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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012,18,26: | 6 |
| 2 | Perinatal hypoxia-ischemia induces apoptotic and excitotoxic death of periventricular white matter oligodendrocyte progenitors显示文摘 | Ness J K Romanko M J Rothstein R P | 2001 | Dev Neurosci2001,23,3: | 1 |
| 3 | Interannual and decadal variability of the subsurface thermal structure in the Pacific Ocean: 1961-1990 显示文摘 | ZHANG R H ROTHSTEIN L M BASALACCHI A J | 1999 | Climate Dynamic1999,15,: | 1 |
| 4 | Genetic regulation by NLA and microRNA827for maintaining nitratedependent phosphate homeostasis in Arabidopsis显示文摘 | Kant S Peng M Rothstein S J | 2011 | Plos Genetics2011,7,3: | 1 |
| 5 | Pathologic features of Hashimoto's-associated papillary thyroid carcinomas显示文摘 | Di Pasquale M Rothstein JL Palazzo JP | 2001 | Hum Pathol2001,32,1: | 1 |
| 6 | An airline overbooking model显示文摘 | ROTHSTEIN M | 1971 | Transportation Science1971,5,: | 1 |
| 7 | Hotel overbooking as a markovian sequential decision process显示文摘 | ROTHSTEIN M | 1974 | Decision Science1974,,5: | 1 |
| 8 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘 | Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R | 1996 | Plant Cell1996,8,: | 1 |
| 9 | Pathologic features of Hashimoto's associated papillary thyroid carcinomas显示文摘 | Pasquale M Rothstein JL Palazzi JP | 2001 | Hum Pathol2001,32,1: | 1 |
| 10 | Biological functions of asparagine synthetase in plants显示文摘 | Gauqchon L Reisdorf-Cren M Rothstein S.J | | 0,,03: | 1 |
| 11 | Effects of nitrogen form on nutrient uptake and physiology of Fraser fir (Abies fraseri) 显示文摘 | Rothstein D E Cregg B M | 2005 | Forest ecology and management2005,219,1: | 1 |
| 12 | The S locus glycoprotein and the S receptor kinase are sufficient for self-pollen rejection in Brassica 显示文摘 | Cui Y Bi Y M Brugiere N Amoldo M and Rothstein S J | 2000 | Proceedings of the National Academy of Science of the USA2000,97,: | 1 |
| 13 | Hotel overbooking as a Markovian sequential decision process显示文摘 | | 1974 | Decision Science1974,5,: | 1 |
| 14 | OR and the Airline Overbooking Problem 显示文摘 | Rothstein M | 1985 | Operations Research1985,33,: | 1 |
| 15 | Intravenoos erythropoietin(rHuEPO) administration increases plasma endothelin and blood pressure in hemodialysis patients显示文摘 | Obialo CI Rothstein M | 1993 | Am J Hypertens1993,6,2: | 1 |
| 16 | Knockout of glutamate transporters reveals a major role for astroglial transportion in excitoxicity and clearance of glutamate 显示文摘 | Rothstein JD Dykes - Hoberg M Pardo CA | 2002 | Brain Res Mol Brain Res2002,104,2: | 1 |
| 17 | Intravenous erythropoietin (rHuEPO) administration increases plasma endothelin and blood pressure in hemodialysis patients 显示文摘 | Carlini R Obialo CI Rothstein M | 1993 | Arn J Hypertens1993,6,: | 1 |
| 18 | Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity 显示文摘 | Rothstein JD Jin L Dykes-Hoberg M Kuncl RW | 1993 | Proc Natl Acad Sci USA1993,90,14: | 1 |
| 19 | Knockout of glutamate transporters reveals a major role for astroglial transportin excitotoxicity and clearance of glutamate显示文摘 | Rothstein J D Dykes-Hoberg M Pardo C A | 1996 | Neuron1996,16,3: | 1 |
| 20 | Effects of nitrogen form on nutrient uptake and physiology of Fraser fir (Abies fraseri ) 显示文摘 | ROTHSTEIN D E CREGG B M | 2005 | Forest Ecology and Management2005,219,: | 1 |