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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Autophagy in mammalian cells显示文摘Autophagy is a regulated process for the degradation of cellular components that has been well conserved in eukaryotic cells. The discovery of autophagy-regulating proteins in yeast has been important in understanding this process. Although many parallels exist between fungi and mammals in the regulation and execution of autophagy, there are some important differences. The preautophagosomal structure found in yeast has not been identified in mammals, and it seems that there may be multiple origins for autophagosomes, including endoplasmic reticulum, plasma membrane and mitochondrial outer membrane. The maturation of the phagophore is largely dependent on 5'-AMP activated protein kinase and other factors that lead to the dephosphorylation of mammalian target of rapamycin. Once the process is initiated, the mammalian phagophore elongates and matures into an autophagosome by processes that are similar to those in yeast. Cargo selection is dependent on the ubiquitin conjugation of protein aggregates and organelles and recognition of these conjugates by autophagosomal receptors. Lysosomal degradation of cargo produces metabolites that can be recycled during stress. Autophagy is an impor-tant cellular safeguard during starvation in all eukaryotes; however, it may have more complicated, tissue specific roles in mammals. With certain exceptions, autophagy seems to be cytoprotective, and defects in the process have been associated with human disease. | Kadija Abounit Tiziano M Scarabelli Roy B McCauley | 2012 | World Journal of Biological Chemistry2012，3，1： | 18 |
| 3 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 4 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 5 | Fever as the only manifestation of hypersensitivity reactions associated with oxaliplatin in a patient with colorectal cancer Oxaliplatin-induced hypersensitivity reaction显示文摘Hypersensitivity reactions (HSR) to oxaliplatin in patients with colorectal cancer include facial ushing, erythema, pruritis, fever, tachycardia, dyspnea, tongue swelling, rash/hives, headache, chills, weakness, vomiting, burning sensations, dizziness, and edema. We report a patient with fever as the sole manifestation of initial HSR, review the literature and discuss the management of HSR. A 57-year-old female with T3N2M0 rectal adenocarcinoma received modified FOLFOX-6. She tolerated the first 8 cycles without any toxicities except grade 1 peripheral neuropathy and nausea. During 9th and 10th infusions, she developed fever to a maximum of 38.3℃ with stable hemodynamic status despite medications. During 11th infusion, she developed grade 3 HSR consisting of symptomatic bronchospasm, hypotension, nausea, vomiting, cough, and fever. On examination, she was pale, cyanotic, with a temperature of 38.8℃, BP dropped to 95/43 mm Hg, pulse of 116/min and O2 saturation of 88%-91%. She was hospitalized for management and recovered in 24 h. Fever alone is not a usual symptom of oxaliplatin HSR. It may be indicative that the patient may develop serious reactions subsequently, as did our patient who developed hypotension with the third challenge. Treatment and prevention consists of slowing the infusion rate, use of steroids and antagonists of Type 1 and 2 histamine receptor antagonists, whereas desensitization could help to provide the small number of patients who experience severe HSR with the ability to further receive an effective therapy for their colorectal cancer. | M Wasif Saif Shailja Roy Leslie Ledbetter Jennifer Madison Kostas Syrigos | 2007 | World Journal of Gastroenterology2007，13，39： | 4 |
| 6 | International Consensus Statement on surveillance and management of dysplasia in inflammatory bowel disease显示文摘 | Loren Laine Tonya Kaltenbach Alan Barkun Kenneth R. McQuaid Venkataraman Subramanian Roy Soetikno James E. East Francis A. Farraye Brian Feagan John Ioannidis Ralf Kiesslich Michael Krier Takayuki Matsumoto Robert P. McCabe Klaus M?nkemüller Robert Odze M | 2014 | Gastrointestinal Endoscopy2014，，： | 3 |
| 7 | 爱尔兰海岸夏季空气颗粒物水溶性离子粒径分布研究显示文摘研究了爱尔兰西海岸国际海洋大气研究站夏季(2002年8月12~22日)大西洋气团颗粒物中水溶性无机离子的含量与其粒径关系.海盐成分(Cl-、SO42-、Na+、Ca2+、Mg2+、K+)含量在粗颗粒物中随粒径呈双峰分布(0.8~30 μm),但Ca2+和K+受陆域源影响,在亚微米颗粒区间出现另一分布峰(0.1~0.8 μm).二次颗粒物成分在所有颗粒物中均有检出;NO3-呈广域宽带分布,其中大部分出现在海盐主峰区(0.8~8 μm,存在Dp 1.4 μm和Dp 4.4 μm两种模态);nss-SO42-(非海盐硫酸根)和NH4+呈相关三峰分布(Dp 0.44 μm、Dp 1.4 μm和Dp 4.4 μm),CH3SO3-也呈相似三峰分布(Dp 0.44 μm、Dp 1.4 μm和Dp 8 μm),三者在亚微米颗粒区间同位出现主峰.二次颗粒物成分Dp 1.4 μm模态在海岸空气颗粒物研究文献中尚少见报道.讨论了亚微米区间二次颗粒物盐类的化学形态.TSP中nss-SO42-、NO3-、NH4+和CH3SO3-的日均浓度分别为0.279、0.171、0.158和0.041 μg/m3. | 黄卓尔 Roy M Harrison 殷建新 | 2005 | 海洋环境科学2005，24，4： | 3 |
| 8 | Atmospheric pressure gliding arc discharge plasma treatments for improving germination, growth and yield of wheat显示文摘Wheat(Triticum aestivum) seeds were treated with atmospheric pressure gliding arc discharge plasmas to investigate the effects on water absorption, seed germination rate, seedling growth and yield in wheat. The surface architectures and functionalities of the seeds were found to modify due to plasma treatments. 6 min treatment was provided 95%–100% germination rate.For the treatment duration of 3 and 9 min the growth activity, dry matter accumulation, leaves chlorophyll contents, longest spikes, number of spikes/spikelet and total soluble protein content in shoots were improved. The grain yield of wheat was increased ~20% by 6 min treatment with H_2O/O_2 plasma with respect to control. | N C ROY M M HASAN A H KABIR M A REZA M R TALUKDER A N CHOWDHURY | 2018 | Plasma Science and Technology2018，20，11： | 2 |
| 9 | Narrow band imaging to differentiate neoplastic and non-neoplastic colorectal polyps in real time: a meta-analysis of diagnostic operating characteristics显示文摘 | Sarah K McGill Evangelos Evangelou John P A Ioannidis Roy M Soetikno Tonya Kaltenbach | 2013 | Gut2013，，12： | 2 |
| 10 | Expression of human gelatinase B in Pichia pastoris显示文摘 | Roy N Padmanabhan S Smith M | 1999 | Protein Expression Purefication1999，16，： | 2 |
| 11 | 持续血糖监测用于检测危重症患儿高血糖的前瞻性研完显示文摘目的用组织间隙持续血糖监测仪评价PICU非糖尿病患儿血糖增高程度,并与实验室间断检测血糖的方法比较,评价监测效果。设计前瞻性、观察性研究。场所西马萨诸塞州一所医学中心拥有10张床位的PICU。对象20名非糖尿病患儿,年龄1~18岁,预计需要2d以上的重症监护。干预在患儿皮下放置持续血糖监测仪,征得患儿及家属同意后,另接探头进行72h连续血糖监测并与实验室所测血糖水平进行比较。测量指标和主要结果平均每位患儿持续监测685.2h,共有16337次探头读数,43.0%读数高于125mg/dl(6.9mmol/L),27.2%高于140mg/dl(7.8mmol/L),4%高于200mg/dl(11.1mmol/L)。实验室血糖值提示升高的频度不如持续监测,且易错过血糖升高的关键时段。结论PICU患儿可出现显著血糖升高,实验室间断检测血糖可能低估此现象。 | Allen HF Rake A Roy M | 2008 | 中国小儿急救医学2008，15，2： | 2 |
| 12 | Filamentation “remote” sensing of chemical and biological agents/pollutants using only one femtosecond laser source显示文摘 | S. L. Chin H. L. Xu Q. Luo F. Théberge W. Liu J. F. Daigle Y. Kamali P. T. Simard J. Bernhardt S. A. Hosseini M. Sharifi G. Méjean A. Azarm C. Marceau O. Kosareva V. P. Kandidov N. Ak?zbek A. Becker G. Roy P. Mathieu J. R. Simard M. Chateauneuf J. Dubois | 2009 | Applied Physics B2009，，1： | 2 |
| 13 | Identification of a sequence in human Toll-like receptors 5 required for the binding of Gram-negative flagellin显示文摘 | Sleven B M Pillip W Roy R H | 2003 | J Biol Chemistry2003，278，23： | 1 |
| 14 | E1A- induced processing of procaspase - 8 can occur independently of FADD and is inhibited by Bcl-2显示文摘 | Nguyen M Branton PE Roy S | 1998 | J Biol Chem1998，273，33： | 1 |
| 15 | Growth of bifidobacteria and their enzyme profiles显示文摘 | DESJARDINS M L ROY D | 1990 | Dairy Sci1990，73，： | 1 |
| 16 | Pilot study and protocol of the Canadian trial of atrial fibrillation (CTAF)显示文摘 | TALAJIC M THIBAULT B | 1997 | Am J Cardiol1997，80，4： | 1 |
| 17 | tion of Euler/Navier-Stokes codes using the method of manufactured solutions显示文摘 | Roy C J Nelson C C Smith T M | 2004 | Int J Numer eth Fluids2004，44，： | 1 |
| 18 | Diagnosis and management of cervical cancer 显示文摘 | Petignat P Roy M | 2007 | BMJ2007，335，7623： | 1 |
| 19 | A mechanistic approach for modulation of arsenic toxicity in human lymphocytes by curcumin,an active constituent of medicinal herb curcuma longa linn显示文摘 | Mukherjee S Roy M Dey S | 2007 | J Clin Biochem Nutr2007，41，1： | 1 |
| 20 | Parametric optimization and performance analysis of a waste heat recovery system using Organic Rankine Cycle 显示文摘 | Roy J P Mishra M K Misra A | 2010 | Energy2010，35，12： | 1 |
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