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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Interaction between cisplatin and gemcitabine in vitro and in vivo 显示文摘 | Peters G J Bergman A M Ruiz van Haperen V W | 1995 | Semin Oncol1995，22，411： | 1 |
| 3 | Choosing weights from alternative optimal solutions of dual multiplier models in DEA显示文摘 | Cooper W W Ruiz J L | 2007 | European Journal of Operational Research2007，180，1： | 1 |
| 4 | Randomized phase II comparison of dose-intense gem-citabine:thirty-minute infusion and fixed dose rate in-fusion in patients with pancreatic adenocarcinoma显示文摘 | Tempero M Plunkett W Ruiz Van Haperen V | 2003 | JClin Oncol2003，21，34： | 1 |
| 5 | Separation of liquid-liquid dispersions in a deep-layer gravity settler: Part I Experimental study of the separation process 显示文摘 | Padilla R Ruiz M C Trujillo W | 1996 | Hydrometallurgy1996，42，2： | 1 |
| 6 | Synergistic interaction between ciaplatin and gemcitabine in vitro 显示文摘 | Bergman A M Ruiz van Haperen V W Veerman G | 1996 | Clin Cancer Res1996，2，3： | 1 |
| 7 | ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells显示文摘 | Wang E C Lee J M Ruiz W G | 2005 | J Clin Invest2005，115，9： | 1 |
| 8 | Hypertriglyceridemic pancreatitis:presentation and management显示文摘 | Tsuang W Navaneethan U Ruiz L | | 0，，： | 1 |
| 9 | Randomized pahse 2 comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma显示文摘 | Tempero M Plunkett W Ruiz Van Haperen V | 2003 | J clin oncol2003，21，18： | 1 |
| 10 | Production of thermonuclear neutrons from deuterium-filled capsule implosions driven by Z-pinch dynamic hohlraums显示文摘 | RUIZ C L COOPER G W SLUTZ S A | 2004 | Physical Review Letters2004，93，01： | 1 |
| 11 | Guaiacol hydrodeoxygenation on MoS2 catalysts:Influence of activated carbon supports显示文摘 | Ruiz P E Frederick B G De Sisto W J | | 0，，： | 1 |
| 12 | Effect of Sn addition to Pt/CeO2-Al2O3 and Pt/Al2O3 catalysts:an XPS,119 Sn M6ssbauer and microcalorimetry study显示文摘 | Serrano Ruiz J C Huber G W Sanchez Castillo M A | | 0，，02： | 1 |
| 13 | Choosing weights from alternative optimal solutions of dual multiplier models in DEA显示文摘 | Cooper W W Ruiz J L | 2007 | European J of Operational Research2007，180，1： | 1 |
| 14 | Hypertriglyceridemic pancreatitis:presentation and management显示文摘 | TSUANG W NAVANEETHAN U RUIZ L | 2009 | Am J Gastroenterol2009，104，： | 1 |
| 15 | Evaporation of water droplets placed on a heated horizontal surface显示文摘 | Ruiz O E Black W Z | | 0，，05： | 1 |
| 16 | Histopathologic in the aging human cricoatT|enoid joint 显示文摘 | Casiano RR Ruiz PJ Goldstein W | 1994 | Laryngoscope1994，104，51： | 1 |
| 17 | Hypertriglyceridemic pancre- atitis : presentation and management 显示文摘 | Tsuang W Navaneethan U Ruiz L | 2009 | Am J Gastroenteyol2009，104，4： | 1 |
| 18 | Development Lengths of High-strength Self-consolidating Concrete Beams 显示文摘 | FLOYD R W RUIZ E O DO N H | 2011 | PCI Journal2011，56，4： | 1 |
| 19 | Randomized phase Ⅱ comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocar- cinoma显示文摘 | Tempero M Plunkett W Ruiz VHV | 2003 | J Clin Oneol2003，21，18： | 1 |
| 20 | Choosing weights from alternative optimal solutions of dual multiplier models in DEA显示文摘 | Cooper W W Ruiz J L | 2007 | European J of Operational Research2007，180，1： | 1 |
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