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| 1 | 国际卒中遗传学联盟的推荐意见(第1部分):标准化表型数据收集显示文摘与几乎所有复杂疾病一样,卒中的患病风险和临床转归也是多基因作用的[1]。探索相关基因突变有望为新型个体化治疗方法奠定基础,从而显著减少卒中对全球健康造成的毁灭性影响。为了达到足够的统计学效能以确认多个风险性等位基因,需要很大的样本量。尽管卒中是全世界范围内第二大致死病因和成年人致残的主要原因[2],但没有任何一家研究机构能独立收集到足够的样本。在认识到这一挑战之后,来自世界各地的卒中研究者们于2007年成立了国际卒中遗传学联盟( International Stroke Genetics Consortium, ISGC; http://www. strokegenetics.org),其使命是通过研究在全球多个研究机构入组的患者来识别影响卒中患病风险、临床预后和治疗效果的遗传学因素。尽管先前已取得了一些成功[3-5],仍有大量工作有待进行,这不仅是为了发现风险性等位基因从而达到卒中个体化医疗的最终目标,更是为了开发综合性卒中风险评估手段以及得到足以改变临床实践的结果[6]。根据糖尿病和冠状动脉疾病等其他复杂疾病的研究进展,为了识别与卒中相关的所有基因突变,需要100000~200000个样本。为了达到这个样本量,需要进行更为广泛的协作。 | Jennifer J. Majersik John W.Cole Jonathan Golledge Natalia S. Rost Yu-Feng Yvonne Chan M. Edip Gurol Ame G. Lindgren Daniel Woo Israel Fernandez-Cadenas Donna T. Chen Vincent Thijs Bradford B. Worrall Ayeesha Kamal Paul Bentley Joanna M. Wardlaw Ynte M. Ruigrok Thomas W.K Battey Reinhold Schmidt Joan Montaner Anne-Katrin Giese Jaume Roquer Jordi Jimenez-Conde Chaeyoung Lee Hakan Ay Juan Jose Martin 李海峰 岳耀先 徐军 | 2015 | 国际脑血管病杂志2015，23，9： | 3 |
| 2 | Genetics of intracranial aneurysms显示文摘 | Ruigrok YM Rinkel GJ Wijmenga C | 2005 | Lancet Neurol2005，4，3： | 1 |
| 3 | Attributable risk of common and rare determinants of subarachnoid hemorrhage显示文摘 | Ruigrok YM Buskens E Rinkel GJ | 2001 | Stroke2001，32，： | 1 |
| 4 | Perimesen cephalic hemorrhage and CT angiography: a decision analysis显示文摘 | Rinkel GJ Buskens E | 2000 | Stroke2000，31，12： | 1 |
| 5 | Characteristics ofintracranial aneurysms in patients with familial subarachnoidhemorrhage显示文摘 | Ruigrok YM Rinkel GJ Algra A | 2004 | Neurology2004，62，6： | 1 |
| 6 | Perimesancephalic hemorrhage and CT angiography:a decision analysis显示文摘 | Rinkel GJ Buskens E | 2000 | Stroke2000，31，： | 1 |
| 7 | The effect of verapamil on the calcium paradox 显示文摘 | Ruigrok TJC Boink ABJ Slade A | 1980 | Am J Pathol1980，98，： | 1 |
| 8 | Effect of one-HLA-DR-antigen-matched and completely HL-A-DR-mismatched blood transfusions on survival of heart and kidney allografts显示文摘 | Lagaay El Hennemann IPH Ruigrok M | 1989 | N Engl J Med1989，321，11： | 1 |
| 9 | Ultrastructural study of the GABAergic and cerebellar input to the nucleus reticularis tegmenti pontis显示文摘 | Verveer C Hawkins RK Ruigrok TJ | 1997 | Brain Res1997，766，2： | 1 |
| 10 | Internationalization and performance : an organizational learning perspective 显示文摘 | RUIGROK W WAGNER H | 2003 | Management International Review2003，，1： | 1 |
| 11 | Internationalization and perfor- mance: An organizational learning perspective显示文摘 | Ruigrok W Wagner H | 2003 | Ma- nagement International Review2003，43，1： | 1 |
| 12 | Hiding behind the flag? Prospects for change in german corporate governance显示文摘 | Simon Peck Winfried Ruigrok | 2000 | European Management Journal2000，，4： | 1 |
| 13 | Anticipation and phynotype in familial intracranial aneurysms 显示文摘 | Ruigrok YM Rinkel GJ Wijmenga C | 2004 | J Neurosurg Psychiatry2004，75，10： | 1 |
| 14 | Influenza A virus polymerase:structural insights into replication and host adaptation mechanisms显示文摘 | Boivin S Cusack S Ruigrok RW | 2010 | J Biol Chem2010，285，28： | 1 |
| 15 | Study design and outcome measures in studies on aneurysmal subarachnoid hemorrhage显示文摘 | Van der Schaaf IC Ruigrok YM Rinkel GJ | 2002 | Stroke2002，33，： | 1 |
| 16 | Protective effect of danshen during myocardial ischemia and reperfusion:an isolated rat heart study显示文摘 | Zhou W Ruigrok TJ | 1990 | Am J Chin Med1990，18，： | 1 |
| 17 | The versican gene and the risk of intracranial aneurysms显示文摘 | Ynte M Ruigrok MD Gabriel JE | 2006 | Stroke2006，，37： | 1 |
| 18 | Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structure显示文摘 | Klumpp K Ruigrok R W Baudin F | 1997 | EMBO J1997，16，6： | 1 |
| 19 | Protective effect of danshen during myocardial ischemia and reperfusion:an isolated rat heart study显示文摘 | Zhou W Ruigrok T J | 1990 | Am J Chin Med1990，18，12： | 1 |
| 20 | The internationalization-performance relationship at Swiss firms: A test of the S-shape and extreme degrees of internationalization显示文摘 | Winfried Ruigrok Wolfgang Amann Hardy Wagner | 2007 | Management International Review2007，，3： | 1 |
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