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| 1 | The immune modifying effects of amino acids on gut-associated lymphoid tissue显示文摘The intestine and the gut-associated lymphoid tissue(GALT) are essential components of whole body immune defense,protecting the body from foreign antigens and pathogens,while allowing tolerance to commensal bacteria and dietary antigens.The requirement for protein to support the immune system is well established.Less is known regarding the immune modifying properties of individual amino acids,particularly on the GALT.Both oral and parenteral feeding studies have established convincing evidence that not only the total protein intake,but the availability of specific dietary amino acids(in particular glutamine,glutamate,and arginine,and perhaps methionine,cysteine and threonine) are essential to optimizing the immune functions of the intestine and the proximal resident immune cells.These amino acids each have unique properties that include,maintaining the integrity,growth and function of the intestine,as well as normalizing inflammatory cytokine secretion and improving T-lymphocyte numbers,specific T cell functions,and the secretion of IgA by lamina propria cells.Our understanding of this area has come from studies that have supplemented single amino acids to a mixed protein diet and measuring the effect on specific immune parameters.Future studies should be designed using amino acid mixtures that target a number of specific functions of GALT in order to optimize immune function in domestic animals and humans during critical periods of development and various disease states. | Megan R Ruth Catherine J Field | 2013 | Journal of Animal Science and Biotechnology2013，4，3： | 11 |
| 2 | Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-Ⅱ显示文摘 | Rosa Montes Gertrudis Ligero Laura Sanchez Purificacidn Catalina Teresa de la Cueva Ana Nieto Gustavo J Melen Ruth Rubio Javier Garcia-Castro Clara Bueno Pablo Menendez | 2009 | Cell Research2009，19，6： | 7 |
| 3 | The Role of the Innate Immune System of the Liver in the Control of HBV and HCV显示文摘Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infection are among the most frequent causes of chronic liver disease worldwide. As recent studies suggested that Toll like receptor (TLR)-based therapies may represent a promising approach in the treatment of HBV infection, we have studied the role of the local innate immune system of the liver as possible mediator of this effect. Murine non-parenchymal liver cells (NPC; Kupffer cells, KC; sinusoidal endothelial cells, LSEC) were isolated from C57/BL6 and stimulated by TLR 1-9 agonists. Supernatants were harvested and assayed for their antiviral activity against HBV in HBV-Met cells and HCV in the murine HCV replicon cell line MH1. Only supernatants from TLR 3 and -4 stimulated KC and TLR 3 stimulated LSEC were able to potently suppress HBV and HCV replication. By using neutralizing antibodies we could demonstrate that the TLR 3-but not the TLR 4 mediated effect is exclusively mediated through IFN-β. Our data indicate that TLR 3 and -4 mediated stimulation of NPC leads to production of IFN-β which can potently suppress HBV and HCV replication. This is of relevance for the local control of viral hepatitis infection by the innate immune system of the liver, the development of novel TLR-based therapeutic approaches and sheds new light on the viral crosstalk between HCV (TLR 3 stimulator) and HBV. | Ruth Brring Jrg F. Schlaak | 2008 | Virologica Sinica2008，23，2： | 4 |
| 4 | Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis显示文摘 | Andrea Reinartz Josef Ehling Andrea Leue Christian Liedtke Ursula Schneider Jürgen Kopitz Thomas Weiss Claus Hellerbrand Ralf Weiskirchen Ruth Knüchel Nikolaus Gassler | 2010 | BBA - Molecular and Cell Biology of Lipids2010，，9： | 2 |
| 5 | A new family of mesoporous molecular sieves prepared with liquid crystal templates 显示文摘 | Beck J S Vartuli J C Ruth W J | 1992 | Journal of American Chemical Society1992，114，10： | 1 |
| 6 | Iliac Crest Bone Graft Harvest Donor Site Morbidity: A Statistical Evaluation显示文摘 | J Christopher Banwart Marc A. Asher Ruth S. Hassanein | 1995 | Spine1995，，9： | 1 |
| 7 | P0tential of low- molecular chitosan as a DNAdelivery system : biocompatility, bo- dydistribution and ability to complex and protect DNA显示文摘 | Simon C W R Hanno V J K Ruth D | 1999 | Inter- national Journal of Pharrnacentics1999，178，： | 1 |
| 8 | Studies of the uptake of nitrate barley显示文摘 | SIDDIGI M Y GLASS A D M RUTH T J | 1990 | Plant Physiology1990，93，： | 1 |
| 9 | Gas chromatography/snitIing port analysis and sensory evaluation of commercially dried bell peppers(Capsicum annuum) after rehydration显示文摘 | Van Ruth S M Roozen J P | 1994 | Food Chemistry1994，51，： | 1 |
| 10 | Studies of theuptake of nitrate in barley显示文摘 | Siddiqi M Y Glass A D Ruth T J | 1990 | Plant Physiology1990，，93： | 1 |
| 11 | Global consequences of land use显示文摘 | FOLEY J A RUTH D ASNER G F | 2005 | Science2005，309，5734： | 1 |
| 12 | A new family of mesoporous molecular sieves prepared with liquid crystal templates显示文摘 | Beck J S Vartuli J C Ruth W J | 1992 | J Am Chem Soc1992，114，10： | 1 |
| 13 | FSW takes off at Boeing显示文摘 | Ruth J M | 1999 | Welding Journal1999，，2： | 1 |
| 14 | Odor thresholds and irritation levels of several chemical substances: a review显示文摘 | RUTH J H | 1986 | American Industrial Hygiene Association Journal1986，47，3： | 1 |
| 15 | Therapeuticuse of citrulline in cardiovascular disease显示文摘 | MARITZA J R DANIEl H P RUTH B C | 2006 | Cardiovascul Drug Rev2006，24，34： | 1 |
| 16 | Toxicity of cytore- ductive surgery and hyperthermic in- traperitoneal chemotherapy 显示文摘 | Verwaal V J van Tinteren H Ruth S V Zoetmulder F A | 2004 | J Surg Oncol2004，85，2： | 1 |
| 17 | Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer显示文摘 | Verwaal V J Van Ruth S De Bree E | | 0，，20： | 1 |
| 18 | Aerodynamic characteristics, database development, and flight simulation of the X-34 vehicle显示文摘 | Ruth M J Fuhrmann H D | 2001 | Journal of SpacecraR and Rocket2001，38，3： | 1 |
| 19 | Enhancement and inhibition of microbial activity in hydrocarbon- contaminated arctic soils: implications for nutrient-amended bioremediation 显示文摘 | BRADDOCK J F RUTH M L CATTERALL P H | 1997 | Environ- mental Science & Technology1997，，31： | 1 |
| 20 | Health-related quality of life and psychosocial adjustment in steroid-sensitive nephrotic syndrome 显示文摘 | RUTH E M LANDOLT M A NEUHAUS T J el al | 2004 | J Pediatr2004，145，6： | 1 |
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