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| 1 | Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet显示文摘AIM To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS Sprague-Dawley rats were fed with 8% Na Cl highsalt(HS) or 0.4% Na Cl(normal-salt,NS) diet for 3 wk,with or without tempol(T)(1 mmol/L,administered in drinking water). Mean arterial pressure(MAP),glomerularfiltration rate(GFR),and urinary sodium excretion(UVNa) were measured. We evaluated angiotensin Ⅱ(Ang Ⅱ),angiotensin 1-7(Ang 1-7),angiotensin converting enzyme 2(ACE2),mas receptor(Mas R),angiotensin type 1 receptor(AT1R) and angiotensin type 2 receptor(AT2R) in renal tissues by immunohistochemistry.RESULTS The intake of high sodium produced a slight but significant increase in MAP and differentially regulated components of the renal renin-angiotensin system(RAS). This included an increase in Ang Ⅱ and AT1 R,and decrease in ACE-2 staining intensity using immunohistochemistry. Antioxidant supplementation with tempol increased natriuresis and GFR,prevented changes in blood pressure and reversed the imbalance of renal RAS components. This includes a decrease in Ang Ⅱ and AT1 R,as increase in AT2,ACE2,Ang(1-7) and Mas R staining intensity using immunohistochemistry. In addition,the natriuretic effects of tempol were observed in NS-T group,which showed an increased staining intensity of AT2,ACE2,Ang(1-7) and Mas R.CONCLUSION These findings suggest that a high salt diet leads to changes in the homeostasis and balance between opposing components of the renal RAS in hypertension to favour an increase in Ang Ⅱ. Chronic antioxidant supplementation can modulate the balance between the natriuretic and antinatriuretic components of the renal RAS. | Gabriel Cao Silvana Lorena Della Penna Nicolas Martín Kouyoumdzian Marcelo Roberto Choi Susana Gorzalczany Belisario Enrique Fernández Jorge Eduardo Toblli María Inés Roson | 2017 | World Journal of Nephrology2017，6，1： | 4 |
| 2 | general equilibrium analysis of climate change impacts on tourism显示文摘 | Berrittella M Bigano A Roson R A | 2006 | Tourism Management2006，27，5： | 1 |
| 3 | Novel regulators of bone formation:Molecular clones and activities显示文摘 | Wozney J M Roson V Celeste A J | 1988 | Science1988，242，： | 1 |
| 4 | Leaf emer- gence, tiller growth, and apical development of nitrogen-defi- cient spring wheat显示文摘 | LONGNECKER N KIRBY E J M ROSON A | 1993 | Crop Science1993，33，： | 1 |
| 5 | A General Equilibrium Analysis of Climate Change Impacts on Tourism显示文摘 | BERRITTELLA M B A ROSON R | 2006 | Tourism Management2006，27，5： | 1 |
| 6 | A general equilibrium analysis of climate change impacts on tourism 显示文摘 | Berrittella M Bigano A Roson R Richard S J | 2006 | Tourism Management2006，27，5： | 1 |
| 7 | A general equilibrium analysis of climate change impacts on tourism 显示文摘 | Berrittella M Bigano A Roson R | 2006 | Tourism Management2006，27，5： | 1 |
| 8 | Community-acqnired pneumonia in very elderly patients:causative organisms,clinical characteristics,and outcomes显示文摘 | Fern a ndez-Sab e N Carratala J Roson B | 2003 | Medicine2003，82，： | 1 |
| 9 | An extension of the Burrows-Wheeler Transform显示文摘 | MANTACI S RESTIVO A ROSONE G | 2007 | Theoretical Computer Science2007，387，3： | 1 |
| 10 | Aspiration diseases:findings,pitfalls,and differential diagnosis显示文摘 | Gimenez A Roson N | 2000 | Radiographics2000，20，： | 1 |
| 11 | Aspiration diseases: find- ings, pitfalls, and differential diagnosis 显示文摘 | Franquet T Gimenez A Roson N | 2000 | RadioGraphics2000，20，： | 1 |
| 12 | HIV regulatory protein:Potential targets for therapeutic intervention 显示文摘 | Roson C A | 1992 | AIDS Res Hum Retro1992，8，： | 1 |
| 13 | Structural and functional characterization of human immunodeficiency virus Tat protein 显示文摘 | Roson C A | 1989 | J Virol1989，63，： | 1 |
| 14 | Lymphomatoid contact dermatitis induced by gold earrings 显示文摘 | Conde-Taboada A Roson E Femandez-Redondo V | 2007 | Contact Dermatitis2007，56，3： | 1 |
| 15 | A general equilibrium analysis of climate change impacts on tourism显示文摘 | BERRITTELLA M BIGANO A ROSON R | 2006 | Tourism Management2006，27，5： | 1 |
| 16 | Eosinophilic pannic- ulitis after subcutaneous adminstration of sodium heparin 显示文摘 | Battlla A Roson E Posada C | 2013 | Indian J Dermatol Venereol Leprot2013，79，6： | 1 |
| 17 | A general equilibrium analysis of climate change impacts on tourism显示文摘 | Berrittella M Bigano A Roson R | 2006 | Tourism Management2006，，27： | 1 |
| 18 | Aspiration diseases: findings, pitfalls, and differential diagnosis 显示文摘 | Franquet T Gimenez A Roson N | 2000 | Radiographics2000，20，3： | 1 |
| 19 | A general equilibri- um analysis of climate change impacts on tourism 显示文摘 | Berrittella Mafia Bigano A Roson R | 2006 | Tourism Management2006，27，5： | 1 |
| 20 | A general equilibrium analysis of climate change impacts on tourism显示文摘 | Berrittella M Bignao A Roson R | | 0，，05： | 1 |
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