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| 1 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 2 | Insulin activates vascular endothelial growth factor in vascular smooth muscle ceils: infuence of nitric oxide and of insulin resistance 显示文摘 | Doronzo G Russo I Mattiello L | 2004 | European Journal of Clinical Investigation2004，34，10： | 1 |
| 3 | Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: Implications on lung carcinogenesis 显示文摘 | Catassi A Servent D Paleari L Cesario A Russo P | 2008 | Murat Res2008，659，3： | 1 |
| 4 | Influence of wavelength on fractionation in laser ablation ICP-MS 显示文摘 | Russo R E Mao X L Borisov 0 V Liu H C | 2000 | Journal of Analytical Atomic Spectrometry2000，15，： | 1 |
| 5 | Randomised prospective study on renal effects of two different contrast media in humans: protective role of a calcium channel blocker显示文摘 | Russo D Testa A Della Volpe L | 1990 | Nephron1990，55，3： | 1 |
| 6 | A four-channel,low-power CMOS charge preamplifier for silicon detectors with medium value of capacitance显示文摘 | RANDAZZO N RUSSO G V PRESTI D L | 1997 | IEEE Transactions on Nuclear Science1997，44，1： | 1 |
| 7 | Oxidation of propane and propylerie to acrylic acid over vanadyl pyrophosphate显示文摘 | Landi G Lisi L Russo G | 2005 | Journal of Molecular Catalysis A : Chemical2005，239，： | 1 |
| 8 | Clinical value of maltidetector CT coronary angiography as a preoperative screening test before non-coronary cardiac surgery显示文摘 | Russo V Gostoli V Lovato L | | 0，，： | 1 |
| 9 | All trans-retinoic acid modulates the procoagulant activity of human breast cancer cells显示文摘 | Marchetti M Russo L Balducci D | | 0，，04： | 1 |
| 10 | Single and combined deactivating effect of alkali metals and HCl on commercial SCR catalysts显示文摘 | L Lisi G Lasorella S Malloggi G Russo | 2004 | Applied Catalysis B Environmental2004，，4： | 1 |
| 11 | Single nucleotide polymorphisms in several porcine cathepsin genes are associated with growth,carcass and production traits in Italian large white pigs显示文摘 | Russo V Fontanesi L Scotti E | 2008 | Journal of Animal Science2008，86，： | 1 |
| 12 | Drug release from carbomer934 matrics显示文摘 | Russo L I Ghaly E S | 2000 | Puerto Rico Health Sci J2000，19，2： | 1 |
| 13 | Procoagulant mechanisms in tumour cells 显示文摘 | Falanga A Panova-Noeva M Russo L | 2009 | Best Pratt Res Clin Haematol2009，22，1： | 1 |
| 14 | Risk of colorectal cancer following colonoscopic polypectomy 显示文摘 | Bertario L Russo A Sala P | 1999 | Tumor1999，85，3： | 1 |
| 15 | Intelligent field devices: user expectations 显示文摘 | CAPETTA L MELLA A RUSSO F | 1995 | Computing & Control Engineering Journal1995，6，6： | 1 |
| 16 | Mucin gene expression in human male urogenital tract epithelia 显示文摘 | Russo C L Spurr-Michaud S Tisdale A | 2006 | Human Reprod2006，21，11： | 1 |
| 17 | Modulation of nephrin in the diabetic kidney:association with systemic hypertension and increasing albuminuria 显示文摘 | Forbes J M Bonnet F Russo L M | 2002 | J Hypertens2002，20，5： | 1 |
| 18 | Randomised prospective study on renal effects of two different fast media in humans, protective role of a calcium channel blocker显示文摘 | Russo D Testa A Della Volpe L | 1990 | Nephron1990，55，3： | 1 |
| 19 | Genetics of McCune-Albright syndrome显示文摘 | De Sanctis L Delmastro L Russo MC | 2006 | J Pediatr Endocrinol Metab2006，192，： | 1 |
| 20 | Immune activation and chronic inflammation as the cause of malignancy in oral lichen pla- nus: is there any evidence 显示文摘 | Mignogna MD Fedele S Lo Russo L | 2004 | Oral Oncol2004，40，2： | 1 |
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