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| 1 | Synthesis of Fe_3O_4@SiO_2@polymer nanoparticles for controlled drug release显示文摘Novel multifunctional nanoparticles containing a magnetic Fe3O4@SiO2 sphere and a biocompatible block copolymer poly(ethylene glycol)-b-poly(aspartate)(PEG-b-PAsp) were prepared.The silica coated on the superparamagnetic core was able to achieve a magnetic dispersivity,as well as to protect Fe3O4 against oxidation and acid corrosion.The PAsp block was grafted to the surface of Fe3O4@SiO2 nanoparticles by amido bonds,and the PEG block formed the outermost shell.The anticancer agent doxorubicin(DOX) was loaded into the hybrid nanoparticles via an electrostatic interaction between DOX and PAsp.The release rate of DOX could be adjusted by the pH value. | WU ChengLin,HE Huan,GAO HongJun,LIU Gan,MA RuJiang,AN YingLi & SHI LinQi Key Laboratory of Functional Polymer Materials,Ministry of Education Institute of Polymer Chemistry,Nankai University,Tianjin 300071,China | 2010 | Science China Chemistry2010，53，3： | 9 |
| 2 | PARAMETERS OPTIMIZATION OF CONTINUOUS WAVELET TRANSFORM AND ITS APPLICATION IN ACOUSTIC EMISSION SIGNAL ANALYSIS OF ROLLING BEARING显示文摘Morlet wavelet is suitable to extract the impulse components of mechanical fault signals. And thus its continuous wavelet transform (CWT) has been successfully used in the field of fault diagnosis. The principle of scale selection in CWT is discussed. Based on genetic algorithm,an opti-mization strategy for the waveform parameters of the mother wavelet is proposed with wavelet en-tropy as the optimization target. Based on the optimized waveform parameters,the wavelet scalogram is used to analyze the simulated acoustic emission (AE) signal and real AE signal of rolling bearing. The results indicate that the proposed method is useful and efficient to improve the quality of CWT. | ZHANG Xinming HE Yongyong HAO Rujiang CHU Fulei | 2007 | Chinese Journal of Mechanical Engineering2007，20，2： | 7 |
| 3 | Injectable dual glucose-responsive hydrogel-micelle composite for mimicking physiological basal and prandial insulin delivery显示文摘For type 1 and advanced type 2 diabetic patients, insulin replacement therapy with simulating on-demand prandial and basal insulin secretion is the best option for optimal glycemic control. However, there is no insulin delivery system yet could mimic both controlled basal insulin release and rapid prandial insulin release in response to real-time blood glucose changes. Here we reported an artificial insulin delivery system, mimicking physiological basal and prandial insulin secretion, to achieve real-time glycemic control and reduce risk of hypoglycemia. A phenylboronic acid(PBA)/galactosyl-based glucose-responsive insulin delivery system was prepared with insulin-loaded micelles embedded in hydrogel matrix. At the hyperglycemic state, both the hydrogel and micelles could swell and achieve rapid glucose-responsive release of insulin, mimicking prandial insulin secretion.When the glucose level returned to the normal state, only the micelles partially responded to glucose and still released insulin gradually. The hydrogel with increased crosslinking density could slow down the diffusion speed of insulin inside, resulting in controlled release of insulin and simulating physiological basal insulin secretion. This hydrogel-micelle composite insulin delivery system could quickly reduce the blood glucose level in a mouse model of type 1 diabetes, and maintain normal blood glucose level without hypoglycemia for about 24 h. This kind of glucose-responsive hydrogel-micelle composite may be a promising candidate for delivery of insulin in the treatment of diabetes. | Juan Lv Gang Wu Ying Liu Chang Li Fan Huang Yumin Zhang Jinjian Liu Yingli An Rujiang Ma Linqi Shi | 2019 | Science China Chemistry2019，62，5： | 5 |
| 4 | Optic and catalytic properties of gold nanoparticles tuned by homopolymers显示文摘Gold nanoparticles (GNs) are prepared through in situ reduction using NaBH4 in the presence of homopolymer PDMAEMA. The sizes of the GNs can be adjusted by alternating the molar ratio of gold to DMAEMA. Pure PDMAEMA aqueous solution shows a phase-transition at 50℃ at pH 10 and 25℃ at pH 14, while PDMAEMA-supported GNs aqueous solution shows a phase-transition at 47℃ at pH 10 because of the increasing hydrophobic property resulting from GNs. Due to the pH and tempera-ture-responsible characteristics of PDMAEMA, the resulting PDMAEMA-supported GNs exhibit pH adjustable temperature-responsive characteristics in optic and catalytic aspects. Under an acidic condi-tion (pH 2), the GNs show unchanged surface Plasmon absorbance with a peak of 518 nm in a tem-perature range from 20 to 65℃. Under a basic condition (pH 10), the GNs first show the same absorb-ance with a peak at 518 nm in a temperature range from 20 to 40℃, and then the absorbance red shifts from 518 to 545 nm as temperature increases from 40 to 65℃. When the GNs are used as catalysts to catalyze the reduction of p-nitrophenol, the catalytic activity can be adjusted by changing the permeation of reactants in the PDMAEMA layer at low and high temperatures, respectively. | CHEN Xi ZHAO DongYun ZHAO LiZhi AN YingLi MA RuJiang SHI LinQi HE QiJun CHEN Li | 2009 | Science China Chemistry2009，52，9： | 3 |
| 5 | Morphological undecimated wavelet decomposition for fault diagnostics of rolling element bearings显示文摘 | Rujiang Hao Fulei Chu | 2008 | Journal of Sound and Vibration2008，，4： | 2 |
| 6 | Morphological undecimated wavelet decomposition for fault diagnostics of rolling element bearings 显示文摘 | Hao Rujiang Chu Fulei | 2009 | Journal of Sound and Vibration2009，320，45： | 1 |
| 7 | Simulation of rotor's ax- ial rub-impact in full degrees of freedom 显示文摘 | Yuan Zhenwei Chu Fulei Hao Rujiang | 2006 | Mechanism and Machine Theory2006，42，： | 1 |
| 8 | Ex- tract semantic information from wordnet to improve text classification performance 显示文摘 | BAI Rujiang WANG Xiaoyue LIAO Junhua | 2010 | Advances in Com- puter Science and Information Technology2010，6059，： | 1 |
| 9 | Application of support vector machine based on pattern spectrum entropy in fault diagnostics of rolling element bearings 显示文摘 | Hao Rujiang Peng Zhiyong Feng Zhipeng | 2011 | Measurement Science and Technology2011，22，10： | 1 |
| 10 | Hollow spheres with a-eyelodextrin nanotube assembled shells显示文摘 | Gao Yaohua Ma Rujiang Xiong De' an | 2011 | Carbohydr Polym2011，83，4： | 1 |
| 11 | Gear damage assessment based on cyclic spectral analysis显示文摘 | Feng Zhipeng Zuo M J Hao Rujiang | 2011 | Reliability IEEE Transactions on2011，60，1： | 1 |
| 12 | Formation of complex micelles with double-responsive channels from self-assembly of two diblock copolymers 显示文摘 | Li Guiying Shi Linqi Ma Rujiang | 2006 | Angewandte Chemic-International Edition2006，45，30： | 1 |
| 13 | Morphological undecimated wavelet decomposition for fault diagnostics of rolling element bearings显示文摘 | Hao Rujiang Chu Fulei | 2009 | Journal of Sound and Vibration2009，320，45： | 1 |
| 14 | Keith J Propagation of PAMAM dendrons on silica Gel:a study on the reaction kinetics显示文摘 | Bu Jie Li Rujiang Quah Chee Wee | 2004 | Macromolecules2004，19，： | 1 |
| 15 | Gear damage assess- ment based on cyclic spectral analysis 显示文摘 | Feng Zhipeng Zuo M J Hao Rujiang | 2011 | Reliability IEEE Transactions on2011，60，1： | 1 |
| 16 | Simulation of rotor's axial rub-impact in full degrees of freedom 显示文摘 | Yuan Zhenwei Chu Fulei Hao Rujiang | 2007 | Mechanism and Mechine Theory2007，42，7： | 1 |
| 17 | Morphological undecimated wavelet decomposition for fault diagnostics of rolling element bearings显示文摘 | Rujiang Hao Fulei Chu | 2009 | Journal of Sound and Vibration2009，320，45： | 1 |
| 18 | Morphological Undecimated Wavelet Decomposition for Fault Diagnostics of Rolling Element Bearings显示文摘 | RUJIANG H FULEI CH | 2009 | Journal of Sound and Vibration2009，320，4： | 1 |
| 19 | Morphological undecimated wavelet decomposition for fault diagnostics of rolling element bearings显示文摘 | Hao Rujiang Chu Fulei | 2009 | Journal of Sound and Vibration2009，320，45： | 1 |
| 20 | Application of support vector machine based on patternspectrum entropy in fault diagnostics of rolling elementbearings显示文摘 | HAO Rujiang PENG Zhike FENG Zhipeng | 2011 | Measurement Science and Technology2011，22，： | 1 |
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