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| 1 | Review on active thermal protection and its heat transfer for airbreathing hypersonic vehicles显示文摘Hypersonic vehicles with turbojet, ramjet, and scramjet engines are expected to be widely applied to future transportation systems. Due to high-speed flight in the atmosphere, body outer surfaces suffer strong aerodynamic heating, and on the other hand, combustion chamber inter walls are under extremely high temperature and heat flux. Therefore, more efficient and stable active cooling technologies are required in hypersonic vehicles, such as regenerative cooling, film cooling, and transpiration cooling, as well as their combinations. This paper presents a comprehensive literature review on three active cooling methods, i.e., regenerative cooling, film cooling, and transpiration cooling, and deeply analyzes the mechanism of each cooling method, including the fluids flow, heat transfer, and thermal cracking characteristics of different hydrocarbon fuels in regenerative cooling,the heat transfer and flow mechanism of film cooling under supersonic mainstream conditions, and the heat transfer and flow mechanism of transpiration cooling. | Yinhai ZHU Wei PENG Ruina XU Peixue JIANG | 2018 | Chinese Journal of Aeronautics2018，31，10： | 35 |
| 2 | Retrospective epidemiological study of thyroid nodules by ultrasound in asymptomatic subjects显示文摘 | Sharen Gaowa Zhang Bo Zhao Ruina Sun Jie Gai Xiaorong Lou Huiping | 2014 | Chinese Medical Journal2014，，9： | 17 |
| 3 | Pore-scale visualization on a depressurization-induced CO2 exsolution显示文摘The pore-scale behavior of the exsolved CO_2 phase during the depressurization process in CO_2 geological storage was investigated.The reservoir pressure decreases when the injection stops or when a leaking event or fluid extraction occurs.The exsolution characteristics of CO_2 affect the migration and fate of CO_2 in the storage site significantly.Here,a micromodel experimental system that can accommodate a large pressure variation provides a physical model with homogeneous porous media to dynamically visualize the nucleation and growth of exsolved CO_2 bubbles.The pressure decreased from 9.85 to 3.95 MPa at different temperatures and depressurization rates,and the behavior of CO_2 bubbles was recorded.At the pore-scale,the nuclei became observable when the CO_2 phase density was significantly reduced,and the pressure corresponding to this observation was slightly lower than that of the severe expansion pressure region.The lower temperature and faster depressurization rate produced more CO_2 nuclei.The exsolved CO_2 bubble preferentially grew into the pore body instead of the throat.The progress of smaller CO_2 bubbles merging into a larger CO_2 bubble was first captured,which validated the existence of the Ostwald ripening mechanism.The dispersed CO_2 phase after exsolution shows similarity with the residually trapped CO_2.This observation is consistent with the low mobility and high residual trapping ratio of exsolved CO_2 measured in the core-scale measurement,which is considered to be a self-sealing mechanism during depressurization process in CO_2 geological storage. | Ruina Xu Rong Li Feng Huang Peixue Jiang | 2017 | Science Bulletin2017，62，11： | 10 |
| 4 | Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B显示文摘作为克积极的、形成孢子的厌氧的杆菌, Clostridium 顽固(C。顽固) 为严重、致命的 pseudomembranous 大肠炎负责,并且形成世界范围的最迫切的抗菌素抵抗威胁。流行 C。顽固全球性是联系抗菌素的腹泻的领先的原因,特别由于 hypervirulent 的出现,种类与高死亡和病态联系了的腹泻。TcdB,关键毒力因素之一由这个细菌藏匿了,通过糟糕理解的机制进入主人房间得到它的病原的效果。这里,我们报导 TcdB 细胞的受体的第一鉴定, chondroitin 硫酸盐 proteoglycan 4 (CSPG4 ) 。CSPG4 开始从屏蔽的一个整个染色体的人的 shRNAmir 图书馆被孤立,并且它的角色被证实由调停 TALEN 并且在人的房间的 CRISPR/Cas9-mediated 基因大美人。CSPG4 为对房间表面有约束力的 TcdB 是批评的,导致细胞骨架混乱和房间死亡。在 CSPG4 的 N 终点和 TcdB 的 C 终点之间的一个直接相互作用被证实,并且 CSPG4 的毒素绑定领域的可溶的肽能保护房间免受 TcdB 的行动的伤害。尤其是, CSPG4/NG2 的完全的损失减少了在没有显著地影响动物死亡的老鼠的被触发 TcdB 的 interleukin-8 正式就职。基于两个在里面 vitro 并且在 vivo 研究,我们为 TcdB endocytosis 建议一个双受体的模型。第一 TcdB 受体的发现为 CSPG4 揭示一个以前不受怀疑的角色并且为 C 的处理提供一个新治疗学的目标。顽固感染。 | Pengfei Yuan Hongmin Zhang Changzu Cai Shiyou Zhu Yuexin Zhou Xiaozhou Yang Ruina He Chan Li Shengjie Guo Shan Li Tuxiong Huang Gregorio Perez-Cordon Hanping Feng Wensheng Wei | 2015 | Cell Research2015，25，2： | 6 |
| 5 | Theoretical and experimental study of the thermal conductivity of nanoporous media显示文摘The nanoparticle thermal conductivity and nanoscale thermal contact resistance were investigated by molecular dynamics(MD) simulations to further understand nanoscale porous media thermal conductivity.Macroscale porous media thermal conductivity models were then revised for nanoporous media.The effective thermal conductivities of two packed beds with nanoscale nickel particles and a packed bed with microscale nickel particles were then measured using the Hot Disk.The measured results show that the nano/microscale porous media thermal conductivities were much less than the thermal conductivities of the solid particles.Comparison of the measured and calculated results shows that the revised combined parallel-series model and the revised Hsu-Cheng model can accurately predict the effective thermal conductivities of micro-and nanoparticle packed beds. | JIANG PeiXue XIANG Heng XU RuiNa | 2012 | Science China(Technological Sciences)2012，55，8： | 5 |
| 6 | Effect of reactive surface area of minerals on mineralization trapping of CO_2 in saline aquifers显示文摘The reactive surface area, an important parameter controlling mineral reactions, affects the amount of mineralization trapping of CO2 which affects the long-term CO2 storage. The effect of the reactive surface area on the mineralization trapping of CO2 was numerically simulated for CO2 storage in saline aquifers. Three kinds of minerals, including anorthite, calcite and kaolinite, are involved in the mineral reactions. This paper models the relationship between the specific surface area and the grain diameter of anorthite based on experimental data from literature (Brantley and Mellott, 2000). When the reactive surface areas of anorthite and calcite decrease from 838 to 83.8 m2/m3, the percentage of mineralization trapping of CO2 after 500 years decreases from 11.8% to 0.65%. The amount of dissolved anorthite and the amounts of precipitated kaolinite and calcite decrease significantly when the reactive surface areas of anorthite and calcite decrease from 838 to 83.8 m2/m3. Calcite is initially dissolved in the brine and then precipitates during the geochemical reactions between CO2-H2O and the minerals. Different reactive surface areas of anorthite and calcite lead to different times from dissolution to precipitation. The pH of the brine decreases with decreasing reactive surface areas of anorthite and calcite which influences the acidity of the saline aquifer. The gas saturation between the upper and lower parts of the saline aquifer increases with decreasing reactive surface areas of anorthite and calcite. The mass density distribution of brine solution shows that the CO2+brine solution region increases with decreasing reactive surface areas of anorthite and calcite. | LUO Shu XU Ruina JIANG Peixue | 2012 | Petroleum Science2012，9，3： | 5 |
| 7 | Dietary exposure to di-isobutyl phthalate increases urinary 5-methyl-2′-deoxycytidine level and affects reproductive function in adult male mice显示文摘Phthalates are a large family of ubiquitous environmental pollutants suspected of being endocrine disruptors. Epidemiological studies have associated phthalate metabolites with decreased reproductive parameters and linked phthalate exposure with the level of urinary 5-methyl-2′-deoxycytidine(5mdC, a product of methylated DNA). In this study, adult male mice were exposed to 450 mg di-isobutyl phthalate(DiBP)/(kg·day) via dietary exposure for 28 days. Mono-isobutyl phthalate(Mi BP, the urinary metabolite) and reproductive function parameters were determined. The levels of 5mdC and 5-hydroxymethyl-2′-deoxycytidine(5hmdC) were measured in urine to evaluate if their contents were also altered by DiBP exposure in this animal model. Results showed that DiBP exposure led to a significant increase in the urinary 5mdC level and significant decreases in sperm concentration and motility in the epididymis, accompanied with reduced testosterone levels and downregulation of the P450 cholesterol side-chain cleavage enzyme(P450scc) gene in the mice testes. Our findings indicated that exposure to DiBP increased the urinary 5mdC levels,which supported our recent epidemiological study about the associations of urinary 5mdC with phthalate exposure in the male human population. In addition, DiBP exposure impaired male reproductive function, possibly by disturbing testosterone levels; P450scc might be a major steroidogenic enzyme targeted by DiBP or other phthalates. | Yitao Pan Xiaoyang Wang Leo W.Y.Yeung Nan Sheng Qianqian Cui Ruina Cui Hongxia Zhang Jiayin Dai | 2017 | Journal of Environmental Sciences2017，29，11： | 5 |
| 8 | 宁夏年降水和季节降水的创新趋势分析显示文摘采用创新趋势分析(ITA)方法对1961年至2018年宁夏不同强度降水的时空变化进行研究。结果表明,区域年降水量增加主要是弱降水增加,而区域年降水量减少主要是强降水减少;极端降水的变化趋势明显。不同类型极端降水的贡献随季节变化。春季区域降水增加主要是强降水增加,区域降水减少主要是弱降水减少。夏季和秋季区域降水增加主要是弱降水增加,而区域降水减少是由强降水减少引起。该研究结果为水资源规划和应对干旱和洪涝灾害提供了支持。 | YANG Huiling XIAO Hui GUO Chunwei SUN Yue GAO Ruina | 2020 | Atmospheric and Oceanic Science Letters2020，13，4： | 4 |
| 9 | Internal heat transfer coefficients in microporous media with rarefaction effects显示文摘The internal heat transfer of different gases in microporous media was investigated experimentally and numerically.The experimental test section had a sintered bronze porous media with average particle diameters from 11 μm to 225 μm.The Knudsen numbers at the average inlet and outlet pressures of each test section varied from 0.0006 to 0.13 with porosities from 0.16 to 0.38.The particle-to-fluid heat transfer coefficients of air,CO 2 and helium in the microporous media were determined experimentally.The results show that the Nusselt numbers for the internal heat transfer in the microporous media decrease with decreasing the particle diameter,d p,and increasing Knudsen number for the same Reynolds number.For Kn>0.01,the rarefaction affects the internal heat transfer in the microporous media.A Nusselt number correlation was developed that includes the influence of rarefaction.The computational fluid dynamics(CFD) numerical simulation was carried out to do the pore scale simulation of internal heat transfer in the microporous media considering the rarefaction effect.Pore scale three-dimensional numerical simulations were also used to predict the particle-to-fluid heat transfer coefficients.The numerical results without slip-flow and temperature jump effects for Kn<0.01 corresponded well with the experimental data.The numerical results with slip-flow and temperature jump effects for 0.01 | XU RuiNa HUANG YuLi JIANG PeiXue WANG BuXuan | 2012 | Science China(Technological Sciences)2012，55，10： | 4 |
| 10 | Gene expression dynamics during the gonocyte to spermatogonia transition and spermatogenesis in the domestic yak显示文摘Background:Spermatogenesis is a cellular differentiation process that includes three major events:mitosis of spermatogonia,meiosis of spermatocytes and spermiogenesis.Steady-state spermatogenesis relies on functions of spermatogonial stem cells(SSCs).Establishing and maintaining a foundational SSC pool is essential for continued spermatogenesis in mammals.Currently,our knowledge about SSC and spermatogenesis is severely limited in domestic animals.Results:In the present study,we examined transcriptomes of testes from domestic yaks at four different stages(3,5,8 and 24 months of age)and attempted to identify genes that are associated with key developmental events of spermatogenesis.Histological analyses showed that the most advanced germ cells within seminiferous tubules of testes from 3,5,8 and 24 months old yaks were gonocytes,spermatogonia,spermatocytes and elongated spermatids,respectively.RNA-sequencing(RNA-seq)analyses revealed that 11904,4381 and 2459 genes were differentially expressed during the gonocyte to spermatogonia transition,the mitosis to meiosis transition and the meiosis to post-meiosis transition.Further analyses identified a list of candidate genes than may regulate these important cellular processes.CXCR4,a previously identified SSC niche factor in mouse,was one of the up-regulated genes in the 5 months old yak testis.Results of immunohistochemical staining confirmed that CXCR4 was exclusively expressed in gonocytes and a subpopulation of spermatogonia in the yak testis.Conclusions:Together,these findings demonstrated histological changes of postnatal testis development in the domestic yak.During development of spermatogonial lineage,meiotic and haploid germ cells are supported by dynamic transcriptional regulation of gene expression.Our transcriptomic analyses provided a list of candidate genes that potentially play crucial roles in directing the establishment of SSC and spermatogenesis in yak. | Guowen Wang Yongchang Li Qilin Yang Shangrong Xu Shike Ma Rongge Yan Ruina Zhang Gongxue Jia Deqiang Ai Qi’en Yang | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 3 |
| 11 | Multiple Walking Speed–frequency Relations are Predicted by Constrained Optimization显示文摘 | JOHN E.A. BERTRAM ANDY RUINA | 2001 | Journal of Theoretical Biology2001，，4： | 2 |
| 12 | Inhibition effects of perfluoroalkyl acids on progesterone production in mLTC-1显示文摘Perfluoroalkyl substances(PFASs) are a class of fluorine substituted carboxylic acid, sulfonic acid and alcohol, structurally similar to their corresponding parent compounds. Previous study demonstrated the potential endocrine disruption and reproductive toxicity of perfluorooctane sulfonic acid and perfluorooctanoic acid, two dominant PFASs in animals and humans. We explored the relationship between eleven perfluoroalkyl acids(PFAAs)with different carbon chain length and their ability to inhibit progesterone production in mouse Leydig tumor cells(m LTC-1). We found an obvious dose–response relationship between progesterone inhibition rate and PFAA exposure concentration in m LTC-1. The relative inhibition rate of progesterone by PFAAs was linearly related to the carbon chain length and molar refractivity of PFAAs. Mitochondrial membrane potential(MMP) decreased after PFAA exposure at the half-maximal inhibitory effect concentration(IC_(50)) of progesterone production in m LTC-1, while the reactive oxygen species(ROS) content increased significantly. These results imply that the inhibition effect of PFAAs on progesterone production might be due, in part, to ROS damage and the decrease in MMP in m LTC-1. | Wei Zhao Ruina Cui Jianshe Wang Jiayin Dai | 2017 | Journal of Environmental Sciences2017，29，6： | 2 |
| 13 | Estimation of the age of human semen stains by attenuated total reflection Fourier transform infrared spectroscopy:a preliminary study显示文摘Semen stain is one of the most important biological evidence at sexual crime scenes.Age estimation of human semen stains plays an important role in forensic work,and it is rarely studied due to lack of well-established methods.In this study,the technique called attenuated total reflection Fourier transform infrared spectroscopy(ATR-FTIR)coupled with advanced chemometric methods was employed to determine the age of semen stains on three different substrates:glass slides,tissues and fabric made of regenerated cellulose fibres up to 6 d.Partial least squares regression(PLSR)was used in conjunction with spectral analysis for age estimation,and the results generated high R2 values(cross-validation:0.81,external validation:0.74)but a narrow margin of error for root mean square error(RMSE)(RMSE of cross-validation:0.77 d,RMSE of prediction:1.02 d).Additionally,our results indicated the robustness of PLSR model was not weaken by the influence of different substrates in this study.Our results indicate that ATR-FTIR,combined with chemometric methods,shows great potential as a convenient and efficient tool for age estimation of semen stains.Moreover,the method could be applied to routine forensic investigations in the future. | Shuai Zha Xin Wei Ruoxi Fang Qi Wang Hancheng Lin Kai Zhang Haohui Zhang Ruina Liu Zhouru Li Ping Huang Zhenyuan Wang | 2020 | Forensic Sciences Research2020，5，2： | 2 |
| 14 | Slaughtering Performance and Meat Quality of Hainan Black Goat and Its Hybrid Offsprings with Nubian Black Goat显示文摘In order to compare the slaughter performance and meat quality of Hainan black goats and hybrid offsprings of Nubian Black Goat and Hainan Black Goat, six 7-month-old Hainan black goats and six hybrid offsprings were selected to determine slaughter performance and muscle quality. The results showed that hybridization of Nubian black goat and Hainan black goat significantly improved the production performance and slaughter performance of hybrid offsprings (P>0.05). The meat quality of F1 hybrid black goat had no significant difference with that of Hainan black goat except for the hardness and elasticity (P<0.05). Therefore, the crossbred progenies of Nubian black goat and Hainan black goat have advantages in meat yield and meat performance, and the main meat quality indexes are not significantly different, which meets the market requirements for high-yield and high-quality hybrid combinations, and can be used for cross promotion. | Wei Limin Sun Ruiping Liu Yan Liu Ruina Liu Quanwei Zheng Xinli Wang Feng Huang Lili Xing Manping | 2019 | Animal Husbandry and Feed Science2019，11，2： | 2 |
| 15 | Efficient bipedal robots based on passive-dynamic walkers显示文摘 | Collins S Ruina A Tedrake R | 2005 | Science2005，307，5712： | 1 |
| 16 | Slip instability and state variable friction laws显示文摘 | RUINA A L | 1983 | Journal of Geophysical Research1983，88，10： | 1 |
| 17 | Efficient bipedal robotsbased on passive- dynamic walkers 显示文摘 | Collins S Ruina A Tedrake R | 2005 | Science2005，307，5712： | 1 |
| 18 | A two legged kneed passive dynamic walking robot 显示文摘 | Collins S H Wisse M Ruina A | 2001 | The International Journal of Robotics Research2001，20，7： | 1 |
| 19 | Clean coal technology development in China显示文摘 | Wenying Chen Ruina Xu | 2009 | Energy Policy2009，，： | 1 |
| 20 | Slip instability and state variable friction laws显示文摘 | RUINA A | 1983 | Journal of Geophysical Research1983，88，10： | 1 |
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