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| 1 | Effect of Hot Isostatic Pressing Conditions and Cooling Rate on Microstructure and Properties of Ti-6Al-4V Alloy from Atomized Powder显示文摘The effects of temperature and pressure on density, microstructure and mechanical properties of powder compacts during hot isostatic pressing(HIPping) were investigated. Optimized HIPping parameters of temperature range from 900 to 940℃, pressure over 100 MPa and holding time of 3 h, were obtained. Tensile properties after different heat treatments show that both the geometry of samples and cooling rate have a significant influence on mechanical properties. Finite element method was used to predict the temperature field distribution during HIPped sample cooling, and the experimental results are in agreement with simulation prediction. The interaction of HIPping parameters was analyzed based on the response surface methodology(RSM) in this study. | Lei Xu Ruipeng Guo Chunguang Bai Jiafeng Lei Rui Yang | 2014 | Journal of Materials Science & Technology2014，30，12： | 24 |
| 2 | Effect of Hot Isostatic Pressing Loading Route on Microstructure and Mechanical Properties of Powder Metallurgy Ti_2AlNb Alloys显示文摘In this work, hot isostatic pressing(HIPing) technique was used to densify the Ti_2AlNb pre-alloyed powder.The influence of HIPing loading route parameters(temperature and rates of heating and pressurizing)on microstructure and properties of PM Ti_2AlNb alloys was studied. The results showed that HIPing loading route parameters affected the densification process and mechanical properties(especially high temperature rupture lifetime) of PM Ti_2AlNb alloys in the present work. A finite element method(FEM) model for predicting the final densification was developed and was used to optimize the HIPing procedure. | Jie wu Ruipeng Guo Lei Xu Zhengguan Lu Yuyou Cui Rui Yang | 2017 | Journal of Materials Science & Technology2017，33，2： | 10 |
| 3 | The effects of RFRP-3, the mammalian ortholog of GnIH, on the female pig reproductive axis in vitro显示文摘 | Xun Li Juan Su Rui Fang Lucheng Zheng Ruipeng Lei Xiaoye Wang Zhihai Lei Mengmeng Jin Yang Jiao Yuanlong Hou Tingting Guo Zhiyu Ma | 2013 | Molecular and Cellular Endocrinology (-)2013，，1： | 1 |
| 4 | Ethical framework on risk governance of synthetic biology显示文摘Synthetic biology is an emerging multidisciplinary field that aims to design and construct new biological systems not found in nature.Whereas synthetic biology may yield tremendous benefits,it may also pose substantial risks to human health and the environment that must be addressed.In this paper,we examined the environmental risks associated with synthetic biology,including changes to or depletion of the environment,competition with native species,horizontal gene transfer,pathogenicity or toxicity,bioterrorism,and laboratory biosecurity.We highlight three approaches for assessing environmental risks in synthetic biology:solution-focused risk assessment,Bayesian networks,and network of networks for sustainable capacity building.An ethical governance framework is proposed to facilitate innovation while minimising risks.This framework emphasises the precautionary principle and balancing stakeholder interests prior to project development and commercialisation.Overall,we underscore the importance and urgency of assessing and managing the environmental risks of synthetic biology to ensure its safe and ethical development and application. | Liao Bohua Wang Yuexin Ou Yakun Zuo Kunlan Liu Huan Lei Ruipeng | 2023 | Journal of Biosafety and Biosecurity2023，5，2： | 0 |
| 5 | Regulation and management of the biosecurity for synthetic biology显示文摘Synthetic biology(SynBio)is a high-profile interdiscipline combining engineering with science.As a dual-purpose discipline,SynBio is bringing large changes to many fields and providing great benefits to humans.However,due to its characteristic of complexity and uncertainty,SynBio also presents potential biosafety and biosecurity risks.Biosecurity risks refer to unauthorized access,loss,theft,misuse,diversion or intentional release.If a biosecurity accident happens,it would pose a huge threat to humans and nature.Therefore,it is crucial to establish a set of regulations and management practices for the biosecurity risks of SynBio.In this paper,we summarized the sources of the biosecurity risks of SynBio,from its research materials,products,technologies,information to Do-it-yourself synthetic biology.We reviewed and analyzed the current situation of regulation and management of biosecurity for SynBio in the international community and in China.We found that in most countries and regions,SynBio risks commonly follow the regulation and management of Genetically Modified Organisms which has loopholes if applied to the regulation for SynBio without any amendments.Here,we proposed suggestions for the Chinese-featured regulation and management of biosecurity for SynBio,including a top-to-bottom governing framework,a think-tank implementation mechanism,a Synthetic Biology Laboratory Biosecurity Manual safeguarding system,and strengthening biosecurity education on synthetic biology and self-regulation awareness among relevant personnel.Through this work,we aim to improve the standardized process of biosecurity regulation and management for SynBio in China and thereby map out a peaceful,profitable,and practical development path for synthetic biology. | Xiaomei Zeng Hailun Jiang Guangying Yang Yakun Ou Shan Lu Jia Jiang Ruipeng Lei Li Su | 2022 | Synthetic and Systems Biotechnology2022，7，2： | 0 |
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