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| 1 | Antihepatoma effect of alpha-fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice显示文摘AIM To evaluate antihepatoma effect ofantisense phosphorothioate oligodeo-xyribonucleotides (S-ODNs) targeted to alpha-fetoprotein (AFP) genes in vitro and in nudemice.METHODS AFP gene expression was examinedby immunocytochemical method or enzyme-linked immunosorbent assay. Effect of S-ODNson SMMC-7721 human hepatoma cell growth invitro was determined using microculturetetrazolium assay. In vivo antitumor activitiesof S-ODNs were monitored by measuring tumorweight differences in treated and control micebearing SMMC-7721 xenografts. Induction of cellapoptosis was evaluated by fluorescence-activated cell sorter (FACS) analysis.RESULTS Antisense S-ODN treatment led toreduced AFP gene expression. Specificantisense S-ODNs, but not control S-ODNs,inhibited the growth of heaptoma cells in vitro.In vivo. only antisense S-ODNs exhibitedobvious antitumor activities. FACS analysisrevealed that the growth inhibition by antisenseS. ODNs was associated with their cell apoptosisinduction.CONCLUSION Antisense S-ODNs targeted toAFP genes inhibit the growth of human hepatomacells and solid hepatoma, which is related totheir cell apoptosis induction. | Xing Wang Wang~1 Jin Hui Yuan~1 Ru Gang Zhang~1 Li Xia Guo~1 Yong Xie~2 Hong Xie~1 ~1Department of Biotherapy,Shanghai Institute of Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China ~2Department of Biology,Hong Kong University of Science and Technology,ChinaDr.Xing Wang Wang earned Ph.D.from Shanghai Institute of Materia Medical,Chinese Academy of Sciences in 1997.Now a professor at Shanghai Institute of Cell Biology,Chinese Academy of Sciences. | 2001 | World Journal of Gastroenterology2001，7，3： | 21 |
| 2 | Growth-inhibiting effects of taxol on human liver cancer in vitro and in nude mice显示文摘AIM To investigate the effects of taxol onSMMC-7721 human hepatoma and itsmechanisms.METHODS In vitro cell growth was assessedby trypan blue exclusion method.Experimentalhepatoma model was established by seedingSMMC-7721 cells subcutaneously into Balb/c(nu/nu)nude mice.In vivo tumor growth wasdetermined by measurement of tumor diameterwith Vernier calipers.The syntheses of DNA,RNA and protein were analyzed by incorporationof ~3H-thymidine,~3H-uridine and ~3H-leucinerespectively.Using light and electronmicroscopes to observe the morphologicalchanges of cells including mitosis andapoptosis.RESULTS Taxol was effective against SMMC-7721 human hepatoma cell growth in the rangesof 2.5 nmol/L-10 nmol/L with mitotic arrestand apoptosis in vitro.DNA,RNA and proteinsyntheses in cells were also obviouslysuppressed by in vitro treatment of taxol for72 h.Taxol at 2.5 nmol/L reduced ~3H-thymidineuptake to about 34% of the control value(P<0.05).Increasing the dose of taxol to20 nmol/L resulted in a greater decrease in ~3H-thymidine incorporation to 60% of the controlvalue(P<0.01).At a concentration of 20 nmol/L,the ~3H-uridine and ~3H-leucine uptakeswere reduced to 52%(P<0.05)and 63%(P<0.01),respectively.In vivo,taxolsignificantly inhibited SMMC-7721 tumor growthat 10 mg/kg,i.p.,once daily for 10 d.A morethan 90% decrease in tumor volume wasobserved by day 11(P<0.01)similarly withmitotic arrest and cell apoptosis.CONCLUSION Taxol has a marked anticanceractivity in SMMC-7721 human hepatoma both invitro and in nude mice.Its mechanisms might beassociated with mitotic arrest,subsequently,apoptosis of the hepatoma cells.No obvioustoxicity was observed with in vivoadministration of taxoi. | Jin Hui Yuan Ru Ping Zhang Ru Gang Zhang Li Xia Guo Xing Wang Wang Dan Luo Yong Xie Hong Xie | 2000 | World Journal of Gastroenterology2000，6，2： | 18 |
| 3 | Stress-mediated p38 activation promotes somatic cell reprogramming显示文摘环境调停压力的改编在生活的进化起必要作用。细胞的改编机制通常包含染色质结构,抄写, mRNA 稳定性和翻译的规定,它最后在基因表示导致有效变化。全球 epigenetic 变化也涉及体的细胞的 reprogramming 进导致的 pluripotent 由定义因素的茎(iPS ) 细胞。这里,我们报导象 hyperosmosis 那样的那个环境压力不仅便于四调停因素的 reprogramming,而且提高二或一导致因素的 iPS 房间代。导致 Hyperosmosis 的 p38 激活在这个过程起一个关键作用。组成的活跃 p38 模仿 hyperosmosis 的积极效果,当主导的否定 p38 和 p38 禁止者堵住 hyperosmosis 的效果时。进一步的学习显示调停压力的 p38 激活可以由减少全球 DNA methylation 水平并且提高 pluripotency 基因的表示支持 reprogramming。我们的结果表明象 hyperosmosis 一样的简单环境应力怎么帮助经由细胞内部的发信号和 epigenetic 调整改变房间的命运。 | Xinxiu Xu Quan Wang Yuan Long Ru Zhang Xiaoyuan Wei Mingzhe Xing Haifeng Gu Xin Xie | 2013 | Cell Research2013，23，1： | 12 |
| 4 | Synthesis and Performance of Polyurethane Coated Urea as Slow/controlled Release Fertilizer显示文摘Polyurethane coated urea slow/controlled release fertilizer was prepared based on urea granules, isocyanate, polyols and paraffin. Isocyanate reacted with polyols to synthesize the polyurethane skin layer on urea granules surface. Paraffin serves as a lubricant during syntheses of polyurethane skin layers. The structure and nutrient release characteristics of the polyurethane skin layers were investigated by FTIR, SEM and TG. Urea nitrogen slow-release behavior of the polyurethane coated urea was tested. The experimental results indicated that compact and dense polyurethane skin layers with a thickness of 10-15 μm were formed on urea surface, the urea nitrogen slow-release time can reach 40-50 days. Paraffin proves to play a key role in inhibiting water to penetrate into urea, but excessive addition would decrease the polyurethane crosslinking density. | 李青山 WU Shu RU Tiejun 王利民 XING Guangzhong WANG Jinming | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，1： | 10 |
| 5 | Using a non-radioisotopic, quantitative TRAP-based method detecting telomerase activities in human hepatoma cells显示文摘A non-radioisotopic, quantitative TRAP-based telomerase activity assay was established mainly by using SYBR Green-I staining instead of radioisotope. Comparing with conventional radioisotope based method, it was better in reproducibility and accuracy. Using this method, we found telomerase activities were absent in normal human liver cells, while detected in ail of four human hepatoma cell lines (BEL-7404, SMMC-7721, QGY-7903 and HCCM) without significant differences. | ZHANG RU GANG XING WANG WANG JIN HUI YUAN LI XIA GUO HONG XIE (Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China) | 2000 | Cell Research2000，10，1： | 8 |
| 6 | Challenges of 22 nm and beyond CMOS technology显示文摘It is predicted that CMOS technology will probably enter into 22 nm node around 2012. Scaling of CMOS logic technology from 32 to 22 nm node meets more critical issues and needs some significant changes of the technology, as well as integration of the advanced processes. This paper will review the key processing technologies which can be potentially integrated into 22 nm and beyond technology nodes, including double patterning technology with high NA water immersion lithography and EUV lithography, new device architectures, high K/metal gate (HK/MG) stack and integration technology, mobility enhancement technologies, source/drain engineering and advanced copper interconnect technology with ultra-low-k process. | HUANG Ru WU HanMing KANG JinFeng XIAO DeYuan SHI XueLong AN Xia TIAN Yu WANG RunSheng ZHANG LiangLiang ZHANG Xing WANG YangYuan | 2009 | Science in China(Series F)2009，52，9： | 8 |
| 7 | Regular Space-like Hypersurfaces in S1^m+1 with Parallel Para-Blaschke Tensors显示文摘In this paper, we give a complete conformal classification of the regular space-like hypersurfaces in the de Sitter Space S_1^(m+1) with parallel para-Blaschke tensors. | Xing Xiao LI Hong Ru SONG | 2017 | Acta Mathematica Sinica,English Series2017，33，10： | 5 |
| 8 | Atomic-scale observation of a two-stage oxidation process in Cu2O显示文摘Cu 2 O nanocrystallines (NC ) 直接被观察由在 situ 高分辨率的传播电子显微镜学。一个二阶段的氧化过程被观察:(1 ) 起始的氧化阶段被 Cu 2 经由稳固固体的转变的 O NC,导致一个新中间的 CuO x 阶段的形成。CuO x 阶段的可能的水晶结构被讨论。(2 ) 随后, CuO x 被 layer-by-layer 氧化转变成 CuO。这些结果将在理解铜氧化物的氧化机制帮助并且为改进他们的结构的差异并且利用他们的潜在的工业应用铺平道路。 | Huihui Liu He Zheng Lei Li Huaping Sheng Shuangfeng Jia Fan Cao Xi Liu Boyun Chen Ru Xing Dongshan Zhao Jianbo Wang | 2017 | Nano Research2017，10，7： | 4 |
| 9 | Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells显示文摘Telomerase activity was inhibited in a dose and time-dependent manner with the treatment of cisplatin for 24, 48, or 72 h in a concentration ranged from 0.8 to 50 1uM in BEL-7404 human hepatoma cells. There were no changes in expression pattern of three telomerase subunits, its catalytic reverse transcriptase subunit (hTERT), its RNA component (hTR) or the associated protein subunit (TP1), after cisplatin treated for 72 h with indicated concentrations. Mean telomere lengths were decreased by the cisplatin treatment. Cell growth inhibition and cell cycle accumulation in G2/M phase were found to be correlated with telomerase inhibition in the present study, but percentages of cell apoptosis did not change markedly during the process. | Ru GANG ZHANG, Ru PING ZHANG, XING WANG WANG, HONG XIE Department of Biotherapy, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 200031, China | 2002 | Cell Research2002，12，1： | 3 |
| 10 | Association between Hypertension with Hyperhomocysteinemia and Cognitive Impairment in the Kailuan Community of China:A Cross-sectional Study显示文摘Cognitive impairment,especially dementia,is common in elderly individuals and seriously affects life quality.Dementia is the most severe expression of cognitive impairment characterized by a progressive functional decline in one or more cognitive domains.The prevalence of dementia has increased dramatically,and the number of patients with dementia will reach 130 million in 2050.The worldwide prevalence of dementia among elderly individuals is approximately 5.0%.In China,more than 220 million people aged over 60 years in 2016. | CHEN Xue Yu YANG Yao TANG Zhao Yang LYU Jian SHI Feng Xue CHEN Yan Ru WANG Xiao Hui TAN Tan XING Wei Jia HOU Hai Feng JI Long LI Xiao Dong LI Dong | 2021 | Biomedical and Environmental Sciences2021，34，7： | 3 |
| 11 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 12 | Effect of long-term fertilization on soil nitrate distribution显示文摘A thirteen years long term field fertilizer experiment was conducted to monitor the effect of different fertilization on soil nitrate distribution. The results showed: (1) Applying relative excessive N fertilizer could result large quantities of NO - 3 residue and NO - 3 movement downward in soil profiles; amending phosphate fertilizer or organic manure with nitrogen fertilizer together could significantly improve the status of NO - 3 leaching downward due to the balanced uptake of nutrients by crops. (2) Appropriate amounts of nitrogen fertilizer which was equal or smaller than the optimal fertilization rate could not result in more NO - 3 leaching in Northern China. (3) Precipitation influenced the amounts and depth of soil NO\+-\-3 leaching: NO - 3 could move to 80 cm depth or below at autumn or at the next spring when rainfall was higher during the rainy season through July to September in North China. | GUO Li ping *, ZHANG Fu suo, WANG Xing ren, MAO Da ru, CHEN Xin ping (Department of Plant Nutrition, China Agricultural University, Beijing 100094, China. E mail: guolp@ns.ami.ac.cn) | 2001 | Journal of Environmental Sciences2001，13，1： | 3 |
| 13 | Theory and verification of operator design methodology显示文摘Non-recurring-engineering(NRE)and time-to-market play an increasingly important role in the field of IC design.Meanwhile,with the continuous development of IC manufacturing technology,it is necessary to propose a novel design methodology to shorten design cycle and enhance design efficiency.In this paper,operator design methodology(ODM)is presented and an H.264 encoder is implemented as a verification.According to the flow of ODM,the register transfer level(RTL)design of H.264 encoder has been accomplished with 15 man-months,which is lower than the average 19 man-months in the field of traditional application specific integrated circuit(ASIC)design.Moreover,with the advantage of operator design library,the design has a comparable performance with other ASIC implementations.The obtained design can support a real-time video encoding of 720p at 60 frames per second or 1080p at 30 frames per second,working at 167 MHz with SMIC 0.13 μm CMOS technology.These results provide good evidence for the practicability and efficiency of ODM. | HU Ziyi ZHAO Yong WANG XinAn HUANG Ru WANG Teng ZHANG Xing | 2012 | Science China(Information Sciences)2012，55，2： | 3 |
| 14 | Deep insight into the voltage amplification effect from ferroelectric negative capacitance显示文摘Dear editor, Power dissipation has become one of the most serious problems for nano-electronics. For conventional transistors, the operation voltage cannot be continuously reduced due to the fundamental limitation of sub threshold swing (SS)(60 mV / decade at room temperature)[1,2]. The voltage amplification (VA) induced by the negative capacitance (NC) effect of ferroelectrie (FE) material provides a possible approach for FE-based transistors to achieve sub-60 SS charactetistics [3]. However, the physical origin of NC effect in FE-FET are still unclear and controversial. | Huimin WANG Qianqian HUANG Mengxuan YANG Xing ZHANG Ru HUANG | 2019 | Science China(Information Sciences)2019，62，8： | 2 |
| 15 | Novel vertical channel double gate structures for high density and low power flash memory applications显示文摘The flash memory technology meets physical and technical obstacles in further scaling. New structures and new materials are implemented as possible solutions. This paper focuses on two kinds of new flash cells for high density and low power memory applications based on the vertical channel double gate structure. The proposed VD-NROM with dual-nitride-trapping-layer and vertical structure can achieve four-bit-per-cell storage capability. And the proposed VSAS-FG cell benefits the high programming efficiency, low power and high density capability, which can be realized without any additional mask and can achieve the self-alignment of the split-gate channel and the floating-gate. The two novel flash cell structures can be considered as potential candidates for different flash memory applications. | HUANG Ru ZHOU FaLong CAI YiMao WU DaKe ZHANG Xing | 2008 | Science in China(Series F)2008，51，6： | 2 |
| 16 | FORWARD GATED-DIODE R-G CURRENT METHOD: A SIMPLE NOVEL TECHNIQUE FOR CHARACTERIZING LATERAL LIGHTLY DOPING REGION OF LDD MOSFET's显示文摘This paper presents a simple novel technique-forward gated-diode R-G current method-to determine the lateral lightly-doped source/drain (S/D) region interface state density and effective surface doping concentration of the lightly-doped drain (LDD) N- MOSFET's simultaneously. One interesting result of the numerical analysis is the direct characterization of the interface state density and characteristic gate voltage values corresponding to LDD effective surface doping concentration. It is observed that the S/D N- surface doping concentration and corresponding region's interface state density are R-G current peak position and amplitude dependent, respectively. It is convincible that the proposed method is well suitable for the characterization of deep sub-micron MOSFET's in the current ULSI technology. | He Jin Huang Aihua Zhang Xing Huang Ru Wang Yangyuan(institute of Micro-electronics, Peking University, Beijing 100871) | 2001 | Journal of Electronics(China)2001，18，2： | 2 |
| 17 | THE COLOUR REACTION OF CADMIUM WITH 1-(2-BENZOTIIIAZOLYL)-3-(4-PHENYLAZOPHENYL)-TRIAZENE AND ITS APPLICATION显示文摘THE COLOUR REACTION OF CADMIUM WITH 1-(2-BENZOTIIIAZOLYL)-3-(4-PHENYLAZOPHENYL)-TRIAZENE AND ITS APPLICATIONTHECOLOURREACTION... | Chu Ru GONG Zhi Gang SHE Hao Xing XU Bin XU(Department of Chemistry, Hubei Normal University,Huangshi 435002) | 1995 | Chinese Chemical Letters1995，6，9： | 2 |
| 18 | Synthesis and anti-TMV activity of novel N-(pyrimidin-5-yl)-N'-phenylureas显示文摘In order to find novel leading structures of pesticide,a series of N-(pyrimidin-5-yl)-N'-phenylureas(4a-4h) were designed and synthesized from 4-chloro-2-diethylamino-6-methyl-5-nitropyrimidine 1 via substitution,reduction and acylation procedures. Preliminary bioassay showed that all the target compounds processing good anti-TMV(tobacco mosaic virus) activity.Two compounds(4d and 4e) displayed higher activity superior to virazole at a concentration of 5.0×10^(-4)g/mL. | De Kai Yuan Da Qiang Zhang Ru Xing Li Dao Quan Wang Xin Ling Yang | 2011 | Chinese Chemical Letters2011，22，1： | 2 |
| 19 | Weighted Integral Inequalities for Solutions of the - Harmonic Equation 显示文摘 | XING Yu - ruing | 2003 | J Math Anal App12003，279，： | 1 |
| 20 | Genetic analysis,molecular tagging and mapping of the thermo-sensitive genic male-sterile gene ( wtms 1 ) in wheat 显示文摘 | XING Q H RU Z G ZHOU C J | 2003 | Theor Appl Genet2003，107，： | 1 |
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