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| 1 | Molecular therapy for hepatic injury and fibrosis:Where are we?显示文摘肝的纤维变性是弯屈的愈合的回答,包含发炎和纤维发生的小径。响应各种各样的侮辱,例如酒精,局部缺血,病毒的代理人,和药或肝毒素, hepatocyte 损坏将在肝由 Kupffer 房间和另外的房间类型引起 cytokines 和另外的可溶的因素的版本。这些因素导致肝的星形细胞的激活,它综合大量细胞外的矩阵部件。与长期的损害和纤维变性,肝建筑学和新陈代谢被破坏,最后作为肝硬化和它的复杂并发症表明。除了消除病原学,例如抗病毒的治疗和药理学干预,新奇策略正在被开发直接在细胞的潜水艇和分子的层次探讨肝的损害和纤维变性,这令人鼓舞。与在理解这些机制和小径的改进,在损害给步调音,发信号,激活,和基因表示被分子的形式和分子的其它或基因治疗途径正在指向。这篇文章打算为肝的损害和纤维变性以分子的治疗的当前的地位提供更改并且我们多远从这些新治疗学的形式的临床的利用。 | Colette C Prosser Roy D Yen Jan Wu | 2006 | World Journal of Gastroenterology2006，12，4： | 41 |
| 2 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 3 | The use of psychotropic drugs in irritable bowel syndrome显示文摘 | Roy Dekel Douglas A Drossman Ami D Sperber | 2013 | Expert Opinion on Investigational Drugs2013，，3： | 4 |
| 4 | Heat stroke induced cerebellar dysfunction:A “forgotten syndrome”显示文摘We report a case of heat stroke induced acute cerebellar dysfunction, a rare neurological disease characterized by gross cerebellar dysfunction with no acute radiographic changes, in a 61 years old ship captain presenting with slurred speech and gait ataxia. A systematic review of the literature on heat stroke induced cerebellar dysfunction was performed, with a focus on investigations, treatment and outcomes. After review of the literature and detailed patient investigation it was concluded that this patient suffered heat stroke at a temperature less than that quoted in the literature. | Athula D Kosgallana Shreyashee Mallik Vishal Patel Roy G Beran | 2013 | World Journal of Clinical Cases2013，1，8： | 2 |
| 5 | Designer probiotics: Development and applications in gastrointestinal health显示文摘Given the increasing commercial and clinical relevance of probiotics, improving their stress tolerance profile and ability to overcome the physiochemical defences of the host is an important biological goal. Herein, I review the current state of the art in the design of engineered probiotic cultures, with a specific focus on their utility as therapeutics for the developing world; from the treatment of chronic and acute enteric infections, andtheir associated diarrhoeal complexes, to targeting HIV and application as novel mucosal vaccine delivery vehicles. | Roy D Sleator | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，3： | 2 |
| 6 | Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013显示文摘 | Joseph R. Mikhael David Dingli Vivek Roy Craig B. Reeder Francis K. Buadi Suzanne R. Hayman Angela Dispenzieri Rafael Fonseca Taimur Sher Robert A. Kyle Yi Lin Stephen J. Russell Shaji Kumar P. Leif Bergsagel Steven R. Zeldenrust Nelson Leung Matthew T. D | 2013 | Mayo Clinic Proceedings2013，，4： | 2 |
| 7 | Clinical outcomes of pregnancy in women with type 1 diabetes 1 1 The Northern Regional Maternity Survey Office kindly provided corroborative data on congenital abnormalities.显示文摘 | Roy Taylor Choy Lee D Kyne-Grzebalski S.M Marshall J.M Davison | 2002 | Obstetrics & Gynecology2002，，4： | 2 |
| 8 | Properties of amorphous diamond films prepared by a filtered cathodic arc显示文摘 | Lossy R Pappas D L Roy R A | 1994 | J Appl Physics1994，75，： | 2 |
| 9 | Safety First and the Holding of Assets 显示文摘 | Roy A D | 1952 | Econometrics1952，20，3： | 1 |
| 10 | Role of 'ischemia modified albumin', a new biochemical marker of myocardial ischaemia in the early diagnosis of acute coronary syndromes 显示文摘 | Sinha MK Roy D Gaze DC | 2004 | Emerg Med J2004，21，1： | 1 |
| 11 | A Review of Life Cycle Assessment ( LCA) on Some Food Products 显示文摘 | Roy P Nei D Orikasa T | 2009 | Journal of Food Engineering2009，90，1： | 1 |
| 12 | Growth of bifidobacteria and their enzyme profiles显示文摘 | DESJARDINS M L ROY D | 1990 | Dairy Sci1990，73，： | 1 |
| 13 | Pilot study and protocol of the Canadian trial of atrial fibrillation (CTAF)显示文摘 | TALAJIC M THIBAULT B | 1997 | Am J Cardiol1997，80，4： | 1 |
| 14 | A comparative study of markers of inflammation for the assessment of cardiovascular risk in patients presenting to the emergency department with acute chest pain suggestive of acute coronary syndrome显示文摘 | Roy D Quiles J Avanzas P | 2006 | Int J Cardiol2006，109，2： | 1 |
| 15 | Ischemia Modified Albumin for the assessment of patients presenting to the emergency department with acute chest pain but non-diagnostic 12-lead electrocardiograms and negative cardiac troponin T 显示文摘 | Roy D Quiles J Aldama G | 2004 | Int J Cardiol2004，97，： | 1 |
| 16 | Role of'Isehemia modified albumin',a new biochemical marker of myocardial ischemia,in the early diagnosis of acute coronary syndromes显示文摘 | Sinha MK Roy D Gaze DC | 2004 | Emerg Med J2004，21，1： | 1 |
| 17 | Evaluation of the California mastitls test as a precalving treatment selection tool for Holstein heifers显示文摘 | Roy J P Du Tremblay D Descoteaux L | 2009 | Vet Microbiol2009，134，12： | 1 |
| 18 | Antisense oligonucleotide targeting the transforming growth factor β1 increases expression of specific genes and functions of Leydig cells显示文摘 | Roy CL Leduque P Li JY Seaz JM Langlois D | 1998 | Eur J Biochem1998，257，2： | 1 |
| 19 | Endovascular treatment of acutely ruptured and unruptured aneurysms of the basilar bifurcation显示文摘 | Raymond J Roy D Bojanowski M | 1997 | J Neurosurg1997，86，： | 1 |
| 20 | Prognostic value of D-dimer in patients with pulmonary embolism显示文摘 | Aujesky D Roy PM Guy M | 2006 | Thromb Haemost2006，96，4： | 1 |
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