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| 1 | Relationship of microstructure transformation and hardening behavior of type 17-4 PH stainless steel显示文摘The relationship between the microstructure transformation of type 17-4 PH stainless steel and the aging hardening be- havior was investigated. The results showed that, when 17-4 PH stainless steel aging at 595°C, the bulk hardness of samples attains its peak value (42.5 HRC) for about 20 min, and then decreases at all time. TEM revealed the microstructure corresponding with peak hardness is that the fine spheroid-shape copper with the fcc crystal structure and the fiber-shape secondary carbide M23C6 precipitated from the lath martensite matrix. Both precipitations of copper and M23C6 are the reasons for strengthening of the alloy at this tem- perature. With the extension of holding time at this temperature, the copper and secondary carbide grow and lose the coherent rela- tionship with the matrix, so the bulk hardness of samples decreases. | Jun Wang Hong Zou Cong Li Ruling Zuo Shaoyu Qiu Baoluo Shen | 2006 | Journal of University of Science and Technology Beijing2006，13，3： | 10 |
| 2 | Lyzl4, a novel mouse sperm-related protein, is involved in fertilization显示文摘鸡类型(c 类型) 溶解酵素的角色,原型溶解酵素,在免疫在许多有机体被描绘了。在这研究,我们克隆新奇 c 类型像溶解酵素的基因, Lyzl4,它位于老鼠染色体 9F4 并且与通常认为的信号肽和一个朊酶劈开地点编码了 145 氨基酸。在酵母表示的成熟 recombinant Lyzl4 蛋白质没显示出 bacteriolytic 活动。顺序排列分析证明在 c 类型溶解酵素的 20 不变的残余中的 3 个在 Lyzl4 被改变。改变的氨基酸(D52G ) 之一位于催化领域。Lyzl4 mRNA 有选择地在成年鼠标在睾丸和 epididymis 被表示,与改变越过不同发展阶段的表达式水平。Lyzl4 蛋白质的高水平在 acrosomal 区域和尾巴的主要的片的精子上被发现。在有它的特定的抗体的精子的 Lyzl4 蛋白质的免疫中立化显著地以一种剂量依赖者方式在 vitro 授精百分比减少了,建议 Lyzl4 可能为授精是重要的。 | Ruilin Sun Ruling Shen Jun Li Guojiang Xu Jun Chi Limei Li Jianke Ren Zhugang Wang Jian Fei | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 9 |
| 3 | Combination of onconase and dihydroartemisinin synergistically suppresses growth and angiogenesis of non-small-cell lung carcinoma and mali qnant mesotheliorn~显示文摘 | Ruling Shen Jun Li Danrong Ye Qingcheng Wang Jian Fei | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 6 |
| 4 | Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles for enhanced delivery and antitumor efficacy of paclitaxel显示文摘结合的指向的药交货在细胞质的快速的药版本是强大的策略提高反癌症药的功效和还原剂离开目标效果。此处,我们描述由 pH 应答的共聚物 D 组成的一个双功能的混合 micellar 系统 -- tocopheryl 聚乙烯乙二醇 1000-blockpoly-( 氨基的酉旨)(TPGS-b-PBAE, TP ) 并且 AS1411 aptamer (恰当) 装饰了 TPGS 聚合物(Apt-TPGS ) ,它在癌症房间的血浆膜上认出过去表示的 nucleolin。反癌症药 paclitaxel (PTX ) 在恰当混合的微粒被包含,并且这些装载药的微粒有一种合适的粒子尺寸和 116.3 nm eir single-crystalline-like 的希腊语的第六个字母潜力远程的电子连接, VN MCNS 交付 1.44 的电的传导性 ??? 汰獵瀭畬 ?? ￣吗? | Jinming Zhang Rule Chen Xiefan Fang Fengqian Chen Yitao Wang Meiwan Chen | 2015 | Nano Research2015，0，1： | 6 |
| 5 | Targeting BTKwith ibrutinib in relapsed or refractory mantle-cell lymphoma显示文摘 | Wang ML Rule S Martin P | 2013 | N Engl J Med2013，369，： | 1 |
| 6 | Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma显示文摘 | Wang ML Rule S Martin P | 2013 | N Engl J Med2013，369，： | 1 |
| 7 | Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma显示文摘 | Wang ML Rule S Martin P | 2013 | N Engl J Med2013，369，6： | 1 |
| 8 | Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma显示文摘 | Wang ML Rule S Martin P | 2013 | N Engl J Med2013，369，6： | 1 |
| 9 | STAT3 and AKT signaling pathways mediate oncogenic role of NRSF in hepatocellular carcinoma显示文摘Neuron-restrictive silencer factor(NRSF)is a zinc finger protein that acts as a negative transcriptional regulator by recruiting histone deacetylases and other co-factors.It plays a crucial role in nervous system development and is recently reported to be involved in tumorigenesis in a tumor type-dependent manner;however,the role of NRSF in hepatocellular carcinoma(HCC)tumorigenesis remains unclear.Here,we found that NRSF expression was up-regulated in 27 of 49 human HCC tissue samples examined.Additionally,mice with conditional NRSF-knockout in the liver exhibited a higher tolerance against diethylnitrosamine(DEN)-induced acute liver injury and were less sensitive to DEN-induced HCC initiation.Our results showed that silencing NRSF in HepG2 cells using RNAi technology significantly inhibited HepG2 cell proliferation and severely hindered their migration and invasion potentials.Our results demonstrated that NRSF plays a pivotal role in promoting DEN-induced HCC initiation via a mechanism related to the STAT3 and AKT signaling pathways.Thus,NRSF could be a potential therapeutic target for treating human HCC. | Ming Ma Yunhe Zhou Ruilin Sun Jiahao Shi Yutong Tan Hua Yang Mengjie Zhang Ruling Shen Leon Xu Zhugang Wang Jian Fei | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 1 |
| 10 | Targeting BTK with ibrutinib in re lapsed or refractory mantle-cell lymphoma显示文摘 | Wang ML Rule S Martin P | 2013 | N Engl J Med2013，369，6： | 1 |
| 11 | Progesterone inhibits the expression of cycloxygenase-2 and interleukin-1β in neonatal rats with hypoxic ischemic brain damage显示文摘 | Xiaoyin Wang Junhe Zhang Daowen Si Ruling Shi Weihua Dong Fang Wang Li Wang Xiaojuan Li | 2014 | International Journal of Neuroscience2014，，1： | 1 |
| 12 | Targeting BTK with ibru-tinib in relapsed or refractory mantle-cell lymphoma显示文摘 | WANG ML RULE S MARTIN Vy | 2013 | TV Engl J^2013，369，6： | 1 |
| 13 | Interim results of an international,multicenter,phase 2study of bruton's tyrosine kinase(BTK)inhibitor,Ibrutinib(PCI-32765),in relapsed or refractory mantle cell lymphoma(MCL):durable efficacy and tolerability with longer follow up显示文摘 | Wang M Rule SA Martin P | 2012 | ASH Annual Meeting Abstracts2012，120，： | 1 |
| 14 | Targeting BTK with ibrutinib in relapsed or refractory mantle- cell lymphoma 显示文摘 | Wang ML Rule S Martin P | 2013 | N Engl J Med2013，369，6： | 1 |
| 15 | Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma 显示文摘 | Wang ML Rule S Martin P | 2013 | N Engl J Med2013，369，6： | 1 |
| 16 | Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma显示文摘 | Wang ML Rule S Martin P | 2013 | N Engl J Med2013，369，： | 1 |
| 17 | Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma显示文摘 | Wang ML Rule S Martin P | 2013 | N ongl J Med2013，369，1： | 1 |
| 18 | Targeting BTK with Ibrutinib in relapsed or refractory mantle-cell lymphoma 显示文摘 | Wang ML Rule S Martin P | 2013 | NEngl J Med2013，369，6： | 1 |
| 19 | Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma显示文摘 | Wang ML Rule S Martin P | 2013 | New Engl J Med2013，369，6： | 1 |
| 20 | Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma显示文摘 | Wang M L Rule S Martin P | 2013 | N Engl J Med2013，369，： | 1 |
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