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| 1 | Amazing structure of respirasome: unveiling the secrets of cell respiration显示文摘Respirasome,执行细胞的呼吸的一台巨大的分子的机器,自从它的发现,获得了成长注意,因为呼吸是在几乎所有生活动物的最不可缺少的生物过程。respirasome 的概念更新了我们呼吸的链组织的理解,并且最最近, respirasome 的结构从清华大学由 Yangs 组解决了(Gu 等。自然 237 (7622 ): 639-643, 2016 ) 第一在这台巨大的分子的机器以内介绍了详细相互作用,并且为药设计提供了重要信息并且屏蔽。然而,细胞的呼吸的学习通过了长历史。这里,我们简短显示出呼吸的链调查的 detoured 历史,然后描述了 respirasome 的令人惊讶的结构。 | Runyu Guo Jinke Gu Meng Wu Maojun Yang | 2016 | Protein & Cell2016，7，12： | 7 |
| 2 | Structure of the intact 14-subunit human cytochrome c oxidase显示文摘 | Shuai Zong Meng Wu Jinke Gu Tianya Liu Runyu Guo Maojun Yang | 2018 | Cell Research2018，28，10： | 5 |
| 3 | Signaling pathways in vascular function and hypertension:molecular mechanisms and therapeutic interventions显示文摘Hypertension is a global public health issue and the leading cause of premature death in humans.Despite more than a century of research,hypertension remains difficult to cure due to its complex mechanisms involving multiple interactive factors and our limited understanding of it.Hypertension is a condition that is named after its clinical features.Vascular function is a factor that affects blood pressure directly,and it is a main strategy for clinically controlling BP to regulate constriction/relaxation function of blood vessels.Vascular elasticity,caliber,and reactivity are all characteristic indicators reflecting vascular function.Blood vessels are composed of three distinct layers,out of which the endothelial cells in intima and the smooth muscle cells in media are the main performers of vascular function.The alterations in signaling pathways in these cells are the key molecular mechanisms underlying vascular dysfunction and hypertension development.In this manuscript,we will comprehensively review the signaling pathways involved in vascular function regulation and hypertension progression,including calcium pathway,NO-NOsGC-cGMP pathway,various vascular remodeling pathways and some important upstream pathways such as renin-angiotensin-aldosterone system,oxidative stress-related signaling pathway,immunity/inflammation pathway,etc.Meanwhile,we will also summarize the treatment methods of hypertension that targets vascular function regulation and discuss the possibility of these signaling pathways being applied to clinical work. | Jun Ma Yanan Li Xiangyu Yang Kai Liu Xin Zhang Xianghao Zuo Runyu Ye Ziqiong Wang Rufeng Shi Qingtao Meng Xiaoping Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 4 | Research journey of respirasome显示文摘Respirasome,as a vital part of the oxidative phosphorylation system,undertakes the task of transferring electrons from the electron donors to oxygen and produces a proton concentration gradient across the inner mitochondrial membrane through the coupled translocation of protons.Copious research has been carried out on this lynchpin of respiration.From the discovery of individual respiratory complexes to the report of the high-resolution structure of mammalian respiratory supercomplex I1III2IV1,scientists have gradually uncovered the mysterious veil of the electron transport chain(ETC).With the discovery of the mammalian respiratory mega complex I2III2IV2,a new perspective emerges in the research field of the ETC.Behind these advances glitters the light of the revolution in both theory and technology.Here,we give a short review about how scientists‘see’the structure and the mechanism of respirasome from the macroscopic scale to the atomic scale during the past decades. | Meng Wu Jinke Gu Shuai Zong Runyu Guo Tianya Liu Maojun Yang | 2020 | Protein & Cell2020，11，5： | 1 |
| 5 | UQCRFSIN assembles mitochondrial respiratory complex-Ill into an asymmetric 21-subunit dimer显示文摘 | Shuai Zong Jinke Gu Tianya Liu Runyu Guo Meng Wu Maojun Yang | 2018 | Protein & Cell2018，9，6： | 1 |
| 6 | 哺乳动物呼吸链超级复合物的Ⅰ1Ⅲ2Ⅳ1结构显示文摘在哺乳动物线粒体内膜上,呼吸链复合物进一步聚合成超级复合物来进行电子传递,并转运质子形成电化学梯度用以合成ATP。此前,呼吸链超级复合物的精细结构信息并不清楚。 | Meng Wu Jinke Gu Runyu Guo Yushen Huang 杨茂君 | 2017 | 科学新闻2017，19，4： | 0 |
| 7 | Highly efficient and aberration-free off-plane grating spectrometer and monochromator for EUV—soft X-ray applications显示文摘We demonstrate a novel flat-field,dual-optic imaging EUV—soft X-ray spectrometer and monochromator that attains an unprecedented throughput efficiency exceeding 60%by design,along with a superb spectral resolution ofλ/Δλ>200 accomplished without employing variable line spacing gratings.Exploiting the benefits of the conical diffraction geometry,the optical system is globally optimized in multidimensional parameter space to guarantee optimal imaging performance over a broad spectral range while maintaining circular and elliptical polarization states at the first,second,and third diffraction orders.Moreover,our analysis indicates minimal temporal dispersion,with pulse broadening confined within 80 fs tail-to-tail and an FWHM value of 29 fs,which enables ultrafast spectroscopic and pump-probe studies with femtosecond accuracy.Furthermore,the spectrometer can be effortlessly transformed into a monochromator spanning the EUV—soft X-ray spectral region using a single grating with an aberration-free spatial profile.Such capability allows coherent diffractive imaging applications to be conducted with highly monochromatic light in a broad spectral range and extended to the soft X-ray region with minimal photon loss,thus facilitating state-of-the-art imaging of intricate nano-and bio-systems,with a significantly enhanced spatiotemporal resolution,down to the nanometer–femtosecond level. | Jie Li Kui Li Xiaoshi Zhang Dimitar Popmintchev Hao Xu Yutong Wang Ruixuan Li Guangyin Zhang Jiyue Tang Jin Niu Yongjun Ma Runyu Meng Changjun Ke Jisi Qiu Yunfeng Ma Tenio Popmintchev Zhongwei Fan | 2024 | Light(Science & Applications)2024，13，1： | 0 |
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