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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 3 | Localization of mrna for vascular endothelial growth factor (Vegf), angio- poietins and their receptors during the peri-implanta- tion period and early pregnancy in marmosets (Cal- lithrix Jacchus) 显示文摘 | Rowe A J Wulff C Fraser H M | 2003 | Reproduction2003，126，2： | 1 |
| 4 | Modified M2 proteins produce heterotypic immunity against influenza A virus显示文摘 | Frace A M Klimov A I Rowe T | 1999 | Vaccine1999，17，： | 1 |
| 5 | Weak, strong, and strong cyclic planning via symbolic model eheeking显示文摘 | Cimatti A Pistore M Rowed M | 2003 | Artificial Intelli- gence2003，147，12： | 1 |
| 6 | Modified M2 proteins produce heterotypic immunity against influenza A virus显示文摘 | Frace A M Klimov A I Rowe T | 1999 | Vaccine1999，17，18： | 1 |
| 7 | Electrical transport properties of SnBi4Te7 and PbBi4Te7 with different deviations from stoichiometry显示文摘 | Kuznetsov V L Kuznetsova L A ROWE D M | | 0，，： | 1 |
| 8 | Neural correlates of passive and active encoding and retrieval: A 3T fMRI study显示文摘 | Dove A Rowe JB Brett M | 2001 | Neuroim- age2001，13，6： | 1 |
| 9 | Optimism, coping, and long-term recovery from coronary artery surgery in women显示文摘 | King K B Rowe M A Kimble L P | 1998 | Res Nuts Health1998，21，1： | 1 |
| 10 | Value Orientations, Awareness of Consequences, and Participation in a Whale Watching Education Program in Oregon 显示文摘 | Christensen A Rowe S Needham M D | 2007 | Human Dimensions of Wildlife2007，12，4： | 1 |
| 11 | Synthesis of surface-initiated stimuli-responsive diblock eopolymer brushes utilizing a combination of ATRP and RAFT polymerization techniques显示文摘 | Rowe M A Hammer B A G Boyes S G | 2008 | Macromolecules2008，41，12： | 1 |
| 12 | Molecular cloning of polyoma virus DNA in Escherichia coli: plasmid vector system显示文摘 | Israel M A Chan H W Rowe W P | 1979 | Science1979，203，4383： | 1 |
| 13 | Is the current BMI obesity classification appropriate for black and white post- menopausal women? 显示文摘 | EVANS E M ROWE D A GACETTE S B etal | 2006 | Int J Obes (Lond)2006，30，5： | 1 |
| 14 | High-temperature refractory metal-intermetallic composites显示文摘 | JACKSON M R BEWLAY B P ROWE R G SKELLY D W LIPSITT H A | 1996 | JOM1996，48，1： | 1 |
| 15 | Air-water exchange of polychlorinated biphenyls in the Delaware River 显示文摘 | Rowe A Totten L Xie M G | 2004 | Environ Sci Technol2004，41，4： | 1 |
| 16 | MBE growth and properties of ZnO on sapphire and SiC substrates 显示文摘 | Johnson M A L Fujita S Row landW H J | | Electron Mater0，25，5： | 1 |
| 17 | Gamma knife radiosurgery for cerebral arteriovenous malformations显示文摘 | Kemeny A A Radatz M W Rowe J G | 2004 | Acta Neurochir Suppl2004，91，： | 1 |
| 18 | Exploiting temperature dependency in the detection of NQR signals显示文摘 | JAKOBSSON A MOSSBERG M ROWE M D | 2006 | IEEE Transactions on Signal Processing2006，54，5： | 1 |
| 19 | Robust detection of stochastic nuclear quadrupole resonance signals 显示文摘 | SOMASUNDARAM S D JAKOBSSON A ROWE M D | 2008 | IEEE Transactions on Signal Processing2008，56，9： | 1 |
| 20 | Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia显示文摘 | DiNardo C D Propert K J Loren A W Paietta E Sun Z X Levine R L Straley K S Yen K Patel J P Agresta S Abdel-Wahab O Perl A E Litzow M R Rowe J M Lazarus H M Fernandez H F Margolis D J Tallman M S Luger S M Carroll M | 2012 | Blood2012，121，24： | 1 |
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