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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis?显示文摘 | Horacio N López-Basave Diaz Romero C Alejandro Padilla Rosciano Melchor Ruan J Silvio A. ?amendys-Silva Vela Sarmiento I Ruiz Molina JM Calderillo Ruiz G Flavia Morales-Vásquez Abelardo Meneses Garcia Angel Herrera-Gomez | 2013 | Cancer Management and Research (default)2013，，： | 2 |
| 3 | Quantitative age-related changes in dorsal lateral geniculate nucleus rdlay neurons of the rat显示文摘 | VIDAL L RUIZ C VILLENA A | 2004 | Neuroscience esearch2004，48，： | 1 |
| 4 | Klf4 transcription factor is expressed in the cytoplasm of prostate cancer cells显示文摘 | Le Magnen C Bubendorf L Ruiz C | 2013 | Eur J Cancer2013，49，4： | 1 |
| 5 | Production of thermonuclear neutrons from deuterium-filled capsule implosions driven by Z-pinch dynamic hohlraums显示文摘 | RUIZ C L COOPER G W SLUTZ S A | 2004 | Physical Review Letters2004，93，01： | 1 |
| 6 | Multi-classification by using tri-class SVM 显示文摘 | ANGULO C RUIZ F J GONZALEZ L | 2006 | Neural Processing Letters2006，23，1： | 1 |
| 7 | Temperature-and pH-sensitive interpenetrating polymer networks grafted on PP:cross-linking irradiation dose as a critical variable for the performance as vancomycin-eluting systems显示文摘 | Franklin M M Ruiz J C Carmen A L | 2012 | Radiation Physics and Chemistry2012，81，5： | 1 |
| 8 | Recurrent primary cerebralhemor rhage: frequency, mechanisms and prognosis显示文摘 | GONZALEZ DUARTE A CANTU C RUIZ SAN DOVAL J L | 1998 | Stroke1998，29，： | 1 |
| 9 | A new spectrophotometric method for the determination of ferrous iron in the presence of ferric iron 显示文摘 | HERRERA L RUIZ P AGUILLON J C FEHRMANN A | 1989 | Journal of Chemical Technology and Biotechnology1989，44，3： | 1 |
| 10 | The role of oxidative stress in the toxicity induces by amyloid beta-peptide in Alzheimer's disease显示文摘 | Miranda S Opazo C Larrondo L F Munoz F J Ruiz F Leigh- ton F Inestmsa N C | 2000 | Prog Neurobiol2000，62，6： | 1 |
| 11 | T2 mapping in patellar chondromalacia显示文摘 | Ruiz S F Pozuelo C R Almansa L J | 2014 | EurJRadiol2014，83，6： | 1 |
| 12 | Absolute calibration of a total yield indium activation detector for DD and DT neutrons显示文摘 | Ruiz C L Leeper R J Cooper G | 1992 | Rev Sci Instrum1992，63，10： | 1 |
| 13 | Copper activation deuterium-tritium neutron yield measurements at the National Ignition Facility 显示文摘 | Cooper G W Ruiz C L Leeper R J | 2012 | Review of Scientific Instruments2012，83，10： | 1 |
| 14 | Influence of finishing diet on fatty acid profiles of intramuscular lipids, triglycerides and phospholipids in muscles of the iberian pig显示文摘 | CAVA R RUIZ J L'PEZ-BOTE C | 1997 | Meat Science1997，45，2： | 1 |
| 15 | Treacher Collins syndrome :currnet evaluation, treatment, and future directions显示文摘 | Posnick J C Ruiz R L | 2000 | Cleft Palate Craniofac J2000，37，： | 1 |
| 16 | Analysis of micronucleated erythrocytes in heron nestlings from reference and impacted sites in the Ebro basin (N E Spain) 显示文摘 | QUIROS L RUIZ X SANPERA C | 2008 | Environmental Pollution2008，155，： | 1 |
| 17 | The effect of a ruminal nitrogen (N) deficiency in dairy cows: evaluation of the Cornell Net Carbohydrate and Protein System ruminal nitrogen deficiency adjustment显示文摘 | Ruiz R Tedeschi L O Marini J C Fox D G Pell A N Jarvis G Russell J B | 2002 | Journal of Dairy Science2002，85，： | 1 |
| 18 | Maintenance of rat taste buds in primarycuhure显示文摘 | Ruiz C J Stone L M Mcpheeters M | 2001 | ChernSenses2001，26，： | 1 |
| 19 | Development of a carbohydrate silylation method in ionic liquids for their gas chromatographic analysis 显示文摘 | Ruiz - Aceituno L Carrero - Carralero C Ramos L | 2013 | Analytica Chimica Acta2013，787，1： | 1 |
| 20 | In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis that are susceptible or resistant to first line antituberculosis drugs 显示文摘 | Aleala L Ruiz - Serrano M J Perez - Fernandez Turegano C | 2003 | Antimicrob Agents Chemother2003，47，1： | 1 |
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