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| 1 | Synthesis of tetrazole containing 1,2,3-thiadiazole derivatives via U-4CR and their anti-TMV activity显示文摘A series of novel tetrazole containing 1,2,3-thiadiazole derivatives were designed and synthesized via Ugi reaction. Their structures were confrmed by melting points, IR,1H NMR, and HRMS(ESI).Preliminary bioassay indicated that most target compounds exhibited very good direct anti-TMV activity at 100 μg/mL, which was equal to or higher than that of ribavirin. Among them, compounds 4b, 4c and 4i also showed equivalent protection effect to ribavirin in vivo at 100μg/mL. | Shou-Xin Wanga Zhen Fang Zhi-Jin Fan Dun Wang Yue-Dong Li Xiao-Tian Ji Xue-Wen Hua Yun Huang Tatiana A.Kalinina Vasiliy A.Bakulev Yury Yu.Morzherin | 2013 | Chinese Chemical Letters2013，24，10： | 3 |
| 2 | 基于结构多样化衍生的抗植物病毒药剂研究进展显示文摘植物病毒病是一种发生在作物上的毁灭性病害,严重威胁农业的发展。基于对植物病毒病的防治,科研工作者在新型抗植物病毒剂的研究创制方面进行了大量的研究。根据化合物的结构特点进行分类,总结了近10年中国新型抗植物病毒剂的创制研究取得的成果,并对发展前景进行展望。 | 姚键梅 蒲璐璐 饶家瑞 王敏 郭灿 雷志伟 | 2021 | 农药2021，60，12： | 1 |
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