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| 1 | 影响颅内动脉瘤破裂风险的患者个体特征(英文)显示文摘BACKGROUND AND PURPOSE Knowledge about risk factors contributes to understanding the pathophysiological mechanisms that cause intracranial aneurysm rupture and helps to develop possible treatment strategies.We aimed to study lifestyle and personal characteristics as risk factors for the rupture of intracranial aneurysms.METHODS We performed a case-control study with 250 patients with an aneurysmal subarachnoid hemorrhage and 206 patients with an unruptured intracranial aneurysm.All patients with an aneurysmal subarachnoid hemorrhage and patients with a unruptured intracranial aneurysm were asked to fill in a structured questionnaire about their lifestyle and medical history.For patients with an unruptured intracranial aneurysm,we also collected data on the indication for imaging.With logistic regression analysis,we identified independent risk factors for aneurysmal rupture.RESULTS Reasons for imaging in patients with an unruptured intracranial aneurysm were atherosclerotic disease(23%),positive family history(18%),headache(8%),preventive screening(3%),and other(46%).Factors that increased risk for aneurysmal rupture were smoking(odds ratio,1.9;95% confidence interval,1.2-3.0) and migraine(2.4;1.1-5.1);hypercholesterolemia decreased this risk(0.4;0.2-1.0),whereas a history of hypertension did not independently influence the risk.CONCLUSIONS Smoking,migraine and,inversely,hypercholesterolemia are independent risk factors for aneurysmal rupture.Data from the questionnaire are insufficient to conclude whether hypercholesterolemia or its treatment with statins exerts a risk-reducing effect.The pathophysiological mechanisms through which smoking and migraine increase the risk of aneurysmal rupture should be investigated in further studies.Although a history of hypertension does not increase risk of rupture,a sudden rise in blood pressure might still trigger aneurysmal rupture. | Vlak MH Rinkel GJ Greebe P Algra A | 2013 | 中华神经外科疾病研究杂志2013，12，3： | 17 |
| 2 | Silent stroke in patients with transient isehemie attack or minor isehemie stroke显示文摘 | Hijdra A Algra A | 1992 | Stroke1992，23，9： | 1 |
| 3 | Early circulating levels of endothelial cell activation markers in aneurysmal subarachnoid haemorrhage:associations with cerebral ischaemic events and outcome显示文摘 | Frijns CJ Fijnheer R Algra A | 2006 | J Neurol Neurosurg Psychiatry2006，77，1： | 1 |
| 4 | Impaired glucose tolerance increase stroke risk in nondiabetic patients with transient ischemic attack or minor ischemic stroke显示文摘 | Sarah EV Sandee W Algra A | 2006 | Stroke2006，37，： | 1 |
| 5 | Effectiveness of neurosurgical clip application in patients with aneurismal subarachnoid hemorrhage 显示文摘 | Brilstra EH Algra A Rinkel GJ | 2002 | J Neurosurg2002，97，5： | 1 |
| 6 | Configuration of thecircle of Willis,direction of flow,and shape of the aneurysms asrisk factors for rupture of intracranial aneurysms 显示文摘 | de Rooij NK Velthuis BK Algra A | 2009 | J Neurol2009，256，1： | 1 |
| 7 | Electrocardiographic abnormalities and serum magnesium in patients with sunarachnoid hemorrhage显示文摘 | Van de WA Algra A Rinkel GJ | 2004 | Stroke2004，35，： | 1 |
| 8 | Case-fatality rates and functional outcome after subarachnoid hemorrhage: a systematic review显示文摘 | Hop JW Rinkel GJ Algra A | 1997 | Stroke1997，28，3： | 1 |
| 9 | Cerebral small vessel disease and risk of death, ischemic stroke, and cardiac complications in patients with atherosclerotic disease:the Second Manifestations of ART erial disease-Magnetic Resonance (SMART-MR) study显示文摘 | Conijn MM Kloppenborg RP Algra A | 2011 | Stroke2011，42，： | 1 |
| 10 | Changes in functional outcome and quality of life in patients and earegivers after aneurismal sunarachnoid hemorrhage显示文摘 | Hop J Rinkel G Algra A | 2001 | Journal of Neurosurgery2001，95，： | 1 |
| 11 | Surgical decompression for space-occupying cerebral infarction(the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial):a multicentre,open,randomised trial显示文摘 | Hofmeijer J Kappelle LJ Algra A | 2009 | Lancet Neurol2009，8，4： | 1 |
| 12 | Epilepsy Surgery in tuberous sclerosis: a systematic review 显示文摘 | Jansen FE van Huffelen AC Algra A | 2007 | Epilepsia2007，48，8： | 1 |
| 13 | QT interval variables from 24-Hour electrocardiography and the two Year risk ofsudden death显示文摘 | Algra A Tijssen J G Roelandt J R | 1993 | Br Heart J1993，70，1： | 1 |
| 14 | Antiplatelet drugs in the secondary prevention after stroke:Differential efficacy in large versus small vessel disease/A subgroup analysis from ESPS 22显示文摘 | Ariesen MJ Algra A Kappelle LJ | 2006 | Stroke2006，37，1： | 1 |
| 15 | Paired Twins and{112}Morphology in GaP Nanowires显示文摘 | Algra R E Verheijen M A Feiner L F | 2010 | Nano Letters2010，10，7： | 1 |
| 16 | The position of oxygen adsorbed at the steps of a copper (410) surface studied with low energy ion scattering显示文摘 | Algra A J Suurmeijer E Boers A L | 1983 | Surf Sci1983，128，23： | 1 |
| 17 | Initial loss of consciousness and risk of delyed cerebral ischemia after aneurysmal subarachnoid hemorrhage显示文摘 | Hop JW Rinkel GJ Algra A | 1999 | Stroke1999，30，： | 1 |
| 18 | Case - fatality rate and finetionl outcome after subarachnoid hemorrhage:a systemati cseverity显示文摘 | Hop JW Rinkekel GJ Algra A | 1997 | Stroke1997，28，3： | 1 |
| 19 | Changes in case fatality of anemysmal suharaehnoid haemorrhage over time, according to age, sex, and region: a meta - analysis 显示文摘 | Nieuwkamp DJ Setz LE Algra A | 2009 | Lancet Neurol2009，8，7： | 1 |
| 20 | Cumulative meta - analysis of aspirin ef-ficacy after cerebral ischaemia of arterial origin显示文摘 | ALGRA A VAN GIJN J | 1999 | J Neurol Neu-rosurg Psychiatry1999，66，2： | 1 |
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