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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 3 | 新灭鼠剂杀它仗对小家鼠的围栏和现场试验显示文摘灭鼠剂的实验室研究,目前主攻方向是寻找能够克服杀鼠灵(Warfarin)等第一代抗凝血灭鼠剂抗药性有价值的化合物。主要成果是已经评价了鼠得克(Difenacoun)、溴敌隆(Bromadiolone)和大隆(Brodifacoum)对家栖鼠和其他害鼠的效果。围栏群养鼠摄食试验和现场试验结果证明,上述三种化合物防制抗杀鼠灵小家鼠(Mus mus- | Rowe FP Bradfield A Swinny T 董天义 | 1989 | 中国鼠类防制杂志1989，5，1： | 2 |
| 4 | Mathematical modeling of proton membrane fuel cells显示文摘 | Rowe A Li Xianguo | 2001 | Power Source2001，102，： | 2 |
| 5 | Dray force in a hydraulic model of a fluidized bed partl显示文摘 | ROWE P N HENWOOD G A | 1961 | Trunsinst Chem Engrs1961，39，1： | 1 |
| 6 | Comparison of video shot boundary detection techniques 显示文摘 | Boreczky J S Rowe L A | 1996 | Journal of Elec- tronic Imaging1996，5，2： | 1 |
| 7 | A preliminary quantitative study of particle segregation in gas fluidized beds-binary systems of near sphericalparticles显示文摘 | Rowe P N Nienow A W | 1972 | Trans Instn Chem Engrs1972，50，4： | 1 |
| 8 | Localization of mrna for vascular endothelial growth factor (Vegf), angio- poietins and their receptors during the peri-implanta- tion period and early pregnancy in marmosets (Cal- lithrix Jacchus) 显示文摘 | Rowe A J Wulff C Fraser H M | 2003 | Reproduction2003，126，2： | 1 |
| 9 | Production and processing of milk from transgenic goats expressing human lysozyme in the mammary gland 显示文摘 | MAGA E A SHOEMAKER C F ROWE J D | 2006 | Journal of Dairy Science2006，89，2： | 1 |
| 10 | Particle segregation in fluidized binary mixtures显示文摘 | Nienow A W Rowe P N Chiba T | 1978 | AIChE Symp Ser1978，74，176： | 1 |
| 11 | Effects of dietary sodium bicarbonate and calcium chloride on physiological responses of lactating dairy cows in hot weather显示文摘 | ESCOBASA A COPPOCK C E ROWE L D | 1984 | Dairy Sci1984，67，： | 1 |
| 12 | Sequen- tial microarray to identify timing of molecular respon- ses to Haemonchus contortus infection in sheep显示文摘 | ROWE A GONDRO C EMERY D | 2009 | Vet Parasitol2009，161，12： | 1 |
| 13 | Modified M2 proteins produce heterotypic immunity against influenza A virus显示文摘 | Frace A M Klimov A I Rowe T | 1999 | Vaccine1999，17，： | 1 |
| 14 | Forensic paleontology: The Archaeoraptor forgery显示文摘 | Rowe T Ketcham R A Denison C | 2001 | Nature2001，410，： | 1 |
| 15 | Avoidance of Thermal Damage in Grinding and Prediction of the Damage Threshold显示文摘 | ROWE W B PETTIT J A BOYLE | 1988 | Annals of the CIRP1988，37，1： | 1 |
| 16 | Ultrahigh-vacuum studies of enhanced Raman scattering from pyridine on Ag surfaces显示文摘 | Rowe J E Shank C V Zwemer D A | 1980 | Phys Rev Lett1980，44，： | 1 |
| 17 | A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion显示文摘 | Rowe C L Connolly S A Chen J Jardetzky T S Longnecker R | 2013 | Virology2013，436，1： | 1 |
| 18 | Weak, strong, and strong cyclic planning via symbolic model eheeking显示文摘 | Cimatti A Pistore M Rowed M | 2003 | Artificial Intelli- gence2003，147，12： | 1 |
| 19 | Mathematical modeling of proton exchange membrane fuel cells显示文摘 | ROWE A LI Xian-guo | 2001 | Power Sources2001，102，1： | 1 |
| 20 | Modified M2 proteins produce heterotypic immunity against influenza A virus显示文摘 | Frace A M Klimov A I Rowe T | 1999 | Vaccine1999，17，18： | 1 |
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