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| 1 | A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia显示文摘AIM:To compare iron depletion to lifestyle changes alone in patients with severe nonalcoholic fatty liver disease(NAFLD)and hyperferritinemia,a frequent feature associated with more severe liver damage,despite at least 6 mo of lifestyle changes.METHODS:Eligible subjects had to be 18-75 years old who underwent liver biopsy for ultrasonographically detected liver steatosis and hyperferritinemia,ferritin levels≥250 ng/mL,and NAFLD activity score>1.Iron depletion had to be achieved by removing 350 cc of blood every 10-15 d according to baseline hemoglobin values and venesection tolerance,until ferritin<30 ng/mL and/or transferrin saturation(TS)<25%.Thirty-eight patients were randomized 1:1 to phlebotomy(n=21)or lifestyle changes alone(n=17).The main outcome of the study was improvement in liver damage according to the NAFLD activity score at 2 years,secondary outcomes were improvements in liver enzymes[alanine aminotransferases(ALT),aspartate aminotransferase(AST),and gamma-glutamyl-transferases(GGT)].RESULTS:Phlebotomy was associated with normalization of iron parameters without adverse events.In the21 patients compliant to the study protocol,the rate of histological improvement was higher in iron depleted vs control subjects(8/12,67%vs 2/9,22%,P=0.039).There was a better improvement in steatosis grade in iron depleted vs control patients(P=0.02).In patients followed-up at two years(n=35),ALT,AST,and GGT levels were lower in iron-depleted than in control patients(P<0.05).The prevalence of subjects with improvement in histological damage or,in the absence of liver biopsy,ALT decrease≥20%(associated with histological improvement in biopsied patients)was higher in the phlebotomy than in the control arm(P=0.022).The effect of iron depletion on liver damage improvement as assessed by histology or ALT decrease≥20%was independent of baseline AST/ALT ratio and insulin resistance(P=0.0001).CONCLUSION:Iron depletion by phlebotomy is likely associated with a higher rate of improvement of histological liver damage than lifestyle changes alone in patients with NAFLD and hyperferritinemia,and with amelioration of liver enzymes. | Luca Valenti Anna Ludovica Fracanzani Paola Dongiovanni Serena Rovida Raffaela Rametta Erika Fatta Edoardo Alessandro Pulixi Marco Maggioni Silvia Fargion | 2014 | World Journal of Gastroenterology2014，20，11： | 8 |
| 2 | Butyrates, as a single drug, induce histone acetylation and granuloeytic maturation: possible selectivity on core binding factor-acute myeloid leukemia Blasts显示文摘 | Gozzini A Rovida E Sbarba P D | 2003 | Cancer Res2003，63，9： | 1 |
| 3 | Butyrates,as a single drug,induce histone acetylation and granulocytic maturation:possible selectivity on core binding factor-Acute myeloid leukemia blasts 显示文摘 | Gozzini A Rovida E Sbarba P D | 2003 | Cancer Res2003，63，24： | 1 |
| 4 | Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legis- lation requirements for chemicals-A report by the transatlantic think tank for toxicology (t(4)) 显示文摘 | Rovida C Hartung T | 2009 | ALTEX2009，26，3： | 1 |
| 5 | Chemical regulators have over- reached 显示文摘 | Hartung T Rovida C | 2009 | Nature2009，460，7259： | 1 |
| 6 | Changing cir- culation rate of human metapneumovirus strains and types among hospitalized pediatric patients during three consecutive winter-spring seasons显示文摘 | Gerna G Campanini G Rovida F etal | 2005 | Arch Vir- ol2005，150，11： | 1 |
| 7 | Upper abdominal surgery:dose a lung function test exist to pridict early severe post operative respiratory complications显示文摘 | Barisione G Rovida S Gazzaninga GM | 1997 | Eur Respir J1997，10，： | 1 |
| 8 | Genetic variability of human eoronavirus OC43-, 229E-, and NL63-1ike strains and their association with lower respiratory tract infections of hospitalized infants and immunocompromised patients显示文摘 | Gerna G Campanini G Rovida F | 2006 | J Med Virol2006，78，7： | 1 |
| 9 | Monoclonal antibodies versus reverse transcription-PCR for detection of respiratory viruses in a patient population with respiratory tract infections admitted to hospital显示文摘 | Rovida F Percivalle E Zavattoni M | 2005 | J Med Virol2005，75，2： | 1 |
| 10 | Butyrates,as a single drug,induce histone acetylation and granulocytic maturation:Possible selectivity on core binding factor-acute myeloid leukemia blasts显示文摘 | Gozzini A Rovida E Dello Sbarba P | 2003 | Cancer Res2003，63，24： | 1 |
| 11 | Is intensive follow- up really able to improve prognosis of patients with local recurrence after curative surgery for rectal cancer ?显示文摘 | Seceo GB Fardelli R Rovida S | 2000 | Ann Surg Oncol2000，7，1： | 1 |
| 12 | Selective antileukaemic activity of low-dose histone deacetylase inhibitor ITF2357 on AML1/ETO-positive cells显示文摘 | Barbetti V Gozzini A Rovida E | 2008 | Oncogene2008，27，23： | 1 |
| 13 | Butyrates, as a single drug, induce histone acetylation and granulocytic maturation: possible selectivity on core binding factor-acute myeloid leukemia blasts 显示文摘 | GOZZINI A ROVIDA E DELLO SBARBA P | 2003 | Cancer Res2003，63，： | 1 |
| 14 | Upper abdominal surgery:does a lung function test exist to predict early severe postoperative respiratory complications? 显示文摘 | Barisione G Rovida S Gazzaniga GM | 1997 | Eur Respir J1997，10，6： | 1 |
| 15 | Upper abdominal surgery:does a lurg function test esist to predict early severe postoperative respiratory complicatoas? 显示文摘 | Barisione G Rovida S Gazzariga GM | 1997 | Eur Respir J1997，10，6： | 1 |
| 16 | Persistent human cosa- virus infection in lung transplant recipient, Italy显示文摘 | Campanini G Rovida F Meloni F | 2013 | Emerg In- fect Dis2013，19，10： | 1 |
| 17 | Is Intensive Follow-Up Really Able to Improve Prognosis of Patients With Local Recurrence After Curative Surgery for Rectal Cancer?显示文摘 | Giovanni B. Secco MD Roberto Fardelli MD Salvatore Rovida MD Daniela Gianquinto MD Eleonora Baldi MD Pierfrancesco Bonfante MD Lorenzo Derchi MD Romano Ferraris MD | 2000 | Annals of Surgical Oncology2000，，1： | 1 |
| 18 | Detection and pathogenicity of human metapneumovirus respiratory infection in pediatric Italian patients during a winter-spring season显示文摘 | Percivalle E Rovida F | 2006 | J Clin Virol2006，35，1： | 1 |
| 19 | Self-perception and oral health in pregnant adolescents显示文摘 | Rovida TA Moimaz SA Lima DP | 2014 | Oral Health Dent Manag2014，13，3： | 1 |
| 20 | Clinical severity and molecular typing of human rhinovirus C strains during a fall outbreak affecting hospitalized patients显示文摘 | Piralla A Rovida F Campanini G | 2004 | J Clin Virol2004，45，4： | 1 |
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