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| 1 | Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditis elegans显示文摘Arginine catabolism involves enzyme-dependent reactions in both mitochondria and the cytosol,defects in which may lead to hyperargininemia,a devastating developmental disorder.It is largely unknown if defective arginine catabolism has any effects on mitochondria.Here we report that normal arginine catabolism is essential for mitochondrial homeostasis in Caenorhabditis elegans.Mutations of the arginase gene argn-1 lead to abnormal mitochondrial enlargement and reduced adenosine triphosphate(ATP)production in C elegans hypodermal cells.ARGN-1 localizes to mitochondria and its loss causes arginine accumulation,which disrupts mitochondrial dynamics.Heterologous expression of human ARGl or ARG2 rescued the mitochondrial defects of argn-1 mutants.Importantly,genetic inactivation of the mitochondrial basic amino acid transporter SLC-25A29 or the mitochondrial glutamate transporter SLC-25A18.1 fully suppressed the mitochondrial defects caused by argn-1 mutations.These findings suggest that mitochondrial damage probably contributes to the pathogenesis of hyperargininemia and provide clues for developing therapeutic treatments for hyperargininemia. | Ruofeng Tang Xin Wang Junxiang Zhou Fengxia Zhang Shan Zhao Qiwen Gan Liyuan Zhao Fengyang Wang Qian Zhang Jie Zhang Guodong Wang Chonglin Yang | 2020 | Journal of Genetics and Genomics2020，47，3： | 2 |
| 2 | MCCD: muhi core collision detection between deformable models using fron! based decomposition 显示文摘 | Tang Min Manocha D Tong Ruofeng | 2010 | Graphical Models2010，72，2： | 1 |
| 3 | Multi-core collision detection between deformable models using frontbased decomposition显示文摘 | Tang Min Manocha D Tong Ruofeng | | 0，，02： | 1 |
| 4 | Sphere Face Model: A 3D morphable model with hypersphere manifold latent space using joint 2D/3D training显示文摘3D morphable models(3DMMs)are generative models for face shape and appearance.Recent works impose face recognition constraints on 3DMM shape parameters so that the face shapes of the same person remain consistent.However,the shape parameters of traditional 3DMMs satisfy the multivariate Gaussian distribution.In contrast,the identity embeddings meet the hypersphere distribution,and this conflict makes it challenging for face reconstruction models to preserve the faithfulness and the shape consistency simultaneously.In other words,recognition loss and reconstruction loss can not decrease jointly due to their conflict distribution.To address this issue,we propose the Sphere Face Model(SFM),a novel 3DMM for monocular face reconstruction,preserving both shape fidelity and identity consistency.The core of our SFM is the basis matrix which can be used to reconstruct 3D face shapes,and the basic matrix is learned by adopting a twostage training approach where 3D and 2D training data are used in the first and second stages,respectively.We design a novel loss to resolve the distribution mismatch,enforcing that the shape parameters have the hyperspherical distribution.Our model accepts 2D and 3D data for constructing the sphere face models.Extensive experiments show that SFM has high representation ability and clustering performance in its shape parameter space.Moreover,it produces highfidelity face shapes consistently in challenging conditions in monocular face reconstruction.The code will be released at http://gffzz188fe103f8f1460as5xn95cvp6f5f6fqx.ffgz.tsg.suse.edu.cn/a686432/SIR. | Diqiong Jiang Yiwei Jin Fang-Lue Zhang Zhe Zhu Yun Zhang Ruofeng Tong Min Tang | 2023 | Computational Visual Media2023，9，2： | 1 |
| 5 | Multi-core collision detection between deformable models using front-based decomposition显示文摘 | Tang Min Manocha D Tong Ruofeng | 2010 | Graphical Models2010，72，2： | 1 |
| 6 | MCCD:Multi-core collision detection between deformable models using front-based decomposition显示文摘 | Min Tang Dinesh Manochab Ruofeng Tong | 2010 | Graphical Models2010，，03： | 1 |
| 7 | Efficient and robust strain limiting and treatment of simultaneous collisions with semidefinite programming显示文摘We present an efficient and robust method which performs well for both strain limiting and treatment of simultaneous collisions. Our method formulates strain constraints and collision constraints as a serial of linear matrix inequalities(LMIs)and linear polynomial inequalities(LPIs), and solves an optimization problem with standard convex semidefinite programming solvers. When performing strain limiting, our method acts on strain tensors to constrain the singular values of the deformation gradient matrix in a specified interval. Our method can be applied to both triangular surface meshes and tetrahedral volume meshes. Compared with prior strain limiting methods, our method converges much faster and guarantees triangle flipping does not occur when applied to a triangular mesh. When performing treatment of simultaneous collisions, our method eliminates all detected collisions during each iteration,leading to higher efficiency and faster convergence than prior collision treatment methods. | Zhendong Wang Tongtong Wang Min Tang Ruofeng Tong | 2016 | Computational Visual Media2016，2，2： | 0 |
| 8 | A pair of transporters controls mitochondrial Zn^(2+) levels to maintain mitochondrial homeostasis显示文摘Zn^(2+)is required for the activity of many mitochondrial proteins,which regulate mitochondrial dynamics,apoptosis and mitophagy.However,it is not understood how the proper mitochondrial Zn^(2+)level is achieved to maintain mitochondrial homeostasis.Using Caenorhabditis elegans,we reveal here that a pair of mitochondrion-localized transporters controls the mitochondrial level of Zn^(2+).We demonstrate that SLC-30A9/ZnT9 is a mitochondrial Zn^(2+)exporter.Loss of SLC-30A9 leads to mitochondrial Zn^(2+)accumulation,which damages mitochondria,impairs animal development and shortens the life span.We further identify SLC-25A25/SCaMC-2 as an important regulator of mitochondrial Zn^(2+)import.Loss of SLC-25A25 suppresses the abnormal mitochondrial Zn^(2+)accumulation and defective mitochondrial structure and functions caused by loss of SLC-30A9.Moreover,we reveal that the endoplasmic reticulum contains the Zn^(2+)pool from which mitochondrial Zn^(2+)is imported.These findings establish the molecular basis for controlling the correct mitochondrial levels for normal mitochondrial structure and functions. | Tengfei Ma Liyuan Zhao Jie Zhang Ruofeng Tang Xin Wang Nan Liu Qian Zhang Fengyang Wang Meijiao Li Qian Shan Yang Yang Qiuyuan Yin Limei Yang Qiwen Gan Chonglin Yang | 2022 | Protein & Cell2022，13，3： | 0 |
| 9 | 3D corrective nose reconstruction from a single image显示文摘There is a steadily growing range of applications that can benefit from facial reconstruction techniques,leading to an increasing demand for reconstruction of high-quality 3D face models.While it is an important expressive part of the human face,the nose has received less attention than other expressive regions in the face reconstruction literature.When applying existing reconstruction methods to facial images,the reconstructed nose models are often inconsistent with the desired shape and expression.In this paper,we propose a coarse-to-fine 3D nose reconstruction and correction pipeline to build a nose model from a single image,where 3D and 2D nose curve correspondences are adaptively updated and refined.We first correct the reconstruction result coarsely using constraints of 3D-2D sparse landmark correspondences,and then heuristically update a dense 3D-2D curve correspondence based on the coarsely corrected result.A final refinement step is performed to correct the shape based on the updated 3D-2D dense curve constraints.Experimental results show the advantages of our method for 3D nose reconstruction over existing methods. | Yanlong Tang Yun Zhang Xiaoguang Han Fang-Lue Zhang Yu-Kun Lai Ruofeng Tong | 2022 | Computational Visual Media2022，8，2： | 0 |
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