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| 1 | Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas:10 year single-center experience and literature review显示文摘AIM:To report our experience with long-term outcomes after multimodal management therapy.METHODS:An observational retrospective study was performed containing seven patients with hepatoblastoma(Hbl)treated in our institution,a tertiary referral center,from 2003 to 2011.Demographic,preoperative,surgical,and outcome variables were collected.A survival analysis and a review of the current literature related to combination neoadjuvant chemotherapy and surgical resection on Hbl were performed.RESULTS:The median age at surgery was 14.4 mo,with a male to female ratio of 4:3.Pretext staging at diagnosis was as follows:stageⅠ,4 cases;stageⅡ,2 patients;and stageⅢ,1 case.Mean pretreatment tumor volume was 735 cm3.Five out of seven patients received neoadjuvant chemotherapy according to SIOPEL-3 or SIOPEL-6 protocols.Tumor volume and alphafetoprotein levels significantly dropped after neoadjuvant therapy.Surgical procedures performed included hemihepatectomies,segmentectomies and atypical resection.All patients received chemotherapy after surgery.Median postoperative hospital stay was 8 d.All patients were alive and disease-free after a median follow-up period of 23 mo.With regards to the literature review,seventeen articles were found that were related to our search.CONCLUSION:Our series shows how multimodal management of Hbl,exhaustive control and a meticulous surgical approach leads to almost 100%complete resection with optimal postoperative results. | Dolores Ayllon Teran Oscar Gómez Beltran Rubén Ciria Bru Elena Mateos González María José Pea Rosa Antonio Luque Molina Pedro López Cillero Javier Briceo Delgado | 2014 | World Journal of Gastroenterology2014，20，29： | 12 |
| 2 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 3 | Anti-porcine circovirus type 2(PCV2) antibody placental barrier leakage from sow to fetus: impact on the diagnosis of intra-uterine PCV2 infection显示文摘Dear Editor,Fetuses develop antibodies when they are infectedwith porcine circovirus type 2(PCV2).At abortion orbirth,both PCV2 and/or anti-PCV2 antibodies can thenbe detected.Finding anti-PCV2 antibodies in aborted fe-tuses or stillborn piglets is generally used as evidence ofan intra-uterine PCV2 infection.However,a recent anal-ysis of fetuses sent in for PCV2 diagnosis and caesare-an-derived,colostrum-deprived pigs revealed that | Dipongkor Saha Rubén Del Pozo Sacristán Nicolaas Van Renne Liping Huang Ruben Decaluwe Annelies Michiels Alfonso Lopez Rodriguez Maria José Rodrí-guez Margarita García Durán Ilse Declerk Dominiek Maes Hans J. Nauwynck | 2014 | Virologica Sinica2014，29，2： | 3 |
| 4 | Oral probiotic VSL #3 attenuates the circulatory disturbances of patients with cirrhosis and ascites显示文摘 | Diego Rincón Javier Vaquero Ana Hernando Evelyn Galindo Cristina Ripoll Marta Puerto Magdalena Salcedo Rubén Francés Ana Matilla María V. Catalina Gerardo Clemente José Such Rafael Ba?ares | 2014 | Liver Int2014，，10： | 2 |
| 5 | Outcomes of a Contemporary Sample of Patients With Atrial Fibrillation Taking Digoxin: Results From the AFBAR Study显示文摘 | Moisés RODRíGUEZ-MA?ERO Fernando OTERO-RAVI?A Javier GARCíA-SEARA Lucrecia ZUGAZA-GURRUCHAGA José M. RODRíGUEZ-GARCíA Rubén BLANCO-RODRíGUEZ Victorino TURRADO TURRADO José M. FERNáNDEZ-VILLAVERDE Rafael C. VIDAL-PéREZ José R. GONZáLEZ-JUANATEY | 2014 | Revista Espa?ola de Cardiología (English Edition)2014，，： | 1 |
| 6 | A review of statistical methods for the evaluation of aquatic habitat suitability for instream flow assessment显示文摘 | AHMADI-NEDUSHAN B ST-HILAIRE A B(E)RUB(E) M | 2006 | River Research and Applications2006，22，5： | 1 |
| 7 | Physicochemical characterization of diesel exhaust particles: Factors for assessing biological activity显示文摘 | Jones T P Williamson B J | 1999 | Atmospheric Environment1999，35，： | 1 |
| 8 | Do collagen meshes offer any benefits over preclude? ePTFE implants in contaminated surgical fields? A comparative in vitro and in vivo study显示文摘 | Rubén García‐Pumarino Gemma Pascual Marta Rodríguez Bárbara Pérez‐K?hler Juan Manuel Bellón | 2014 | J. Biomed. Mater. Res2014，，： | 1 |
| 9 | Simuhaneous removal of acetone and ethanol from aqueous solutions by membrane distillation: prediction using the Fick' s and the exact and approximate Stefan- Maxwell relations显示文摘 | Banat F A A1- Rub F A Shannag M | 1999 | Heat Mass Trans1999，35，5： | 1 |
| 10 | SCA3: Neurological fea- tures, pathogenesis and animal models显示文摘 | Riess O Rub U Pastore A | 2008 | Cerebellum2008，7，2： | 1 |
| 11 | The interaction of guarantees, surplus distribution, and asset allocation in with profit life insurance policies显示文摘 | Kling A Richter A Rub J | 2007 | Insurance: Mathematics and Economics2007，40，1： | 1 |
| 12 | Population PK/PD model of homocysteine concentrations 'alter high-dose methotrexate treatment in patients with acute lymphoblastic leukemia显示文摘 | Rubs H Becker A Drescher A | 2012 | PLoS One2012，7，46： | 1 |
| 13 | A simple evolutionary topology optimization procedure for compliant mechanism design显示文摘 | Rubén Ansola Estrella Veguería Javier Canales José A. Tárrago | 2007 | Finite Elements in Analysis & Design2007，，1： | 1 |
| 14 | Phase and property studies of SiC-BN composites显示文摘 | Rub R Zangvil A Wills R R | 1988 | Adv Ceram Mater1988，3，4： | 1 |
| 15 | Review Diagnosis Methods of Induction Electrical Machines based on Steady State Current显示文摘 | Rub(e)n Puche Panadero Joan Pons Llinares Vicente Climente Alarcon y Manuel Pineda S(a)nchez | 2009 | l lth Spanish Portuguese Conference On Electrical Engineering2009，，： | 1 |
| 16 | Physicochemical characterization of diesel exhaust particles:factors for assessing biological activity显示文摘 | BéruBé K A Jones T P Williamson B J | 1999 | Atmospheric Environment1999，33，10： | 1 |
| 17 | Where does parkinson disease pathology begin in the brain? 显示文摘 | Del Tredici K Rub U De Vos R A | 2002 | J Neuropathol Exp Neurol2002，61，5： | 1 |
| 18 | Determination of perfluorinated compounds in mollusks by matrix solid-phase dispersion and liquid chromatography–tandem mass spectrometry显示文摘 | Eugenia Villaverde-de-Sáa José Benito Quintana Rosario Rodil Raúl Ferrero-Refojos Elisa Rubí Rafael Cela | 2012 | Analytical and Bioanalytical Chemistry2012，，1： | 1 |
| 19 | Vitrification versus slow freezing of oocytes: effects on morphologic appearance, meiotic spindle configuration, and DNA damage显示文摘 | Mónica Martínez-Burgos Leyre Herrero Diego Megías Rubén Salvanes María C. Montoya Ana C. Cobo Juan A. Garcia-Velasco | 2011 | Fertility and Sterility2011，，1： | 1 |
| 20 | Electrical Properties of Boron Nitride Matrix Composites: I, Analysis of McLachlan Equation and Modeling of the Conductivity of Boron Nitride - Boron Carbide and Boron Nitride-Silicon Carbide Composites 显示文摘 | Runyan J Gerhardt R A Rub R | 2001 | Journal of the American Ceramic Society2001，84，7： | 1 |
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