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| 1 | Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review显示文摘BACKGROUND Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies.Different signaling pathways that participate in the progression of these tumors have been identified.B-raf proto-oncogene serine/threonine kinase(BRAF)is a protein involved in the behavior of ameloblastomas,and it is related to many cell mechanisms.BRAF gene mutations have been identified in ameloblastomas,of which the BRAF V600E(valine substituted by glutamic acid at amino acid 600)mutation has been the most common and can be present concomitantly with other mutations that may be involved in its behavior.Targeted therapies have been used as an alternative in the case of resistance or contraindications to conventional treatments.AIM To document the presence of BRAF V600E and additional mutations,their behavior,and targeted therapies in these tumors.METHODS An electronic literature search was conducted according to PRISMA guidelines in PubMed/MEDLINE,Cochrane,EMBASE,and SpringerLink using the terms“ameloblastomas”,“BRAF V600E”,“additional mutations”,and“targeted therapies”.Ameloblastomas were classified according to WHO guidelines.Inclusion criteria were articles in English,published not more than 10 years ago,and studies with laboratory works related to BRAF V600E.Articles were evaluated by two independent reviewers and retrieved for full-text evaluation.The EBLIP Critical Appraisal Checklist was used to evaluate the quality of the eligible studies.Descriptive statistical analysis was performed.RESULTS Two independent reviewers,with a substantial concordance indicated by a kappa coefficient of k=0.76,evaluated a total of 19 articles that were included in this study.The analysis registered 521 conventional ameloblastomas(AM),81 unicystic ameloblastomas(UA),13 ameloblastic carcinomas(AC),three metastatic ameloblastomas(MA),and six peripheral ameloblastomas(PA),of which the histopathological type,anatomic location,laboratory tests,expression of BRAF mutation,and additional mutations were registered.The BRAF V600E mutation was found in 297 AM(57%),63 UA(77.7%),3 AC(23%),1 MA(50%),and 5 PA(83.3%).Follicular type predominated with a total of 116 cases(40%),followed by plexiform type with 63 cases(22.1%).Furthermore,both types presented additional mutations,in which alterations in JAK3 P132T,SMARCB1,PIK3CA,CTNNB1,SMO,and BRAF G606E genes were found.Four case reports were found with targeted therapy to BRAF V600E.CONCLUSION The identification of BRAF V600E and additional mutations as an aid in targeted therapies has been a breakthrough in alternative treatments of ameloblastomas where surgical treatments are contraindicated. | Rogelio González-González Sandra López-Verdín Jesús Lavalle-Carrasco Nelly Molina-Frechero Mario Isiordia-Espinoza Ramón G Carreón-Burciaga Ronell Bologna-Molina | 2020 | World Journal of Clinical Oncology2020，11，1： | 6 |
| 2 | 分段进水多级A/O工艺研究进展显示文摘简述了活性污泥法分段进水多级A/O工艺(SAOASP)的基本原理与特点,详细探讨了9种参数对SAOASP脱氮性能的影响,系统总结了SAOASP的研究现状、应用情况以及SAOASP改良工艺,包括SAOASP-UCT、SAOASP-SBR、SAOASP-CAST和SAOASP-MBR。基于活性污泥法存在的问题,综述了基于不同类型生物膜法的分段进水多级A/O工艺(SAOBP),包括MBBR、BCO、RBC、BAF和FB。最后对该工艺存在的问题和发展方向进行了展望。 | 侯子泷 周鑫 Koubode Rudy Alain Ronel 张琦 孙海龙 吕琳 | 2020 | 工业水处理2020，40，6： | 4 |
| 3 | Ovarian hyperstimulationsyndrome:an update review 显示文摘 | Golan A Ronel R Herman A | 1989 | ObstetGynecol Surv1989，44，6： | 1 |
| 4 | Mapping knowledge flows in virtual teams with SNA 显示文摘 | FRANK D BEHREND RONEL E | 2009 | Journal of Knowledge Manage- ment2009，13，4： | 1 |
| 5 | Trends, risk factors and pregnancy outcome in women with uterine rupture 显示文摘 | Ronel D Wiznitzer A Sergienko R | 2012 | Arch Gynecol Obstet2012，285，2： | 1 |
| 6 | Ovarian hypestimulation syndrome:an update view显示文摘 | Golan A Ronel R Heman A | 1989 | Obstet Cynecol Surv1989，44，6： | 1 |
| 7 | Elective groin irradiation is not indicated for patients with adenocarcinoma of the rectum extending to the anal canal显示文摘 | Noah Taylor Christopher Crane John Skibber Barry Feig Lee Ellis Jean-Nicholas Vauthey Stanley Hamilton Karen Cleary Ronelle Dubrow Thomas Brown Robert Wolff Paulo Hoff Nicholas Sanfilippo Nora Janjan | 2001 | International Journal of Radiation Oncology Biology Physics2001，，3： | 1 |
| 8 | Ovarian hyperstimulation syndrome: an update review显示文摘 | Golan A Ronel R Soffer Y | 1989 | Obstet Gynecol Survey1989，44，： | 1 |
| 9 | Ovarian hyperstimulation syndrome : an update review显示文摘 | Golan A Ronel R Herman A | 1989 | Obstet Gynecol Surv1989，44，6： | 1 |
| 10 | Ovarian Hyperstimulation Sydrome:an update review显示文摘 | Golan A Ronel R Herman A | 1989 | Obstet Gyneccl Surv1989，44，： | 1 |
| 11 | Henri Albert Hartmann: labor and disci- pline 显示文摘 | Ronel DN Hardy MA | 2002 | Curr Surg2002，59，1： | 1 |
| 12 | Ovarian hyper stimulation syndromej an update review显示文摘 | Golan A Ronel R Herman A et a1 | 1989 | Obstet Gynecol Surv1989，44，6： | 1 |
| 13 | Imaging in the diagnosis,staging,and follow-up of colorectal cancer显示文摘 | Revathy B Paul M Ronelle A | 2002 | AJR2002，179，： | 1 |
| 14 | Ovarian hyperstimulation syndromes: an update review显示文摘 | Golan A Ronel R Herman A | 1989 | Obstet Gynecol Surv1989，44，6： | 1 |
| 15 | Ovarian hyperstimulation syndrome:an update review显示文摘 | Golan A Ronel R Herman A | 1989 | Obstet Gynecol Surv1989，44，6： | 1 |
| 16 | Imaging in the diagnosis, staging and following-up of colorectal cancer 显示文摘 | Rvathy B Paul M Ronelle A et at | 2002 | Am J Roentgenol2002，179，1： | 1 |
| 17 | Trends,risk factors and pregnancy outcome in women with uterine rupture显示文摘 | Ronel D Wiznitzer A Sergienko R | 2012 | Arch Gynecol Obstet2012，285，： | 1 |
| 18 | Ovarian hyper stimulation syndrome: an update review 显示文摘 | Golan A Ronel R Herman A | 1989 | Obstet Gynecol Survey1989，44，6： | 1 |
| 19 | Ovarian hyperstimulation syndrome : an update review 显示文摘 | Golan A Ronel R Herman A | 1989 | Obstet Gyneed Survey1989，44，6： | 1 |
| 20 | Ovarian hyperstimu-lation syndrome: an update review 显示文摘 | Golan A Ronel R Herman A | 1989 | Obstet GynecolSurv1989，44，6： | 1 |
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