Ruth L Eakin Jonathan McAleese | 2013 | Chinese Journal of Cancer2013，32，10： | 3 |
| 3 | Human Papillomavirus (HPV) DNA Copy Number Is Dependent on Grade of Cervical Disease and HPV Type显示文摘 | David C S Ruth A T Guillermo T L | 1999 | Clin Microbiol1999，37，： | 1 |
| 4 | Characterization and expression pattern of zebrafish anti-Mullerian hormone (AMH) relative to sox9a, sox9b, and cyp191a, during gonad development 显示文摘 | Adriana R M Yan Y L Ruth A B | 2005 | Gene Expression Patterns2005，5，： | 1 |
| 5 | Evaluation of reporting timeliness ofpublic health surveillance systems for infectious diseases显示文摘 | Ruth Ann Jajosky Samuel L Groseclose | 2004 | BMC Public Health2004，4，29： | 1 |
| 6 | Effects of Unilateral Input and Mode of Hearing in the Better Ear: Self-reported Performance Using the Speech, Spatial and Qualities of Hearing Scale显示文摘 | No?l Y. Dwyer Jill B. Firszt Ruth M. Reeder | 2014 | Ear and Hearing2014，，1： | 1 |
| 7 | On the behavior of the ASR catamaran in waves显示文摘 | Wahab R Pritchett C Ruth L C | 1971 | Marine Technology1971，8，3： | 1 |
| 8 | Expandable metal stents for the palliation of malignant gastroduodenal obstruction显示文摘 | Rudeean R Hans -Ulrich L Ruth E | 2001 | Cardiovasc Intervent Radiol2001，24，5： | 1 |
| 9 | Energy from municipal solid waste: A comparison with coal combustion technology显示文摘 | RUTH L A | 1998 | Prog Energy Combust Sci1998，24，6： | 1 |
| 10 | The impact of preoper- ative stoma site marking on the incidence of complica- tions, quality of life, and patient ~ s independence 显示文摘 | Benjamin P Ruth I Jesse L | 2012 | Dis Colon Rectum2012，55，7： | 1 |
| 11 | Root anatomy, morphology, and longevity among root orders in Vaccinium corymbosum (Ericaceae)显示文摘 | Valenzuela-Estrada L R Vera-Caraballo V Ruth L E | 2008 | American journal of botany2008，95，12： | 1 |
| 12 | Enhancement and inhibition of microbial activity in hydrocarbon- contaminated arctic soils: implications for nutrient-amended bioremediation 显示文摘 | BRADDOCK J F RUTH M L CATTERALL P H | 1997 | Environ- mental Science & Technology1997，，31： | 1 |
| 13 | Role of laparoscopic treatment of endometriosis :in patients with failed in vitro fertilization cycles显示文摘 | Eva L Linda G Ruth L | 2005 | Fertil Steril2005，84，6： | 1 |
| 14 | The creative process:A functional model based on empirical studies from early childhood to middle age 显示文摘 | Ruth L R | 1991 | American iournal of psychiatry1991，148，8： | 1 |
| 15 | ls a Company Known by the compa- ny, It keeps assessing the spiUover effect of brand alliance on consumer brand attitudes 显示文摘 | Simonin B L and Ruth J A | 1998 | Journal of marketing research1998，，2： | 1 |
| 16 | Oral Health and Care in the Intensive Care Unit:State of the Science显示文摘 | Munro C L Grap M J Ruth K | 2004 | Am J Crit Care2004，13，1： | 1 |
| 17 | Is a Company Known by the Company It Keeps:Assessing the Spillover Effects of B Rand Alliances on Consumer B Rand Attitudes显示文摘 | SIMONIN B L RUTH J A | 1998 | Journal of Marketing Research1998，35，1： | 1 |
| 18 | is a Company Known by the Company It Keeps? Assessing the Spilovcr Effects of Brand Alliances on Consumer Brand Attitudes显示文摘 | BERNARD L SIMONIN JULIE A RUTH | 1998 | Journal of Marketing Research1998，35，1： | 1 |
| 19 | Is a Company Knownby the Company It Keeps? Assessing The SpilloverEffects of Brand AlliancevS on Consumer Brand Atti-tudes显示文摘 | SIMONIN B L RUTH J A | 1998 | Journal of Marketing Research1998，35，2： | 1 |
| 20 | Erythropoietin effects on dendritic cells:Potential mediators in its function as an immunomodulator显示文摘 | SARA P S LILACH L RUTH O | | 0，，12： | 1 |
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