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| 1 | Electrospun poly(vinylidene fluoride-trifluoroethylene)/ zinc oxide nanocomposite tissue engineering scaffolds with enhanced cell adhesion and blood vessel formation显示文摘响应机械紧张产生电的信号的压电的材料能在设计刺激房间增长的织物被使用。Poly (vinylidene fluoride-trifluoroethylene )(P (VDF-TrFE )) ,压电的聚合物,广泛地在 biomaterial 应用被使用。我们假设了进 P (VDF-TrFE ) 矩阵的 nanoparticles 能支持的锌氧化物(ZnO ) 的那加入房间的粘附,移植,和增长,以及血容器形成(angiogenesis ) 。在这研究,我们制作了并且包括地描绘了新奇 electrospun P (VDF-TrFE )/ZnO nanocomposite 织物设计支架。我们由扫描电子显微镜学分析了聚合矩阵的词法特征,并且利用了红外线的光谱学, X 光检查衍射,和检验的微分扫描热量测定由于 nanoparticles 的增加在共聚物的水晶的阶段改变的 Fourier 变换。我们不检测了,显示 P (VDF-TrFE )/ZnO nanocomposite 脚手架对设计应用的织物合适或关于在 vitro, biocompatibility,和 cytotoxicity 的血相容性的 biomaterials 的最小的不利效果。有趣地,人的间充质的干细胞(hMSCs ) 和在 nanocomposite 脚手架上有教养的人的脐的静脉 endothelial 房间与在织物文化盘子或整洁的 P (VDF-TrFE ) 上有教养的房间相比展出了更高的房间生存能力,粘附,和增长脚手架。植入进老鼠与或没有 hMSCs 的 Nanocomposite 脚手架没得到免疫学的回答,由宏观的分析和组织学估计了。重要地, nanocomposite 脚手架支持了 angiogenesis,它在脚手架被增加与 hMSCs 预先播种。总的来说,我们的结果在织物工程为使用加亮这些新奇 P (VDF-TrFE )/ZnO nanocomposites 的潜力,由于他们支持房间粘附和 angiogenesis 的 biocompatibility 和能力。 | Robin Augustine Pan Dan Alejandro Sosnik Nandakumar Kalarikkal Nguyen Tran Brice Vincent Sabu Thomas Patrick Menu Didier Rouxel | 2017 | Nano Research2017，10，10： | 8 |
| 2 | Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation显示文摘The cysteine protease caspase-1(Casp-1)contributes to innate immunity through the assembly of NLRP3,NLRC4,AIM2,and NLRP6 inflammasomes.Here we ask whether caspase-1 activation plays a regulatory role in house dust mite(HDM)-induced experimental allergic airway inflammation.We report enhanced airway inflammation in caspase-1-deficient mice exposed toHDMwith a marked eosinophil recruitment,increased expression of IL-4,IL-5,IL-13,aswell as full-length and bioactive IL-33.Furthermore,mice deficient for NLRP3 failed to control eosinophil influx in the airways and displayed augmented Th2 cytokine and chemokine levels,suggesting that the NLPR3 inflammasome complex controls HDM-induced inflammation.IL-33 neutralization by administration of soluble ST2 receptor inhibited the enhanced allergic inflammation,while administration of recombinant IL-33 during challenge phase enhanced allergic inflammation in caspase-1-deficient mice.Therefore,we show that caspase-1,NLRP3,and ASC,but not NLRC4,contribute to the upregulation of allergic lung inflammation.Moreover,we cannot exclude an effect of caspase-11,because caspase-1-deficient mice are deficient for both caspases.Mechanistically,absence of caspase-1 is associated with increased expression of IL-33,uric acid,and spleen tyrosine kinase(Syk)production.This study highlights acritical role of caspase-1 activation andNLPR3/ASCinflammasomecomplex in the down-modulation of IL-33 in vivo and in vitro,thereby regulating Th2 response in HDM-induced allergic lung inflammation. | Fahima Madouri Noelline Guillou Louis Fauconnier Tiffany Marchiol Nathalie Rouxel Pauline Chenuet Aurelie Ledru Lionel Apetoh Franc¸ois Ghiringhelli Mathias Chamaillard Song Guo Zheng Fabrice Trovero Valerie F.J.Quesniaux Bernhard Ryffel Dieudonnee Togbe | 2015 | Journal of Molecular Cell Biology2015，7，4： | 8 |
| 3 | Tape cast alumina zirconia laminates:processing and mechanical properties显示文摘 | Chartier T Rouxel T | | 0，，2： | 1 |
| 4 | Coloniza- tion of winter oilseed rape tissues by A/Tox + and B/ Tox0 Leptosphaeria maculans (phoma stem canker)in France and England 显示文摘 | West J S Balesdent M H T Rouxel J P | 2002 | Plant Pathology2002，，51： | 1 |
| 5 | Densification of win- dow glass under very high pressure and its relevance to Vick- ers indentation显示文摘 | JI H KERYVIN V ROUXEL T | 2006 | Seripta Mater2006，55，12： | 1 |
| 6 | Enhance- ment of neutral lipid productivity in the microalga lsochrysis affinis Galbana( T- Iso) by a mutation -selection procedure 显示文摘 | BOUGARAN G ROUXEL C DUBOIS N | 2012 | Biotechnol Bioeng2012，109，11： | 1 |
| 7 | Thermal desorption-gas chromatography-mass spectrometry-flame ionization detection-sniffer multi-coupling : A device for the determination of odorous volatile organic compounds in air显示文摘 | KARPE P KIRCHNER S ROUXEL P | 1995 | Journal of Chromatography A1995，708，1： | 1 |
| 8 | Yttrium oxynitride glasses:Properties and potential for crystallization to glass-ceramics显示文摘 | HAMPSHIRE S NESTOR E FLYNN R BESSON J L ROUXEL T LEMERCIER H GOURSAT P SEBAI M THOMPSON LIDDELL K | 1994 | Journal of the European Ceramic Society1994，14，3： | 1 |
| 9 | De- scaling ability of low-alloy steel wires depending on compo- sition and rolling process 显示文摘 | GENEVE D ROUXEL D PIGEAT P M CONFENTE | 2010 | Corros Sci2010，52，1： | 1 |
| 10 | Antimony Isotope Variations in Natural Systems and Implications for Their Use as Geochemical Tracers显示文摘 | Rouxel O Ludden J Fouquet Y | 2003 | Chemical Geology2003，200，1： | 1 |
| 11 | Minimally invasive ablation of a toxic thyroid nodule by high-intensity focused ultrasound显示文摘 | Esnault O Rouxel A Nestour E | 2010 | Am J Neuroradiol2010，31，10： | 1 |
| 12 | Iron formation:The sedimentary product of a complex interplay among mantle,tectonic,oceanic,and biospheric processes显示文摘 | Bekker A Slack J F Planavsky N Krapez B Hofmann A Konhauser K O and Rouxel O J | | 0，，03： | 1 |
| 13 | Germanium isotopic systematics in Ge-rich coal from the Lincang Ge deposit, Yunnan, Southwestern China显示文摘 | Hua-Wen Qi Olivier Rouxel Rui-Zhong Hu Xian-Wu Bi Han-Jie Wen | 2011 | Chemical Geology2011，，3： | 1 |
| 14 | Metal stable isotopes in Paleoceanography显示文摘 | Anbar A D Rouxel O | 2006 | Ann Rev Earth Planet Sci2006，35，： | 1 |
| 15 | Subsurface processes at the Lucky Strike hydrothermal field, Mid-Atlantic Ridge: Evidence from sulfur, selenium, and iron isotopes显示文摘 | Rouxel O Fouquet Y Ludden J N | 2004 | Geochimica et Cosmochimica Aeta2004，68，： | 1 |
| 16 | Poisson's ratio and modern materials显示文摘 | Greaves G Lakes R Rouxel T | 2011 | Nat Mater2011，，10： | 1 |
| 17 | Prognostic factors associated with the survival of patients developing loco-regional recurrences of differentiated thyroid carcinomas 显示文摘 | Rouxel A Hejblum G Bernier MO | 2004 | J Clin Endocrinol Metab2004，89，11： | 1 |
| 18 | Mass spectrometry and natural variations of iron isotopes显示文摘 | Dauphas N Rouxel O | 2006 | Mass Spectrom Rev2006，25，： | 1 |
| 19 | Dental caries, sugars and food policy显示文摘 | Watt RG Rouxel PL | 2012 | Arch Dis Child2012，97，9： | 1 |
| 20 | Copper isotope system- atics of the Lucky Strike, Rainbow, and Logatchev sea-floor hydrothermal fields on the Mid-Atlantic Ridge显示文摘 | Rouxel O Fouquet Y Ludden J N | 2004 | Economic Geology2004，99，3： | 1 |
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