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| 1 | The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer显示文摘Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous cells1 that play crucial negative regulatory roles in immune-associated diseases,including infections,2 cancer,3 transplantation4,and autoimmunity.5 We and others have shown that mTOR signaling and its downstream metabolic pathways regulate MDSC recruitment and function in inflammation and autoimmunity. | Anna Jia Yuexin Wang Yufei Wang Yan Li Qiuli Yang Yejin Cao Ying He Lin Dong Yingjie Dong Yueru Hou Ruoning Wang Yujing Bi Guangwei Liu | 2021 | Cellular & Molecular Immunology2021，18，4： | 7 |
| 2 | Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis显示文摘Immunomodulatory signaling imposes tight regulations on metabolic programs within immune cells and consequentially determines immune response outcomes.Although the glucocorticoid receptor(GR)has been recently implicated in regulating the function of myeloid-derived suppressor cells(MDSCs),whether the dysregulation of GR in MDSCs is involved in immune-mediated hepatic diseases and how GR regulates the function of MDSCs in such a context remains unknown.Here,we revealed the dysregulation of GR expression in MDSCs during innate immunological hepatic injury(IMH)and found that GR regulates the function of MDSCs through modulating HIF1α-dependent glycolysis.Pharmacological modulation of GR by its agonist(dexamethasone,Dex)protects IMH mice against inflammatory injury.Mechanistically,GR signaling suppresses HIF1αand HIF1α-dependent glycolysis in MDSCs and thus promotes the immune suppressive activity of MDSCs.Our studies reveal a role of GR-HIF1αin regulating the metabolism and function of MDSCs and further implicate MDSC GR signaling as a potential therapeutic target in hepatic diseases that are driven by innate immune cell-mediated systemic inflammation. | Yun Lu Huanrong Liu Yujing Bi Hui Yang Yan Li Jian Wang Zhengguo Zhang Yu Wang Chunxiao Li Anna Jia Linian Han Ying Hu Yong Zhao Ruoning Wang Guangwei Liu | 2018 | Cellular & Molecular Immunology2018，15，6： | 4 |
| 3 | Gather wisdom to overcome barriers:Well-designed nano-drug delivery systems for treating gliomas显示文摘Due to the special physiological and pathological characteristics of gliomas,most therapeutic drugs are prevented from entering the brain.To improve the poor prognosis of existing therapies,researchers have been continuously developing non-invasive methods to overcome barriers to gliomas therapy.Although these strategies can be used clinically to overcome the blood-brain barrier(BBB),the accurate delivery of drugs to the glioma lesions cannot be ensured.Nano-drug delivery systems(NDDS)have been widely used for precise drug delivery.In recent years,researchers have gathered their wisdom to overcome barriers,so many well-designed NDDS have performed prominently in preclinical studies.These meticulous designs mainly include cascade passing through BBB and targeting to glioma lesions,drug release in response to the glioma microenvironment,biomimetic delivery systems based on endogenous cells/extracellular vesicles/protein,and carriers created according to the active ingredients of traditional Chinese medicines.We reviewed these well-designed NDDS in detail.Furthermore,we discussed the current ongoing and completed clinical trials of NDDS for gliomas therapy,and analyzed the challenges and trends faced by clinical translation of these well-designed NDDS. | Jiwei Cui Yuanxin Xu Haiyan Tu Huacong Zhao Honglan Wang Liuqing Di Ruoning Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 2 |
| 4 | Multidimensional Least-Squares Fitting with a Fuzzy Model显示文摘 | Ruoning Xu Chulin Lin | 2001 | Fuzzy Sets and Systems2001，，119： | 1 |
| 5 | Towards an understanding of cloud computing's impact on organizational it strategy显示文摘 | Qian Ruoning Prashant Palvia | 2013 | Journal of Information Technology Case and Application Research2013，15，4： | 1 |
| 6 | Extensions of the Analytic Hierarchy Process in Fuzzy Environment显示文摘 | Xu Ruoning Zhai Xiaoyan | 1992 | Fuzzy sets and Systems1992，52，： | 1 |
| 7 | Fuzzy Least-squares Priority Method in the Analytic Hierarchy Process显示文摘 | Xu Ruoning | 2000 | Fuzzy Sets and Systems2000，112，3： | 1 |
| 8 | Analysis of Supply Chain Coordination Under Fuzzy Demand in a Two - stage Supply Chain 显示文摘 | Ruoning Xu Xiaoyan Zhai | 2010 | Applied Mathematical Modeling2010，34，1： | 1 |
| 9 | Identification of a novel Astrovirus (Astrovirus VA1 ) associated with an outbreak of acute gastroenteritis 显示文摘 | Finkbeiner SR Li Y Ruone S | 2009 | J Virol2009，83，10： | 1 |
| 10 | Optimal models for single-period supply chain problems with fuzzy demand显示文摘 | RUONING XU XIAOYAN ZHAI | 2008 | Information Sciences2008，178，17： | 1 |
| 11 | Approximated Unimodal Region Elimination Based Global Optimisation Method for Engineering Design显示文摘 | Younis Adel Xu Ruoning Dong Zuomin | 2009 | International Journal of Product Development2009，9，123： | 1 |
| 12 | Fuzzy logarithmic least squares ranking method in analytic hierarchy process显示文摘 | Xu Ruoning Zhai Xiaoyan | 1996 | Fuzzy Sets and Systems1996，，2： | 1 |
| 13 | c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells显示文摘 | Zuqin Nie Gangqing Hu Gang Wei Kairong Cui Arito Yamane Wolfgang Resch Ruoning Wang Douglas R. Green Lino Tessarollo Rafael Casellas Keji Zhao David Levens | 2012 | Cell2012，，1： | 1 |
| 14 | Fuzzy Logarithmic Least Squares Ranking Method in Analytic Hierarchy Process显示文摘 | Zhai Xiaoyan | 1996 | Fuzzy Sets and Systems1996，77，： | 1 |
| 15 | Fuzzy logarithmic least squares ranking method in analytic hierarchy process显示文摘 | Xu Ruoning | 1996 | Fuzzy Set and Systems1996，，77： | 1 |
| 16 | Optimal models for single- period supply chain problems with fuzzy demand 显示文摘 | Xu Ruoning Zhai Xiaoyan | 2008 | Information Sciences2008，178，17： | 1 |
| 17 | Identification of a novel astrovirus(astrovirus VA1)associated with an outbreak of acute gastroenteritis显示文摘 | Finkbeiner S R Li Y Ruone S Conrardy C Gregoricus N Toney D Virgin H W Anderson L J VinjéJ Wang D Tong S | 2009 | J Virol2009，83，10： | 1 |
| 18 | Analysis of supply chain coordination under fuzzy demand in a two-stage supply chain显示文摘 | Xu Ruoning Zhai Xiaoyan | 2010 | Applied Mathematical Modelling2010，34，1： | 1 |
| 19 | Fuzzy least-squares priority in the analytic hierarchy process显示文摘 | Ruoning X | 2000 | Fuzzy Sets and Systems2000，，112： | 1 |
| 20 | Identification of a novel astrovirus(astrovirus VA1)associated with an outbreak of acute gastroenteritis显示文摘 | Finkbeiner SR Li Y Ruone S | | 0，，20： | 1 |
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