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| 1 | Non-invasive diagnosis of gastric mucosal atrophy in an asymptomatic population with high prevalence of gastric cancer显示文摘AIM: To validate a non-invasive method to detect gastric mucosal atrophy in a Chilean population with high prevalence of gastric cancer and a poor survival rate. METHODS: We first determined the optimal cut-off level of serum pepsinogen (PG)-1, PG-1/PG-2 ratio and 17-gastrin in 31 voluntary symptomatic patients (mean age: 66.1 years), of them 61% had histologically confirmed gastric atrophy. Then, in a population-based sample of 536 healthy individuals (209 residents in counties with higher relative risk and 327 residents in counties with lower relative risk for gastric cancer), we measured serum anti-H pylori antibodies, PG and 17-gastrin and estimated their risk of gastric cancer. RESULTS: We found that serum PG-1 < 61.5 μg/L, PG-1/PG-2 ratio < 2.2 and 17-gastrin > 13.3 pmol/L had a high specificity (91%-100%) and a fair sensitivity (56%-78%) to detect corpus-predominant atrophy. Based on low serum PG-1 and PG-1/PG-2 ratio together as diagnostic criteria, 12.5% of the asymptomatic subjects had corpus-predominant atrophy (0% of those under 25 years and 20.2% over 65 years old). The frequency of gastric atrophy was similar (12% vs 13%) but H pylori infection rate was slightly higher (77% vs 71%) in the high-risk compared to the low-risk counties. Based on their estimated gastric cancer risk, individuals were classified as: low-risk group (no H pylori infection and no atrophy; n = 115; 21.4%); moderate-risk group(H pylori infection but no atrophy; n = 354, 66.0%); and high-risk group (gastric atrophy, with or without H pylori infection; n = 67, 12.5%). The high-risk group was significantly older (mean age: 61.9 ± 13.3 years), more frequently men and less educated as compared with the low-risk group. CONCLUSION: We propose to concentrate on an upper gastrointestinal endoscopy for detection of early gastric cancer in the high-risk group. This intervention model could improve the poor prognosis of gastric cancer in Chile. | Antonio Rollan Catterina Ferreccio Alessandra Gederlini Carolina Serrano Javiera Torres Paul Harris | 2006 | World Journal of Gastroenterology2006，12，44： | 14 |
| 2 | Optimal length of triple therapy for H pylori eradication in a population with high prevalence of infection in Chile显示文摘AIM:To compare the efficacy of 7-d versus 14-d triple therapy for the treatment of H pylori infection in Chile,with a prevalence of 73% in general population. METHODS:H pylori-infected patients diagnosed by rapid urease test,with non-ulcer dyspepsia or peptic ulcer disease were randomized to receive omeprazole 20 mg bid,amoxicillin 1 g bid,and clarithromycin 500 mg bid for 7 (OAC7) or 14 (OAC14) d. Primary outcome was eradication rate 6 wk after the treatment. Subgroup analysis was carried out considering the eradication rate among patients with or without peptic ulcer disease and eradication rate among smokers or non-smokers. RESULTS:One hundred and thirty-one patients were randomized to OAC7 (n = 69) or OAC14 (n = 62). The overall eradication rate (intention-to-treat) was 78.3% in OAC7 and 85.5% in OAC14 groups,without a significant difference (P =0.37). No significant difference in the eradication rate was found among the patients with peptic ulcer disease (n = 31) between the OAC7 group (85.7%) and OAC14 group (87.5%). However,smokers had an obviously lower eradication rate compared to non-smokers,particularly in the OAC7 group (57.1% in smokers vs 83.6% in non-smokers; P = 0.06). Adverse effects rate were similar between both groups. CONCLUSION:Short-term efficacy of triple therapy with OAC for 7 d is comparable to 14 d in this high-prevalence population. Longer follow-up,and studies focused to some subgroups of patients (smokers and non-ulcerpatients) are necessary to support widespread use of 7-d instead of 10-14-d triple therapy in a developing country like Chile. | Arnoldo Riquelme Alejandro Soza Cesar Pedreros Andrea Bustamante Felipe Valenzuela Francisco Otarola Eduardo Abbott Marco Arellano Brenda Medina Alejandro Pattillo Douglas Greig Marco Arrese Antonio Rollan | 2007 | World Journal of Gastroenterology2007，13，21： | 3 |
| 3 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 4 | A detailed study of the activity and deactivation of zeolites in hybrid Co/Si02-zeolite Fischer-Tropsch catalysts 显示文摘 | Agustin Martinez Joan Rollan Maria A Arribas | 2007 | Journal of Catalysis2007，249，2： | 1 |
| 5 | Crisis sentinel indieators: Averting a potential meltdown in the Coral Triangle显示文摘 | Reniel Cabral Annabelle Cruz-Trinidad Rollan Geronimo et | 2013 | Marine Polie2013，，39： | 1 |
| 6 | C,Lonvaud-Funel,A,Histidine carboxy-lase of Leuconostoc oenos 9204:purification,kinetic proper-ties,cloning and nucleotide sequence of the hdc gene显示文摘 | Coton E Rollan G | 1998 | Journal of Applied Microbiology1998，84，： | 1 |
| 7 | Studies on the biosorption of uranium by a thermotolerant, ethanol-producing strain of Kluyveromyces marxianus显示文摘 | Bustard M Donnellan N Rollan A | 1997 | Bioprocess Engineering1997，17，1： | 1 |
| 8 | The long-term reinfection rate and the course of duodenal ulcer disease after eradication of Helicobacter pylori in a developing country 显示文摘 | ROLLAN A GIANCASPERO R FUSTER F | 2000 | Am J Gastroenterol2000，95，1： | 1 |
| 9 | Histidine carboxylase of Leuconostoc oenos 9204: purification, kinetic properties, cloning and nucleotide sequence of the hdc gene 显示文摘 | Coton E Rollan GC Lonvaud-Funel A | 1998 | J Appl Microbiol1998，84，2： | 1 |
| 10 | The long-term renfection rate and the couse of duodenal ulcer disease after eradication of Helicobacter pylori in a developing country显示文摘 | Rollan A Giancaspero R Fuster F | 2000 | Am J Gastroenterol2000，95，： | 1 |
| 11 | Serological response to He- licobacter pylori recombinant antigens in Chilean infected pa- tients with duodenal ulcer, non-ulcer dyspepsia and gastric cane er显示文摘 | Opazo P Muller I Rollan A | 1999 | APMIS1999，107，12： | 1 |
| 12 | The long-term reinfection rate and course of duodenal ulcer disease eradication of helicobacter pylori in a developing country显示文摘 | Rollan A Giancaspero R Fuster F | 2000 | Am J Gastroenterol2000，95，1： | 1 |
| 13 | Nanofibrous γ-Al2O3 as support for Co-based Fischer-Tropsch catalysts: Pondering the relevance of diffusional and dispersion effects On catalytic performance 显示文摘 | MARTUNEZ A PRIETO G ROLLAN J | 2009 | J Catal2009，263，2： | 1 |
| 14 | We just ask some questionsy'the process of antenatal psychosocial assessment by midwives显示文摘 | Rollans M Schmied V Kemp L | | 0，，： | 1 |
| 15 | The Effect of Pulse Voltage and Capacitance on Biosorption of Uranium by Biomass Derived from Whiskey Distillery Spent Wash显示文摘 | Bustard M Rollan A McHale A P | 1998 | Bioprocess Engineering1998，，18： | 1 |
| 16 | Value of contrast echocardiography for the diagnosis of hepatopulmonary syndrome显示文摘 | Rollan M J Mufioz AC P6rez T | 2007 | Eur J Echocardiogr2007，8，5： | 1 |
| 17 | Modeling the risk of collision with power lines in Bonelli's Eagle H ieraaetus fasciatus and its conservation implications 显示文摘 | ROLLAN k REAL J BOSCH R | 2010 | Bird Conservation International2010，20，： | 1 |
| 18 | Gastric cancer is related to early Helicobacter pylori infection in a high-prevalence country 显示文摘 | Ferreccio C Rollan A Harris PR et al | 2007 | Cancer Epidemiol Biomarkers Prey2007，16，4： | 1 |
| 19 | A detailed study of the activity and deactivation of zeolites in hybrid Co/SiO2-zeolite Fische-Tropsch catalysts显示文摘 | MARTINEZ A ROLLAN J ARRIBAS M A | 2007 | Journal of Catalysis2007，249，2： | 1 |
| 20 | The long-termreinfection rate and course of duodenal ulcer disease eradication of Helicobacter pylori in a developing country显示文摘 | Rollan A Giancaspro R Fuster F | 2000 | Am J Gastroentero12000，95，1： | 1 |
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