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| 1 | Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice. | Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir | 2018 | World Journal of Gastroenterology2018，24，45： | 9 |
| 2 | Alternatively spliced lysyloxidas-like 4 isoforms have a pro metastatic role in cancer显示文摘 | Shulamit S Golan gerstl R Rotem K | 2013 | ClinExp Metastasis2013，30，1： | 1 |
| 3 | Improved antimicrobial peptides based on acyl-lysine oligomers显示文摘 | Radzishevsky IS Rotem S Bourdetsky D | 2007 | Nature Biotechnology2007，25，6： | 1 |
| 4 | The structure and interactions of the proline - rich domain of ASPP2 显示文摘 | ROTEM S KATZ C BENYAMINI H | 2008 | J Biol Chem2008，283，18： | 1 |
| 5 | Consequences of N-acylation on structure and membrane binding properties of dermaseptin derivative K4-S4-(1-13)显示文摘 | Shalev D E Rotem S Fish A | 2006 | J Biol Chem2006，281，14： | 1 |
| 6 | An asynchronous instruction length decoder显示文摘 | Stevens K S Rotem S Ginosar R | 2001 | IEEE Journal of Solid-State Circuits2001，36，： | 1 |
| 7 | Antimicrobial peptide mimics for improved therapeutic properties 显示文摘 | ROTEM S MOR A | 2009 | Biochimica et Biophysica Acta2009，1788，： | 1 |
| 8 | DNA - Templated Carbon Nanotube Field - Effect Transistor显示文摘 | Rotem S Berman Evgeny Buchstab etal | 2003 | Science2003，302，： | 1 |
| 9 | In vitro monomer swapping in Cmr, a multidrug transporter from Escherichia coli, reveals that the oligomer is the functional unit 显示文摘 | Rotem D Sal - man N Schuldine S | 2001 | Biochem2001，276，48： | 1 |
| 10 | Molecular basis of the interaction between the antiapoptotic Bcl-2family proteins and the proapoptotic protein ASPP2显示文摘 | Katz C Benyamini H Rotem S | 2008 | Proc Natl Acad Sci USA2008，105，12： | 1 |
| 11 | Antibacterial 1 properties of dermaseptinS4 derivatives under extreme incubation conditions显示文摘 | Rydlo T Rotem S Mor A | 2006 | AntimicrobAgents Chemother2006，50，2： | 1 |
| 12 | Nursing leaders of tomorrow: A peer selection process 显示文摘 | Picker - Rotem O Schneider A Wasserzug S | 2008 | Nurse Manage2008，16，8： | 1 |
| 13 | Antimicrobial peptide mimics for improved therapeutic properties 显示文摘 | ROTEM S MOR A | 2009 | Biochimica et Biophysica Acta2009，1788，： | 1 |
| 14 | In vitro monomer swapping in EmrE,a multidrug transporter from Escherichia coli,reveals that the oligomer is the functional unit显示文摘 | Rotem D Sal-man N Schuldine S | 2001 | Biochemistry2001，276，48： | 1 |
| 15 | Regional - Dependent Intes- tinal Permeability and BCS Classification: Elucidation of pH - Related Complexity in Rats Using Pseudoephedrine 显示文摘 | MORAN F ROTEM S ARIK D | 2013 | The AAPS Journal2013，15，2： | 1 |
| 16 | An asynchronous instruction length decoder显示文摘 | STEVENS K ROTEM S GINOSAR R | 2001 | IEEE Solid State Circuits2001，36，2： | 1 |
| 17 | Antimicrobial peptide mimics for improved therapeutic properties显示文摘 | Rotem S Mor A | | 0，，： | 1 |
| 18 | Life-threatening torsade de pointes arrhythmia associated with head injury显示文摘 | Constantini S Shir Y | 1998 | Neurosurgery1998，23，1： | 1 |
| 19 | Im- proved antimicrobial peptides based on acyl-lysine oligomers 显示文摘 | RADZISHEVSKY IS ROTEM S BOURDETSKY D | 2007 | Nat Biotechnol2007，25，6： | 1 |
| 20 | Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic显示文摘Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.Methods We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke centres.Patients with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,codes.The 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May 2020.The prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative drop.Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this tertile.Interpretation There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic.These findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction. | Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sugimura Masaaki Uno Yohei Takenobu Yuji Matsumaru Satoshi Yamada Ryuhei Kono Takuya Kanamaru Masafumi Morimoto Junichi Iida Vasu Saini Dileep Yavagal Saif Bushnaq Wenguo Huang Italo Linfante Jawad Kirmani David S Liebeskind Viktor Szeder Ruchir Shah Thomas G Devlin Lee Birnbaum Jun Luo Anchalee Churojana Hesham E Masoud Carlos Ynigo Lopez Brendan Steinfort Alice Ma Ameer E Hassan Amal Al Hashmi Mollie McDermott Maxim Mokin Alex Chebl Odysseas Kargiotis Georgios Tsivgoulis Jane G Morris Clifford J Eskey Jesse Thon Leticia Rebello Dorothea Altschul Oriana Cornett Varsha Singh Jeyaraj Pandian Anirudh Kulkarni Pablo M Lavados Veronica V Olavarria Kenichi Todo Yuki Yamamoto Gisele Sampaio Silva Serdar Geyik Jasmine Johann Sumeet Multani Artem Kaliaev Kazutaka Sonoda Hiroyuki Hashimoto Adel Alhazzani David Y Chung Stephan A Mayer Johanna T Fifi Michael D Hill Hao Zhang Zhengzhou Yuan Xianjin Shang Alicia C Castonguay Rishi Gupta Tudor G Jovin Jean Raymond Osama O Zaidat Raul G Nogueira SVIN COVID-19 Registry,the Middle East North Africa Stroke and Interventional Neurotherapies Organization(MENA-SINO),Japanese Society of Vascular and Interventional Neurology Society(JVIN) | 2021 | Stroke & Vascular Neurology2021，6，4： | 0 |
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